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Raynaud's Syndrome - Biotech, Pharma and Life Science Channel

02:05 EDT 24th October 2017 | BioPortfolio

PubMed Articles [4820 Associated PubMed Articles listed on BioPortfolio]

Genetic addiction risk score (GARS) ™, a predictor of vulnerability to opioid dependence.

The interaction of neurotransmitters and genes that control the release of dopamine is the Brain Reward Cascade (BRC). Variations within the BRC, whether genetic or epigenetic, may predispose individu...

Modified low-density lipoproteins as biomarkers in diabetes and metabolic syndrome.

Cardiovascular disease of atherosclerotic origin is the main cause of death in diabetes mellitus and metabolic syndrome. One of the mechanisms involved in such increased risk is the high incidence of ...

Natural aging as as a sequential poly-systemic syndrome.

We review the progression of aging as a sequential development of multiple syndromes analogous to other diseases. This generalized approach may allow practicing physicians to consider the signs of agi...

Leader sequences of coronavirus are altered during infection.

The life cycle of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) involves a unique process called discontinuous transcription by which a set of 3' coterminal subgenomic mRNAs (sgmRNA) with i...

Hypertension and cardiometabolic disease.

Hypertension has  a central role in cardiometabolic disease and is usually associated with  metabolic disorders, such as insulin resistance, obesity, and dyslipidemia. Hyperinsulinemia may increase ...

Extracorporeal CO2 removal by hemodialysis: in vitro model and feasibility.

Critically ill patients with acute respiratory distress syndrome and acute exacerbations of chronic obstructive pulmonary disease often develop hypercapnia and require mechanical ventilation. Extracor...

Human perinatal immunity in physiological conditions and during infection.

The intrauterine environment was long considered sterile. However, several infectious threats are already present during fetal life. This review focuses on the postnatal immunological consequences of ...

Systematic review and meta-analysis of complications and mortality of veno-venous extracorporeal membrane oxygenation for refractory acute respiratory distress syndrome.

Veno-venous extracorporeal membrane oxygenation (ECMO) for refractory acute respiratory distress syndrome (ARDS) is a rapidly expanding technique. We performed a systematic review and meta-analysis of...

Degradation and inactivation of Shiga toxins by nitrogen gas plasma.

Shiga toxin (Stx)-producing Escherichia coli (STEC) leads to food poisoning by causing hemorrhagic colitis and hemolytic uremic syndrome. Some STEC produce Shiga toxin 1 (Stx1) and/or Shiga toxin 2 (S...

Can glypican-3 be a disease-specific biomarker?

Glypican-3 (GPC3) is a cell surface-bound proteoglycan which has been identified as a potential biomarker candidate in hepatocellular carcinoma, lung carcinoma, severe pneumonia, and acute respiratory...

News Articles [1151 Associated News Articles listed on BioPortfolio]

Global Blood Takes HOPE In Sickle Cell After Pulmonary Fibrosis Failure

GBT440 is not efficacious enough in studies of idiopathic pulmonary fibrosis, but the drug was well-tolerated at twice the exposure...   

Eisai Opts In On Biogen's High-Profile Aducanumab

Biogen secures stronger economics for the Phase III Alzheimer's disease drug in the US and Europe in the joint development/commercialization...  

GSK’s ‘bubble baby’ gene therapy passes NICE’s new stricter test

GlaxoSmithKline’s gene therapy Strimvelis for the treatment of the ultra-rare ‘bubble baby syndrome’ has been approved by NICE. The one-off therapy costs €594,000, equivalent to £505,000 or ...

NICE approves gene therapy for rare ‘bubble baby syndrome’

The UK medicines cost-effectiveness watchdog the National Institute for Health and Care Excellence (NICE)…

Pipeline Watch: Phase III Readouts For Cabozantinib, Topical Glycopyrronium

Pipeline Watch is a weekly snapshot of selected late-stage clinical trial events announced by pharmaceutical and biotech companies at medical...   

NICE nod for GSK’s ‘bubble baby syndrome’ gene therapy

The National Institute for Health and Care Excellence has published draft guidance recommending GlaxoSmithKline’s gene therapy Strimvelis as an option for treating an ultra-rare immune deficienc...

Herbals: Science Catching Up With Mother Nature

Since prehistoric times, herbal remedies have been touted as cures for a wide range of medical conditions, including colds, depression, memory loss, premenstrual syndrome, and hundreds of others...

Britain backs GSK's gene therapy for 'bubble boy' syndrome

(Reuters) - GlaxoSmithKline's gene therapy for the so-called "bubble boy" disease was approved by Britain's healthcare cost watchdog NICE, despite a price tag of almost 600,000 euros ($700,000).

GSK Bubble Baby Syndrome Gene Therapy Gets NICE Nod

The cost of Strimvelis is €594,000 but treatment is usually given once only and thought to be life-long. It is...    

Death of Woman's Dog Literally Broke Her Heart

What is broken heart syndrome, what are the signs and symptoms, and what can you do about it?

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Companies [63 Associated Companies listed on BioPortfolio]

Sancilio Pharmaceuticals Company, Inc.

