Clinical Research Organization Clinical Trials

09:51 EST 18th December 2018 | BioPortfolio

A Prospective Study to Monitor Liver Diseases Dynamically by Ultrasound Viscoelasticity

The accuracy of ultrasound elastography for assessing liver fibrosis by measuring liver stiffness (elastic modulus) is better than traditional method. Elastography has certain advantage such as non-invasive, simple, real-time and it has been recommended by clinical guidelines. However, some chanllenging scientific problems showed up with further research and clinical ...

Exploratory Study of Cereset Research

The purpose of this study is to evaluate the use of Cereset Research to improve autonomic function in participants with neurological, cardiovascular, or psychophysiological conditions, or those who are caregivers or first responders.

AZD6738 for Patients With Progressive MDS or CMML

This research study is studying a research drug called AZD6738 as a possible treatment for Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia .

Non-interventional Research Clinical Research Program for Establishment of Milk Protein Allergy Oral Immune Tolerance

The main purpose of this study was to observe the effect of amino acid formula powder on alleviating food allergies in infants; to evaluate the role of food avoidance and open-ended stimulation test in the diagnosis of food-allergic infants; to observe the allergic process in children with food allergy and to explore the criteria for diagnosis and treatment. The baby here r...

Suvorexant (Belsomra) for the Treatment of Bipolar Depression With Insomnia

The investigators are doing this research study to find out if suvorexant (Belsomra) can help people with bipolar depression when added to their usual treatment. The investigators also want to find out if suvorexant (Belsomra) is safe to take without causing too many side effects in people with bipolar disorder. Suvorexant (Belsomra) is approved by the U.S. Food and Drug A...

Hypertension Management in Young Adults Personalised by Echocardiography and Clinical Outcome.

HyperEcho is a multi-centre longitudinal observational study, to investigate whether baseline transthoracic echocardiography along with routine data collected in the hypertension clinic can guide clinicians to better manage, and improve risk stratification for cardiovascular disease in young adults with hypertension. Participants are characterised as young adult patients ag...

Multicenter Prospective Cohort Study of Risk Factors for Gallbladder Cancer

This trial is a prospective study, the main purpose of the study is to investigate the association between benign gallbladder disease and gallbladder carcinoma; to explain the timing of intervention, intervention and early prevention of benign gallbladder disease; according to the national epidemiology of gallbladder cancer Center Clinical Research (unpublished), 2000 Natio...

Clinical and Economical Evaluation of Colorectal Surgery in Ambulatory Care

Enhanced recovery after surgery (ERAS) significantly decreases mortality, morbidity and hospital length of stay without increasing the rate of re-hospitalization. It reduces psychologic stress caused by surgery and decreases postoperative complications about 50 %, especially in colorectal surgery. ERAS is now the object of several Good Practices Recommendations and is about...

Sust-AIns: Sustainment of Suicide Prevention Programs in American Indian Settings

The proposed study is part of the research project for a National Institute of Mental Health K01 grant to Dr. Haroz. The overall research project is focused on understanding how to sustain evidenced-based mental and behavioral health programs in tribal contexts. The aim of this study is to pilot test sustainment strategy interventions across tribal settings using mixed-meth...

Environment Analysis Inside an Investigational Prescription Bottle

The purpose of the study is to test a research prescription bottle that will monitor the physical environment inside the bottle.

A Study of the Role of Circulating Tumor DNA in Predicting the Likelihood of Organ Preservation After Clinical Complete Response to Neoadjuvant Therapy for Rectal Cancer

In this research study, the investigators are looking to see if the circulating tumor DNA (genetic material), also known as ctDNA, in the blood will help them predict whether the participant's cancer will come back.

Prospective Study of the Prosigna Assay on Neoadjuvant Clinical Decision-making in Women With HR+/Her2- Breast Cancer

This research study is evaluating a genomic analysis called Predictor Analysis of Microarray 50 (PAM50, by Prosigna®) as a tool to possibly guide the participant and the treating physician to choose the most personalized pre-operative treatment for breast cancer.

Can Electronic Information Kiosks Enhance Patient Accrual for Cancer Clinical Trials? A Pilot and Feasibility Study

The proposed study will include patients with non-haematologic cancer. Eligible patients will be invited to consent for participation in our study using standard demographic data collection forms and patient satisfaction questionnaires. Cancer patients interested in learning more about clinical trials would be invited to go to the kiosk. A summer student approved and hired...

