Advertisement

Topics

Virulence Factors - Biotech, Pharma and Life Science Channel

01:32 EDT 19th October 2017 | BioPortfolio

Virulence factors are molecules expressed and secreted by pathogens (bacteria, viruses, fungi and protozoa) that enable them to achieve the following:

* colonization of a niche in the host (this includes adhesion to cells)
* Immunoevasion, evasion of the host's immune response
* Immunosuppression, inhibition of the host's immune response
* entry into and exit out of cells (if the pathogen is an intracellular one)
* obtain nutrition from the host.

Virulence factors are very often responsible for causing disease in the host as they inhibit certain host functions.

Adherence Factors: Many pathogenic bacteria colonize mucosal sites by using pili (fimbriae) to adhere to cells.

Invasion Factors: Surface components that allow the bacterium to invade host cells can be encoded on plasmids, but more often are on the chromosome.

Capsules: Many bacteria are surrounded by capsules that protect them from opsonization and phagocytosis.

Endotoxins: The lipopolysaccharide endotoxins on Gram-negative bacteria cause fever, changes in blood pressure, inflammation, lethal shock, and many other toxic events.

Exotoxins: Exotoxins include several types of protein toxins and enzymes produced and/or secreted from pathogenic bacteria. Major categories include cytotoxins, neurotoxins, and enterotoxins.

Siderophores: Siderophores are iron-binding factors that allow some bacteria to compete with the host for iron, which is bound to hemoglobin, transferrin, and lactoferrin.

Source; NCBI

PubMed Articles [9469 Associated PubMed Articles listed on BioPortfolio]

Model for Listeria monocytogenes inactivation by high hydrostatic pressure processing in Spanish chorizo sausage.

A central composite design was implemented to study the effect of three factors on HHP-induced L. monocytogenes inactivation in Spanish chorizo sausage, in order to increase its effectiveness: produc...

Unravelling the contribution of the Penicillium expansum PeSte12 transcription factor to virulence during apple fruit infection.

Blue mould disease caused by Penicillium expansum infection is one of the most important diseases of pome fruit accounting for important economic losses. In the present study, the PeSte12 transcriptio...

A Primary Human Liver Cell Culture Model for Hemorrhagic Fever Viruses.

Viral hemorrhagic fevers affect liver functions such as important metabolic processes and the replacement of new blood cells, coagulation factors, and growth factors. Typically, multi-organ diseases s...

Identifying Restriction Factors for Hemorrhagic Fever Viruses: Dengue and Junín.

Host restriction factors are cellular components that interfere with viral multiplication. They are up-regulated and expressed upon viral infection and in consequence their activity is specific. So fa...

The Role of CD44 and Cancer Stem Cells.

Solid tumors are composed of mutually interacting cancer cells and tumor microenvironment. Many environmental components, such as extracellular matrix (ECM), mesenchymal stem cells, endothelial and im...

In Vitro Tumorigenic Assay: The Tumor Spheres Assay.

Cancer stem cells (CSCs) are a subpopulation of cells within cancer tissues that are thought to mediate tumor initiation. CSCs are furthermore considered the cause of tumor progression and recurrence ...

Tumor Tissue Analogs for the Assessment of Radioresistance in Cancer Stem Cells.

Over the years, radiotherapy-related research has been based on local tumor control as an experimental endpoint, yielding a wealth of data demonstrating the importance of cancer stem cells in tumor re...

Plant Gene Regulation Using Multiplex CRISPR-dCas9 Artificial Transcription Factors.

Besides genome editing, the CRISPR-Cas9-based platform provides a new way of engineering artificial transcription factors (ATFs). Multiplex of guide RNA (gRNA) expression cassettes holds a great promi...

The N-butyl-N-4-hydroxybutyl Nitrosamine Mouse Urinary Bladder Cancer Model.

Urinary bladder cancer (UBC) is a common and complex malignancy, with a multifactorial etiology, like environmental factors, such as cigarette smoking, occupational exposure, and genetic factors.UBC e...

