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Streptokinase Astra - Biotech, Pharma and Life Science Channel

00:00 EST 19th February 2019 | BioPortfolio

PubMed Articles [7 Associated PubMed Articles listed on BioPortfolio]

Increased Mast Cell Abundance in Adipose Tissue of Nascent Metabolic Syndrome: Relevance to the Pro-Inflammatory State and Increased Adipose Tissue Fibrosis.

Metabolic Syndrome (MetS) affects 35% of American adults > 40 years and portends an increased risk for both cardiovascular disease (ASCVD) and diabetes. The role of mast cells in the pro-inflammatory ...

CRISPR/Cas9-mediated gene editing in an exogenous transgene and an endogenous sex determination gene in the Caribbean fruit fly, Anastrepha suspensa.

CRISPR/Cas9-mediated gene-editing, using injected Cas9 protein, was achieved in the Caribbean fruit fly, Anastrepha suspensa, by initially targeting an exogenous transgene, polyubiquitin-regulated EGF...

Design of a DNA-programmed plasminogen activator.

Although the functional specificity and catalytic versatility of enzymes have been exploited in numerous settings, controlling the spatial and temporal activity of enzymes remains challenging. Here we...

Lipid modification of staphylokinase and its implications on stability and activity.

Thrombolytic agents are routinely used to dissolve blood clot by activating fibrinolytic system. Among different thrombolytic agents available, staphylokinase (SAK) is gaining much attention because o...

Rapid antibiotic susceptibility testing on blood cultures using MALDI-TOF MS.

Antibiotic resistance is a major public health problem requiring the early optimization of antibiotic prescriptions. Matrix-Assisted Laser Desorption Ionization-Time Of Flight Mass Spectrometry (MALDI...

Bufadienolides from Kalanchoe daigremontiana modulate the enzymatic activity of plasmin - In vitro and in silico analyses.

Plasmin (EC 3.4.21.7) is a key enzyme of the fibrinolytic system, responsible for the degradation of fibrin clot and maintaining blood fluidity. Hence, alterations of the fibrinolytic capacity of bloo...

Multiple-therapy-resistant major depressive disorder: a clinically important concept.

SummaryMany novel therapeutic options for depression exist that are either not mentioned in clinical guidelines or recommended only for use in highly specialist services. The challenge faced by clinic...

News Articles [29 Associated News Articles listed on BioPortfolio]

I’m guessing Astra hasn’t been up this much (8% currently) in a day since the original PACIFIC readout. About $7B in market value.

I’m guessing Astra hasn’t been up this much (8% currently) in a day since the original PACIFIC readout. About $7B in market value.

The only two large pharma companies with positive earnings results (at least judged by how stocks reacted) were Merck and Astra.

The only two large pharma companies with positive earnings results (at least judged by how stocks reacted) were Merck and Astra.

2) China is now 18% of revenue and growing. That’s incredible and Astra deserve credit for having done the best job of any multinational of focusing there. The Tagrisso launch will be a model for all companies in the region to learn from when launching

2) China is now 18% of revenue and growing. That’s incredible and Astra deserve credit for having done the best job of any multinational of focusing there. The Tagrisso launch will be a model fo...

Investors are cheering the Astra numbers but I’m a little more cautious given all the personnel changes and reorganizing happening there. It’s just as likely to cause distractions and slow them down as anything else.

Investors are cheering the Astra numbers but I’m a little more cautious given all the personnel changes and reorganizing happening there. It’s just as likely to cause distractions and slow...

AstraZeneca posts first rise in annual product sales for almost ten years

Patent expiries on key blockbusters such as Crestor and Seroquel have put a huge dent in sales over the past decade or so, but Astra returned to growth in 2018

Sobi tar klivet in bland större läkemedelsbolag

Sobi meddelade i mitten av november att man köper rättigheterna till ett läkemedel från Astra- Zeneca med den största marknadsandelen i USA.

Global Transvaginal Endoscopy Market Status and Outlook 20182025 [Report Updated: 15082018] Prices from USD $4000

Report SnapshotKey Content of Chapters Including and can be customized, report is a semifinished version, and it takes 4872 hours to upgradePart 1:Terminology Definition, Industry Chain,Industry Dynam...

Waking up (back home) to 2 disappointing trial results this morning. Astra MYSTIC - for all those co’s developing follow-on CTLA-4 assets, this is a very clear message. Chi-Med FALUCA - they’ve been developing Fruquintinib for 11yrs. Science driv

Waking up (back home) to 2 disappointing trial results this morning. Astra MYSTIC - for all those co’s developing follow-on CTLA-4 assets, this is a very clear message. Chi-Med FALUCA - they...

Sobi i miljardaffär med Astra

Köper USA-rättigheterna till Synagis som är den enda godkända förebyggande behandlingen mot RS-virussjukdom hos spädbarn.

