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Uveitis - Biotech, Pharma and Life Science Channel

23:01 EST 21st November 2017 | BioPortfolio

There are many different types of Uveitis. This is because:

* The Uvea is made up of different parts. So if the iris is affected, the condition and its treatment could be totally different to when the choroid is affected.
* The inflammation in the Uvea very often affects other parts of the eye such as the retina and so a variety of other problems can be present to complicate the picture.
* there are a large number of medical conditions where Uveitis is a feature amongst the other symptoms of the disease, eg Behcet's Disease, Sarcoidosis and Toxoplasmosis, to name just three of them.
* There are many different types of causes of Uveitis (see Causes of Uveitis below).

The term intraocular inflammation is often used to cover the spectrum of uveitis conditions. As there is this wide variety of different conditions and complications, it follows that there are numerous ways that it presents itself. The degree and type of sight loss and the type of treatment may vary considerably from patient to patient.
 

Uveitis may result from an infection such as a virus (eg herpes), fungus (eg histoplasmosis) or a parasite such as toxoplasmosis. It may be related to Autoimmune Disease (with or without involvement of other parts of the body). Trauma to the eye, or even the other eye in the past, can lead to Uveitis. The word "idiopathic" may often be used to describe this group.

Another important way of classifying the different types of Uveitis is by describing the part of the eye that is affected.
*Anterior Uveitis; affecting the front of the eye, normally the iris (iritis) or the ciliary body (iridocyclitis). Iritis is by far the most common type of Uveitis and also the most readily treated. Close monitoring is needed because complications such as raised eye pressure and cataracts can occur.
*Intermediate Uveitis; affecting the area just behind the ciliary body (pars plana) and also the most forward edge of the retina. This is the next most common type of Uveitis.                                                                                                                                                                                  *Posterior Uveitis; when the inflammation affects the part of the uvea at the back of the eye, the choroid. Often the retina is affected much more in this group.

Like the varied nature of Uveitis, the treatment of it may differ from case to case quite considerably. Corticosteroids are often the mainstay of treatment but now are, importantly, being joined by some other newer drugs, usually used along with the steroids. Various eye-drops are used, particularly to treat Anterior Uveitis. There is a growing confidence, especially with the newer drug treatments, that the eyesight can be stabilised over the long term. Uveitis as a disease should be regarded as incurable in the sense that it will never completely go away, but that is not to say that it can not be controlled. Uveitis is estimated to be responsible for approximately 10% of the blindness in the United States.

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PubMed Articles [118 Associated PubMed Articles listed on BioPortfolio]

Update on the Treatment of Uveitis in Patients with Juvenile Idiopathic Arthritis: A Review.

Chronic uveitis is a common extra-articular manifestation of juvenile idiopathic arthritis. The classic clinical picture is one of chronic anterior uveitis, which usually remains asymptomatic until oc...

Comprehensive analysis of vitreous specimens for uveitis classification: a prospective multicentre observational study.

To determine the clinical relevance of vitreous biomarkers in patients with uveitis.

SAFETY OF CONSECUTIVE SAME-DAY BILATERAL INTRAVITREAL DEXAMETHASONE IMPLANT (OZURDEX).

The objective of this study was to evaluate patient safety and tolerance of consecutive bilateral intravitreal dexamethasone (Ozurdex) injections during a single visit for the treatment of cystoid mac...

Diagnostic Value of Serum-Soluble Interleukin 2 Receptor Levels vs Angiotensin-Converting Enzyme in Patients With Sarcoidosis-Associated Uveitis.

New and improved diagnostic tests for sarcoidosis-associated uveitis are needed because the currently available laboratory diagnostic biomarkers (eg, lysozyme and angiotensin-converting enzyme [ACE]) ...

Sarcoid, Bayes, and the Challenges of Laboratory Testing for Uveitis.

OUTCOMES OF PARS PLANA VITRECTOMY FOR MACULAR HOLE IN PATIENTS WITH UVEITIS.