In Vitro Translation Assays for Selenocysteine Insertion.

The molecular characterization of the protein and RNA factors that are required for Sec incorporation in mammals has been largely carried out using in vitro translation systems specifically modified f...

News Articles [1321 Associated News Articles listed on BioPortfolio]

Non-Familial ALS: A tangled web

Research ranging in scale from cells to populations is rapidly closing in on what goes awry in the body in 'non-familial' ALS, and what environmental factors might contribute.

Episona adds D2C model for male fertility test using epigenetics

Seed is a next-generation sequencing test that identifies signs of DNA methylation in sperm as the result of aging, smoking, pollution and other factors.

Stent Outcomes Not So Different Across Sexes, Races

(MedPage Today) -- But study finds social factors that do make a difference

Medical News Today: All you need to know about epiretinal membrane

A look at the condition epiretinal membranes (ERMs). We examine the risk factors and complications, along with how to prevent the condition, here.

How can we make a best guess with incomplete information?

I have spent three days at the Society to Improve Diagnosis in Medicine. Whenever I come to this meeting, I have insights from listening to talks and many conversations with leaders in the field. When...

Researchers take to tech to study toxic cyanobacteria with $1.47M NASA grant

(Cary Institute of Ecosystem Studies) With support from a $1.47 million grant from the National Aeronautics and Space Administration (NASA), an interdisciplinary team of researchers from the Cary Inst...

Superior vena cava(SVC)-derived atrial fibrillation attributes clinical and genetic factor

(Tokyo Medical and Dental University) The genetic factors associated with atrial fibrillation (AF), a condition characterized by irregular heartbeat that can lead to heart failure, have never been ide...

Radiologic Factors Associated with Rapid Stroke Progression

For patients with radiologic evidence of poor collateral circulation, interventional treatment may be futile.

CMS Offers Guidance on Inpatient Engagement Necessary for Hospital Certification

The new guidance highlights two key factors that surveyors should consider: average length of stay (ALOS) and average daily census (ADC).

Just Which Patients Are at Risk of Developing Uterine Fibroids?

Uterine fibroids occur commonly and are the most frequent reason for hysterectomy in the United States. Recognizing the risk factors for developing fibroids can help clinicians identify affected indiv...

Events [0 Results]

None

Companies [49 Associated Companies listed on BioPortfolio]

GI Dynamics

GI Dynamics is focused on developing effective, non-surgical approaches for treating type 2 diabetes and obesity. The company’s patented EndoBarrier™ Technology has the ...

PuppySpot

PuppySpot’s mission is to make lives better by placing healthy puppies into happy homes. Based upon a fundamental belief that finding a puppy does not have to come with so ma...

Histogen, Inc.

Histogen is a regenerative medicine company developing innovative products from cells grown under simulated embryonic conditions, including low oxygen and suspension. Through this...

The Lisa Colagrossi Foundation

The Lisa Colagrossi Foundation (TLCF) is the leader in raising awareness and education to help diagnose and treat brain aneurysms. TLCF's primary focus is to communicate the si...

RF IDeas Inc.

RF IDeas, founded in 1995, is the innovator of WaveID®, the new standard for badge-based authentication and identification solutions powered by RF IDeas readers. Under the Wave...

Telephus Medical LLC

Telephus Medical, located in San Diego, California, is developing a suite of monoclonal antibody products designed to neutralize key staphylococcal enzymes used to attach to host ...

Design SHIFT

Design SHIFT is a Menlo Park-based product design firm founded in 2009 with the simple idea that with passion and focus, small teams can deliver breakthrough products on a global ...

Integra ServiceConnect®, LLC

Integra ServiceConnect® connects people to services they need to improve their health. With the recognition that 80% of health outcomes are driven by non-clinical social factor...

