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Variant Forms of Lupus - Biotech, Pharma and Life Science Channel

08:02 EST 22nd November 2017 | BioPortfolio

PubMed Articles [4270 Associated PubMed Articles listed on BioPortfolio]

Observations using Phosphorus-31 nuclear magnetic resonance ((31)P-NMR) of structural changes in freeze-thawed hen egg yolk.

Hen egg yolk (EY) has a complicated structure consisting of lipids and proteins, and its structure is deeply related with its functional properties. (31)P-NMR is an efficient technique to non-destruct...

Nonalcoholic Fatty Liver Disease and Metabolic Syndrome.

Nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) are highly prevalent, affecting approximately one-third of the US population. The relationship between NAFLD and MS is complex and ...

Risk of Serous Endometrial Carcinoma in Women With Pathogenic BRCA1/2 Variant After Risk-Reducing Salpingo-Oophorectomy.

It has recently been shown that the risk of a rare subtype of endometrial carcinoma (serous type) in women carrying a germline BRCA1/2 pathogenic variant is increased. We assessed the incidence of ser...

Folates biosynthesis by Streptococcus thermophilus during growth in milk.

The ability of folate-producer strains of Streptococcus thermophilus to accumulate folates and the expression of two target genes (folK and folP), involved in the folate biosynthesis, were studied dur...

Murine Models for Viral Hemorrhagic Fever.

Hemorrhagic fever (HF) viruses, such as Lassa, Ebola, and dengue viruses, represent major human health risks due to their highly contagious nature, the severity of the clinical manifestations induced,...

Analysis of Glutathione in Biological Samples by HPLC Involving Pre-Column Derivatization with o-Phthalaldehyde.

Glutathione (GSH) forms conjugates with polyamines in prokaryotes and eukaryotes. There is also evidence suggesting cross-talk between GSH and polyamines to regulate cellular homeostasis and function,...

Polyamines and Cancer.

This chapter provides an overview of how the polyamine pathway has been exploited as a target for the treatment and prevention of multiple forms of cancer, since this pathway is disrupted in all cance...

Nonradioactive Isotopic Labeling and Tracing of Selenoproteins in Cultured Cell Lines.

Selenium (Se) is an essential component of genetically encoded selenoproteins, in the form of a rare amino acid, namely the selenocysteine (Sec). Radioactive (75)Se has been widely used to trace selen...

Preparation of Selenocysteine-Containing Forms of Human SELENOK and SELENOS.

Selenoprotein K (SELENOK) and Selenoprotein S (SELENOS) are the members of the endoplasmic-reticulum-associated degradation (ERAD) complex, which is responsible for translocating misfolded proteins fr...

Monitoring of Methionine Sulfoxide Content and Methionine Sulfoxide Reductase Activity.

The sulfur-containing amino acid methionine (Met) plays critical roles in protein synthesis, methylation, and sulfur metabolism. Both in its free form and in the form of an amino acid residue, it can ...

News Articles [934 Associated News Articles listed on BioPortfolio]

Global Patchouli Oil Market Data List by Segment 20152022 [Report Updated: 10112017] Prices from USD $800

SnapshotKLH, which can be used as an active pharmaceutical ingredient API, is a very large, high molecular weight, oxygencarrying glycoprotein made of millions of atoms. There are two KLH subunit form...

New insights into the pharmacogenomics of antidepressant response from the GENDEP and STAR*D studies: rare variant analysis and high-density imputation

The PNPLA3 I148M variant is associated with transaminase elevations in type 2 diabetes patients treated with basal insulin peglispro

Alzheimer's Tau protein forms toxic complexes with cell membranes

(Ecole Polytechnique Fédérale de Lausanne) Alzheimer's disease is caused by tangles in the brain made up of malfunctioning aggregated Tau proteins. Scientists at EPFL have discovered a new toxic for...

PTSD: An Overlooked Consequence of a Cancer Diagnosis

Roughly one in five cancer patients struggle with post traumatic stress disorder (PTSD) in the aftermath of diagnosis and treatment. A recent study from Malaysia indicates that PTSD is a fairly comm...

Global and Regional Malic Acid Market Research Report 2017 [Report Updated: 09102017] Prices from USD $3500

SummaryMalic acid is an organic compound with the formula C4H6O5. It is a dicarboxylic acid that is made by all living organisms, contributes to the pleasantly sour taste of fruits, and is used as a f...

VIDEO: Atacicept is a 'potential, exciting' treatment for lupus

SAN DIEGO — At the American College of Rheumatology Annual Meeting, Joan Merrill, MD, spoke about a study that she said is further demonstration that atacicept should continue being developed as a p...

XTL Biopharmaceuticals Ltd XTLB Financial and Strategic SWOT Analysis Review [Report Updated: 13112017] Prices from USD $300

SummaryXTL Biopharmaceuticals Ltd XTL is a biopharmaceutical company that offers acquisition, development and commercialization of pharmaceutical products and latestage pharmaceutical product candidat...

Sodium Sulfate Market - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast ...