Inflammatory macular hole is a rare complication of uveitis, and data on surgical outcomes of closure are scarce. The purpose of this study is to evaluate the anatomical and visual outcomes of convent...

Safety of weekly adalimumab in the treatment of juvenile idiopathic arthritis and pediatric chronic uveitis.

Weekly adalimumab dosing is used to treat juvenile idiopathic arthritis (JIA), uveitis, and other pediatric rheumatic diseases, but the safety of such dosing has not previously been studied. A retrosp...

Tuberculosis and other causes of uveitis in Indonesia.

PurposeThe purpose of this study is to assess the causes of uveitis in Indonesia and determine the importance of tuberculosis (TB) as a cause of uveitis.Patients and methodsProspective cohort study ex...

Ten-Year Retention Rate of Infliximab in Patients with Behçet's Disease-Related Uveitis.

To evaluate the 10-year drug retention rate of infliximab (IFX) in Behçet's disease (BD)-related uveitis, the effect of a concomitant use of disease modifying anti-rheumatic drugs (DMARDs) on drug su...

Autoreactive T Cells in Immunopathogenesis of TB-Associated Uveitis.

Intraocular inflammation in tuberculosis-associated uveitis (TBU) is usually widespread, and responds unpredictably to treatment. Herein, we analyze the intraocular T-cell response in TBU for its surf...

News Articles [62 Associated News Articles listed on BioPortfolio]

Uveitis Epidemiology Forecast to 2025 [Report Updated: 10112017] Prices from USD $2360

DelveInsight's Uveitis Epidemiology Forecast, 2025 provides an overview of the epidemiology trends of Uveitis in seven major markets US, France, Germany, Italy, Spain, UK and Japan. It includes 10 ...

Complement C5 C3 And PZP Like Alpha 2 Macroglobulin Domain Containing Protein 4 or C5 Pipeline Review, H2 2017 [Report Updated: 10102017] Prices from USD $3500

Complement C5 C3 And PZP Like Alpha 2 Macroglobulin Domain Containing Protein 4 or C5 Pipeline Review, H2 2017SummaryComplement C5 C3 And PZP Like Alpha 2 Macroglobulin Domain Containing Protein 4 or...

Uveitis Epidemiology Forecast to 2025 [Report Updated: 10102017] Prices from USD $2950

DelveInsight's Uveitis Epidemiology Forecast, 2025 provides an overview of the epidemiology trends of Uveitis in seven major markets US, France, Germany, Italy, Spain, UK and Japan. It includes 10 ...

Galapagos NV: Galapagos Q3: clinical success with GLPG1690 and MOR106 highlights strength of deep pipeline

Substantial progress in R&D Inflammation: Studies with filgotinib started in uveitis and lupus membranous nephropathy IL-17C antibody MOR106 showed promising signs of activity in atopic dermatitis...

Tx for Allergic Conjunctivitis Falls Short: Ophthalmology Times

(MedPage Today) -- Also, new treatment for pediatric anterior uveitis

World Drug and Medication: Uveitis Pipeline Review H2

LONDON, Oct. 9, 2017 /PRNewswire/ -- SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Uveitis - Pipeline Review, H2 2017, provides an overview of the Uveitis ...

Panoptes Pharma GesmbH Pharmaceuticals Healthcare Deals and Alliances Profile [Report Updated: 13092017] Prices from USD $250

SummaryPanoptes Pharma GesmbH Panoptes Pharma is a biotechnology company that develops small molecule based therapies to treat severe eye diseases such as autoimmune uveitis, adenoviral conjunctivitis...

Cataract Surgery in Uveitis: A Multicentre Database Study

This study explores the outcome of cataract surgery in patients with uveitis. How is visual acuity impacted? The British Journal of Ophthalmology

Elevated IOP, glaucoma complications of herpetic anterior uveitis

A study confirmed that elevated IOP and secondary glaucoma are frequent complications of herpetic anterior uveitis and that the number of IOP peaks is correlated with the risk for glaucoma.The medical...