MOCHA Moving Forward: a CBPR Investigation of Chronic Disease Prevention in Older, Low-income African-American Men

The overall goal of the research is to discover how to reduce chronic disease health disparities among older (ages 35-70) low-income African-American men more effectively. To achieve this goal, we are conducting formative exploratory research with middle-aged, low-income African-American men; testing two versions of a novel community-developed intervention, MOCHA and MOCHA+...

The Effectiveness of Global Postural Reeducation on Alzheimer Disease Patients

This research study is developed on an experimental design with non-randomized controlled interventions were participated 135 subjects with AD including 45 of the control group. It lasted 6 months with pre-post tests (T0-T1) executed before and after six months of treatment. By having in focus the evaluation of GPR therapy effects on cognitive, proprioceptive, depressive, a...

Investigation of the Effects of Clinical Pilates Exercises on Primary Caregivers of Special Needs Children

The aim of this research is to investigate the effectiveness of clinical Pilates exercises applied to primary caregivers of children with special needs, flexibility, muscle strength, endurance, cardiovascular endurance, fatigue, coping attitudes and quality of life, depression and anxiety.

Effects of Intraoperative Stimulation of Acupoints on Postoperative Gastrointestinal Motility Recovery

1. Research name: Effects of intraoperative stimulation of acupoints on postoperative gastrointestinal motility recovery in patients undergoing non-gastrointestinal abdominal surgery. 2. Research center: Multicenter research 3. Research design: A randomized controlled study method would be used in this study, in which the investigators would provi...

The SUMAMOS EXCELENCIA Project: Assessment of Implementation of Best Practices in a National Health System

There is a gap between research and clinical practice, leading to variability in decision-making. Clinical audits are an effective strategy for improving implementation of best practices. Quasi-experimental, multicentre, before-and-after. Primary-care and hospital-care units and associated socio-healthcare structures, and the patients attended at both. Implementation of evi...

CDR Investing in Fatherhood Process Study & Evaluation

This study will evaluate the Investing in Fatherhood: New Pathways program of Child Development Resources (CDR), a Healthy Marriage and Responsible Fatherhood (HMRF) grantee. The program will deliver parenting education, relationship skills training, job preparedness and financial planning, and case management support. This research will consist of a descriptive process and...

Motivations, Expectations, and Decision-making of Sickle Cell Patients in Clinical Research

Background: Sickle cell disease is an inherited blood disorder. People with this disease have a problem with their hemoglobin. That is a protein in red blood cells that carries oxygen in the body. Some people with this disease are enrolled in research at NIH. Researchers want to learn more about the thoughts and opinions of those people. This may improve the way researcher...

Probiotics as Adjuvant Therapy in the Treatment of Metastatic Colorectal Cancer

The research will be prospective, randomised, placebo controlled and double-blinded.The research will be carried on with regards to Helsinki Declaration and following the guidelines of Good Clinical Practice.

PROSPR Project 1: Identifying and Tracking Personalized CRC Screening Regimens for Patients in Clinical Settings

The overall goal of the Parkland-UT Southwestern Population-based Research Optimizing Screening through Personalized Regimens (PROSPR) Center is to optimize colon cancer screening through personalized regimens in the integrated safety-net clinical provider network, which serves a large and diverse population of under- and un-insured patients in Dallas. Together, three resea...

Identifying Correlates of Brain Microglial Activation in Neuropsychiatric Syndromes: A Dimensional Approach

The purpose of this research is to determine whether there is more extensive inflammation in the brain of people with clinical evidence of neuropsychiatric syndromes, such as mood disorder, chronic pain syndrome, dementia, traumatic brain injury, or substance abuse. The research will also explore whether there is more inflammation in patients with more neuropsychiatric symp...

Liquid Biopsy Evaluation and Repository Development at Princess Margaret

The objective of this protocol is to develop an institution-wide liquid biopsy protocol that will establish a common process for collecting blood and corresponding archived tumor specimens for future research studies at the University Health Network's Princess Margaret Cancer Centre. Circulating cell-free nucleic acids (cfNA), including cell-free DNA (cfDNA) and cell-free R...

Motivational Encouragement With Networks (MEN) for Healthy Eating Activity Resting Together (HEART) Health Study

The purpose of this research study is to determine if a health coaching intervention that includes exercise, good dietary habits, and good relaxation methods helps overweight men improve health and lose weight. The investigator's hope is to enroll 30 men in this research study.

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