Conceivable

Conceivable is the first modern fertility program that radically improves a woman’s natural ability to get and stay pregnant. The Conceivable program helps women identify, un...

Tenet Healthcare Corporation and Health Net, Inc.

This release contains “forward-looking statements” – that is, statements that relate to future, not past, events. In this context, forward-looking statements often ...

Clinical Trials [1870 Associated Clinical Trials listed on BioPortfolio]

Sleep/Wake Protocol Implementation to Improve Sleep Quality in the ICU

The purpose of this study is to analyze a multi-component sleep/wake protocol for optimization of environmental factors (noise, light, nursing activities) as well as non-environmental fact...

Gestational Diabetes: a Cohort Study

Gestational diabetes (GDM) is the most common hormonal complication during pregnancy. Its occurrence implies an increased risk of maternal and fetal complications and, therefore, its diagn...

The Analysis of Factors Influencing the Vd of Imipenem in Septic Shock Patients

The study measures the plasma concentrations of imipenem in septic shock patients and non-septic shock patients and observes hypoalbuminemia and the impact of the severity of critical illn...

Subjective Factors of Polymedication in the Elderly: a Qualitative Study of the Perceptions of Patients, Relatives and Referent Physicians.(DOSAGE)

The DOSAGE Study is a qualitative transversal study aiming to describe and understand the subjective factors of polymedication in the elderly population (75 years old and more), defined as...

Construction and External Validation of a Predictive Clinico-biological Score of the Risk of Venous Thrombosis in Women Under Combined Oral Contraceptives

the investigators hypothesize that some of these polymorphisms contribute to VTE risk in women using COC, and that their screening could to help assess individual risk of VTE before COC pr...

Influence of Different Parameters on Exhumation Time After Cardiac Surgery.

The aim of this study is to determine which factors could be at risk of delayed extubation after cardiac surgery.

Aortic Stenosis in Subjects With Heterozygous Familial Hypercholesterolemia on Prolonged Treatment With Statins

Aortic stenosis (AE) is a disease that has been increasing steadily in recent years in most countries, including Spain.Risk factors for the development of AE include age, hypercholesterole...

The Effect of Hand Hygiene on Colonization Rates With Multidrug Resistant Enteric Pathogens in Travellers

Travelling to tropical and subtropical countries is a known risk factor for becoming colonized with extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae. Especially travell...

Fibrinogen Concentrate in Isolated Traumatic Brain Injury

Fibrinogen is a unique precursor of fibrin and cannot be compensated for by other coagulation factors. If plasma fibrinogen concentrations are insufficient, hemostatic clots cannot be form...

Prognostic Factors in Zygapophyseal Osteoarthritis Infiltration: a Prospective Cohort Study

Magnet Resonance Image findings of facet osteoarthritis and patient characteristics are prognostic factors for improvement or worsening of the clinical outcome after treatment with facet i...

Videos

None available.

Medical and Biotech [MESH] Definitions

The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.

One of the virulence factors produced by BORDETELLA PERTUSSIS. It is a multimeric protein composed of five subunits S1 - S5. S1 contains mono ADPribose transferase activity.

One of the virulence factors produced by virulent BORDETELLA organisms. It is a bifunctional protein with both ADENYLATE CYCLASE and hemolysin components.

Infections resulting from the use of catheters. Proper aseptic technique, site of catheter placement, material composition, and virulence of the organism are all factors that can influence possible infection.

Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. Two classes have been characterized: TOXINS, BIOLOGICAL and surface adhesion molecules that effect the ability of the microorganism to invade and colonize a host. (From Davis et al., Microbiology, 4th ed. p486)

Quick Search
Advertisement
 

Relevant Topics

Women's Health
Women's Health - key topics include breast cancer, pregnancy, menopause, stroke Follow and track Women's Health News on BioPortfolio: Women's Health News RSS Women'...

Bioinformatics
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...

Nutrition
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...

review and buy Virulence Factors market research data and corporate reports here

Channels Quicklinks