Sancilio Pharmaceuticals Company, Inc. (SPCI) is a fully integrated, specialty pharmaceutical company focused on developing, manufacturing and commercializing pharmaceutical produ...

Agilis Biotherapeutics and GTRI

Agilis is advancing innovative gene therapies designed to provide long-term efficacy for patients with debilitating, often fatal, rare genetic diseases that affect the central ner...

PAVmed Inc.

PAVmed Inc. (Nasdaq: PAVM, PAVMW) is a highly differentiated, multi-product medical device company employing a unique business model designed to advance products from concept to c...

Agilis Biotherapeutics, Inc.

Agilis is advancing innovative gene therapies designed to provide long-term efficacy for patients with debilitating, often fatal, rare genetic diseases that affect the central ner...

Ironwood Pharmaceuticals, Inc. 

Ironwood Pharmaceuticals (NASDAQ:IRWD) is a commercial biotechnology company focused on creating medicines that make a difference for patients, building value for our fellow share...

Mati Therapeutics, Inc.

Mati is developing the Evolute® sustained ocular drug delivery platform, which Mati believes has the potential to treat a range of ocular indications. The platform utilizes a d...

MedAutonomic

MedAutonomic is a privately held medtech company dedicated to developing a bioelectric medicine to treat patients with functional diseases of the metabolic syndrome such as type-2...

Ironwood Pharmaceuticals, Inc. & Astellas Pharma Inc.

Ironwood Pharmaceuticals (NASDAQ: IRWD) is a commercial biotechnology company focused on creating medicines that make a difference for patients, building value for our fellow shar...

XenoPort

We are a biopharmaceutical company focused on developing a portfolio of internally discovered product candidates for the potential treatment of central nervous system (CNS) disorders. We also have a p...

Velicept Therapeutics, Inc.

Velicept Therapeutics, Inc. is a privately held, clinical development company focused on advancing best-in-class compounds with the potential to fill unmet medical needs. Its lead...

Clinical Trials [3298 Associated Clinical Trials listed on BioPortfolio]

Exercise for Subacromial Pain Syndrome

This study evaluates the effect of "heavy slow resistance" exercise in comparioson with conventional exercise. Half of participants will complete the heavy slow resistance exercise, the ot...

NoL Index Variations Before and After a Stellate Ganglion Block

To evaluate and compare the NoL index variations after a painful physiotherapy exercise in patients with upper limb CRPS, before and after a stellate ganglion block.

Melatonin Levels and the Relation to Obesity and the Metabolic Syndrome in Children and Adolescents

Background: Melatonin is a neurohormone that regulates the circadian rhythm by translating photoperiodic information from the eyes to the brain. Working hypothesis and aims: There is a po...

Pregnancy Related Inappropriate Sinus Tachycardia

A feasibility study into the exploration of possible mechanisms underlying inappropriate sinus tachycardia (IST) syndrome in pregnancy.

Expanded Access to Provide ARQ 092 for the Treatment of Overgrowth Diseases and/or Vascular Anomalies

ARQ 092 is being investigated for patients with overgrowth diseases and/or vascular anomalies with genetic alterations of the PI3K/AKT pathway and may be available for patients who are ine...

Posaconazole Prophylaxis During ATG Treatment for hMDS/AA Patients

To investigate the efficacy of posaconazole as prophylaxis antifungal agent in aplastic anemia / hypoplastic myelodysplastic syndrome (AA/hMDS) patients undergoing antithymocyte globulin (...

Berlin-Brandenburg Pregnancy Cohort

This study will investigate the interplay of different immune cells and placental cells as well as their potential for the development of pregnancy complications. In particular, the transl...

Investigating Burnout in Intensive Care in Middle Incoming Turkey

Turkey is a developing country and its intensive care infrastructure is worse than developed countries. The staff is very busy at work. Intensive care has become a new science. We wanted t...

The Role of Myristic Acid in Serum for Early Diagnosis of Sepsis and Comparison With Selected Biomarkers of Sepsis

The aim of the study is to measure serum levels of myristic acid in septic patients and to compare them with myristic acid serum levels in patients with Systemic Inflammatory Response Synd...

Airway Ultrasound Prediction and Correlation

This is a novel approach to assess the use of ultrasound to support the identification of obstructive sleep apnea syndrome (OSAS) on a screening questionnaire, and potentially to predict a...

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Medical and Biotech [MESH] Definitions

An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.

A mild form of LIMITED SCLERODERMA, a multi-system disorder. Its features include symptoms of CALCINOSIS; RAYNAUD DISEASE; ESOPHAGEAL MOTILITY DISORDERS; sclerodactyly, and TELANGIECTASIS. When the defect in esophageal function is not prominent, it is known as CRST syndrome.

A selective adrenergic alpha-1 antagonist used in the treatment of heart failure, hypertension, pheochromocytoma, Raynaud's syndrome, prostatic hypertrophy, and urinary retention.

A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.

A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a "speckled" epidermal nuclear staining pattern on direct immunofluorescence.

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