Aldeyra nets $27mm via FOPO

Aldeyra Therapeutics Inc. (developing therapies for diseases related to endogenous aldehyde toxicity) netted $27mm through the follow-on offering of 3.97mm common shares (including full exercise of th...

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Companies [4 Associated Companies listed on BioPortfolio]

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Lux Biosciences, Inc.

Lux Biosciences, Inc. is a privately held biotechnology company focused on the treatment of ophthalmic diseases. Lux Biosciences has exclusive worldwide rights to voclosporin for ...

Clinical Trials [131 Associated Clinical Trials listed on BioPortfolio]

Immunologic Markers for the Differential Diagnosis Between Uveitis-TBC and Uveitis-SARC (TBC-SARC)

Today there are no tests that allow to make a precise differential diagnosis between uveitis from presumed tuberculous origin and uveitis by sarcoidosis. Therefore, with this study, we aim...

Evaluation of EYS606 in Patients With Non-infectious Posterior, Intermediate or Panuveitis

Primary objective: safety and tolerability Secondary objectives: additional indicators of long term safety and indicators of clinical activity Exploratory objectives: to characteri...

Trabeculectomy With MMC and I Stent in Uveitic Glaucoma and POAG : Outcomes and Prognostic Factors

1. determine whether cataract surgery has a major effect on outcomes of trabeculectomy with MMC or not. 2. Success rates of trabeculectomy with MMC in Queen Elizabeth hospital. ...

CLArithromycin Versus AZIthromycin in the Treatment of Mycobacterium Avium Complex (MAC) Lung Infections

MAC lung infections are a growing public health problem. The ATS / IDSA 2007 guidelines for the treatment of these non-tuberculous mycobacterial infections recommend the use of a macrolide...

Patient Registry of Posner-Schlossman Syndrome

Posner-Schlossman syndrome, or glaucomatocyclitic crisis, is a condition characterized by recurrent, acute attacks of mild, nongranulomatous, anterior uveitis accompanied by markedly eleva...

Interferon α2a Versus Cyclosporine for Refractory Behçet`s Disease Uveitis

Brief summary: This study compares the long-term efficacy and safety of interferon (IFN) α2a and cyclosporine (cyclosporin A, CsA) following suppression of acute attack by high-dose oral ...

Efficacy and Safety of Filgotinib in Adults With Active Non-Infectious Uveitis

The primary objective of this study is to evaluate the efficacy of filgotinib versus placebo for the treatment of the signs and symptoms of non-infectious uveitis in participants failing t...

RNFL Thickness Measurements Obtained Using SD-OCT and SLP Using GDx Variable Corneal Compensation

The aim of this study is to evaluate the correlation of retinal nerve fiber layer (RNFL) thickness measured using spectral domain optical coherence tomography (SD-OCT) and scanning laser p...

Chronic Inflammatory Disease, Lifestyle and Treatment Response

Chronic inflammatory diseases (CID) - including inflammatory bowel diseases (Crohn's disease and ulcerative colitis), rheumatic conditions (rheumatoid arthritis, axial spondyloarthritis, p...

Suprachoroidal Injection of CLS-TA in Subjects Non-infectious Uveitis

Open-label safety study of suprachoroidal triamcinolone acetone injectable suspension in patients with non-infectious uveitis.

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Medical and Biotech [MESH] Definitions

Human histocompatibility (HLA) surface antigen encoded by the B locus on chromosome 6. It is strongly associated with acute anterior uveitis (UVEITIS, ANTERIOR); ANKYLOSING SPONDYLITIS; and REACTIVE ARTHRITIS.

Inflammation of the choroid as well as the retina and vitreous body. Some form of visual disturbance is usually present. The most important characteristics of posterior uveitis are vitreous opacities, choroiditis, and chorioretinitis.

Abnormally low intraocular pressure often related to chronic inflammation (uveitis).

Inflammation of the pars plana, ciliary body, and adjacent structures.

Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina). (Dorland, 27th ed)

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