Global Dental Anaesthetics Market Status and Outlook 20182025 [Report Updated: 19082018] Prices from USD $4000

Report SnapshotKey Content of Chapters Including and can be customized, report is a semifinished version, and it takes 4872 hours to upgradePart 1:Terminology Definition, Industry Chain,Industry Dynam...

Companies [4 Associated Companies listed on BioPortfolio]

GTS Medical Translation Services

GTS provides certified medical translation services to leading pharmaceutical companies, medical device companies and CROs. Customers include Astra Zeneca, GSK, Teva Pharmaceuticals, Siemens, Boston...

Astra Tech Inc.

Astra Tech AB, a company in the Astra Zeneca group, is a global leader in dental, surgical and urological products, services and support. An innovation-driven company since the st...

DENTSPLY Implants

DENTSPLY Implants is the union of two successful and innovative dental implant businesses: DENTSPLY Friadent and Astra Tech Dental. DENTSPLY Implants offers a comprehensive line o...

Astra Tech AB

The contents of this Web site are copyrighted. Astra Tech and its subsidiaries, members of the AstraZeneca group of companies (collectively, the "Company"), hereby authorize you to copy documents publ...

Clinical Trials [26 Associated Clinical Trials listed on BioPortfolio]

Catheter Directed Interventions in Pulmonary Embolism

Evaluating the safety and outcomes of catheter directed thrombolysis following catheter fragmentation in acute high risk pulmonary embolism

Short vs Long Dental Implants for the Fixed Rehabilitation of the Fully Edentulous Mandible

The aim of this study is to clinically and radiographically compare the performance of short (6 mm-long) versus long (≥11 mm-long) dental implants placed in the interforaminal region of ...

Streptokinase Versus Unfractionated Heparin Nebulization in Severe ARDS

Background: Intra-alveolar clotting and alveolar collapse in ARDS is due to alveolar capillaries epithelial and leakage. Subsequently, collapse induces hypoxemia that is resistant to recru...

Biomaterial to Counteract Ridge Reduction Following the Removal of Multiple Adjacent Teeth.

An open, prospective, randomized, multicenter study focused on the ridge diminution in case of grafting of fresh extraction sockets with Bio-Oss Collagen, Bio-Gide (Geistlich Pharma, Wolhu...

Acute Coronary Syndrome Sri Lanka Audit Project

ACSSLAP is the first island wide audit project in Sri Lanka on ACS.

The Effect of Tranexamic Acid on Uterine Blood Flow After Vaginal Delivery

Postpartum hemorrhage is the most common cause of maternal death across the world, responsible for more than 25% of maternal deaths annually. Although effective tools for prevention and tr...

The Influence of Mucosal Tissue Thickness on Soft and Hard Tissue Changes Around Implants

Crestal bone and soft tissue stability around implants is an important issue in implant dentistry. Initial vertical mucosal tissue thickness was shown to be one of the factors having impac...

PROGRESSive Withdrawal Esomeprazole and Acid-related Symptoms

Objectives: To compare the prevalence of clinical symptoms of stomach problems between patients with progressive discontinuation (one week of esomeprazole, 20mg, then discontinuation) or ...

Dimensional Alterations of the Edentulous Ridge Following Removal of Multiple Adjacent Teeth

The objective of the present study is to evaluate if loss of multiple adjacent teeth will cause proportionally greater tissue diminution than the loss of single teeth the possibility of co...

Study to Evaluate an Implant With a Sloped Top in Patients With a Sloped Jaw Bone

The study aims to evaluate maintenance of lingual/palatinal marginal bone with the (ASTRA TECH Implant System) OsseoSpeed™ Profile implant in sites where the alveolar crest anatomy is sl...

Medical and Biotech [MESH] Definitions

Streptococcal fibrinolysin . An enzyme produced by hemolytic streptococci. It hydrolyzes amide linkages and serves as an activator of plasminogen. It is used in thrombolytic therapy and is used also in mixtures with streptodornase (STREPTODORNASE AND STREPTOKINASE). EC 3.4.-.

A mixture of the enzymes (streptokinase and streptodornase) produced by hemolytic streptococci. It is used topically on surface lesions and by instillation in closed body cavities to remove clotted blood or fibrinous or purulent accumulations. It is also used as a skin test antigen in evaluating generalized cell-mediated immunodeficiency. (Dorland, 27th ed) EC 3.-.

An acylated inactive complex of streptokinase and human lysine-plasminogen. After injection, the acyl group is slowly hydrolyzed, producing an activator that converts plasminogen to plasmin, thereby initiating fibrinolysis. Its half-life is about 90 minutes compared to 5 minutes for TPA; (TISSUE PLASMINOGEN ACTIVATOR); 16 minutes for UROKINASE-TYPE PLASMINOGEN ACTIVATOR and 23 minutes for STREPTOKINASE. If treatment is initiated within 3 hours of onset of symptoms for acute myocardial infarction, the drug preserves myocardial tissue and left ventricular function and increases coronary artery patency. Bleeding complications are similar to other thrombolytic agents.

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