Global Sodium Sulfate Market: Overview Sodium sulfate is available in two forms in nature, dehydrate and anhydrous. Dehydrate form is produced from mirabilite and is Read more...

For infants with heart disease, are shunts or stents better to maintain blood flow?

(Children's Hospital of Philadelphia) Infants with various forms of congenital heart disease require a stable source of blood flow to their lungs in order to survive until a more definitive operation ...

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Companies [117 Associated Companies listed on BioPortfolio]

Twist Bioscience

At Twist Bioscience, our expertise is accelerating science and innovation by leveraging the power of scale. We have developed a proprietary semiconductor-based synthetic DNA manuf...

Sun Pharmaceutical Industries Ltd.

Established in 1983, listed since 1994 and headquartered in India, Sun Pharmaceutical Industries Ltd. (Reuters: SUN.BO, Bloomberg: SUNP IN, NSE: SUNPHARMA, BSE: 524715) is an inte...

Bormioli Rocco Pharma

Bormioli Rocco Pharma exclusively serves the pharmaceutical and biopharmaceutical market with integrated glass and plastic containers, closures and accessories for packaging, usin...

Formstack

Formstack is a versatile online form solution that streamlines processes for capturing and managing information. With Formstack, businesses and teams of all types and sizes can ea...

Alpine Immune Sciences, Inc.

Alpine Immune Sciences, Inc. was founded in 2015 and is focused on developing novel protein‐based immunotherapies using its proprietary variant immunoglobulin domain (vIgD) p...

Samumed, LLC

Based in San Diego, CA, Samumed (www.samumed.com) is a pharmaceutical platform company focused on advancing regenerative medicine and oncology applications through research and in...

Halo Pharmaceutical

Halo Pharmaceutical, headquartered in Whippany, NJ, is a specialty pharmaceutical company engaged in pharmaceutical branded product lifecycle management. The company's strategy is to acquire products ...

Binary Fountain, Inc.

Binary Fountain is a leading social intelligence company that extracts operational feedback from online conversations and distills the results into actionable insights. The compan...

AgTech Accelerator

AgTech Accelerator, established in 2016 in Research Triangle Park, is a venture development organization focused on discovering and developing emerging agricultural technology and...

Fabric Genomics

Fabric GenomicsTM is a computational genomics company offering end-to-end genomic data analysis, annotation, curation, classification and reporting solutions ...

Clinical Trials [1079 Associated Clinical Trials listed on BioPortfolio]

Scrutinizing the Heterogeneity of SLE: Defining Phenotypes

SLE disease course is characterized by unpredictable relapses and remissions in the majority of patients. However, in a small proportion (approximately 5%), SLE presents with a monophasic ...

Study and Follow-up of Multiple Endocrine Neoplasia Type 1

Multiple Endocrine Neoplasia type I (MEN1) or Wermer syndrome is an autosomal dominant disease that predisposes patients to the development of endocrine tumours, principally parathyroid, p...

Cognitive Abilities in Brain Damaged Patients

The presence of damage to the central and / or peripheral nervous system resulting from pathologies of a different nature (such as multiple sclerosis, Parkinson's disease, dementia, crania...

Immunologic Markers for the Differential Diagnosis Between Uveitis-TBC and Uveitis-SARC (TBC-SARC)

Today there are no tests that allow to make a precise differential diagnosis between uveitis from presumed tuberculous origin and uveitis by sarcoidosis. Therefore, with this study, we aim...

Minnelide in Adult Patients With Relapsed or Refractory Acute Myeloid Leukemia

Minnelide, a water-soluble disodium salt variant of triptolide, is a diterpenoid heat shock protein 70 (HSP70) inhibitor. Studies using AML cell lines, primary patient samples, and mouse t...

Safety and Tolerability Study Of PF-06835375 In Subjects With Seropositive Systemic Lupus Erythematosus Or Rheumatoid Arthritis

This is a Phase 1 single and multiple dose escalation study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of PF-06835375 in subjects with seropositive SLE or...

Mitochondrial Function in Transthyretin Amyloidosis

Hereditary (familial) amyloidosis arising from the misfolding of a mutated or variant transthyretin, is the most frequent form of amyloid cardiomyopathy in the Caribbean basin. Affected or...

A Pilot Functional Performances Study of Two Synthetic Male Condom

Over the decades, male condoms had been widely commercialized and used to protect against unintended pregnancy and sexually transmitted infections (STI). While natural rubber latex (NRL) m...

Quadratus Lumborum Block vs Transversus Abdominis Plane Block for Post-cholecystectomy Analgesia

In laparoscopic cholecystectomy, overall pain is a conglomerate of three different and clinically separate components: incisional pain (somatic pain) due to trocar insertion sites, viscera...

Study of The Association of Mutations in The NPHS2 Gene and Nephrotic Syndrome in Children and Adults in Middle East

Nephrotic syndrome (NS) represents one of the most common diagnoses in pediatric and adult nephrology, with a prevalence of 16 per 100,000 children and 3 per 100,000 adults in Western coun...

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Medical and Biotech [MESH] Definitions

A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).

Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).

A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.

The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).

An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.

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