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Clinical Research Organization Research

15:05 EDT 23rd October 2018 | BioPortfolio

An evaluation of the implementation of a parent-led, games-based physical activity intervention: the Active Play at Home quasi-randomized trial.

NCT02058342. Registered 6 February 2014 retrospectively registered.

Cancer Survivorship and Employment: Intersection of Oral Agents, Changing Workforce Dynamics, and Employers' Perspectives.

The ability to continue employment during and following cancer diagnosis and treatment is critical to working-age cancer survivors. Prolonged survival combined with concerns of the financial burden associated with high-cost therapies makes the mitigation of work-related consequences all the more relevant, particularly in light of recent workforce trends and evolving employment dynamics. Research t...

Free Radical, Carbonyl, and Nicotine Levels Produced by Juul Electronic Cigarettes.

Free radicals and carbonyls produced by electronic cigarettes (e-cigs) have the potential to inflict oxidative stress. Recently, Juul e-cigs have risen drastically in popularity; however, there is no data on nicotine and oxidant yields from this new e-cig design.

Quitting Behaviors among Dual Cigarette/E-cigarette Users and Cigarette Smokers Enrolled in the Tobacco User Adult Cohort (TUAC).

We examined quitting behaviors among a cohort of dual users (cigarettes and e-cigarettes) and exclusive cigarette smokers for: 1) cigarette smoking reduction; 2) quit attempts; 3) abstinence from cigarettes; and 4) abstinence from all tobacco products.

Internet Use and Cognitive Functioning in Late Adulthood: Longitudinal Findings from the Survey of Health, Ageing and Retirement in Europe (SHARE).

Research suggests that cognitive functioning is associated with technology use in late life, but longitudinal research in this domain is still sparse. This study explored the reciprocal association between Internet use and cognitive functioning over a 2-year period.

Funding of cardiovascular research in the USA: Robert Califf and Peter Libby - speak about cardiovascular research funding in the United States and what the latest trends are with Mark Nicholls.

A content analysis of hand hygiene materials targeting elementary-age children.

Millions of dollars have been spent on the design and dissemination of educational materials to improve handwashing to prevent infectious diseases. School-age children have been the focus of many of these efforts; yet little is known about the content of these materials. This study uses content analysis to examine the theoretical and motivational trends as well as the communication approach used i...

Secondhand smoke exposure and depressive symptoms in children: a longitudinal study.

We investigated whether secondhand smoke (SHS) exposure is associated with depressive symptoms in a population-based sample of children.

Influence of the keratinized mucosa on the stability of peri-implant tissues and brushing discomfort: a 4-year follow-up study.

The purpose of the present prospective follow-up study was to evaluate the long-term influence of the peri-implant keratinized mucosa (KM) on marginal bone level (MBL), peri-implant tissues health and brushing discomfort.

Accuracy of flapless immediate implant placement in anterior maxilla using computer-assisted versus freehand surgery: a cadaver study.

To compare the accuracy of computer-guided surgery and freehand surgery on flapless immediate implant placement (IIP) in the anterior maxilla.

Role of fibroblast growth factor 21 in gestational diabetes mellitus: A mini-review.

Gestational diabetes mellitus (GDM) is defined as glucose intolerance with onset or first diagnosis during pregnancy, but not to the level of being diagnostic for diabetes in a non-pregnant adult. In GDM whole-body insulin-dependent glucose disposal decreases by 40-60% which necessitates a 200-250% increase in insulin secretion to maintain normoglycemia. GDM develops when a pregnant woman does not...

Leisure Time and Transportation Walking among Adults With and Without Arthritis- United States, 2010.

Walking is a joint-friendly activity for adults with arthritis.

Toward Rationally Designing Surface Structures of Micro- and Nanocrystallites: Role of Supersaturation.

Tailoring the surface structures of nanocrystals is an exciting research area on account of appealing surface-dependent properties in various applications. Although significant progress has been made in recent years, current synthetic approaches are mainly dependent upon trial and error because of the ambiguous roles of various influencing factors in complicated environments. Therefore, a general ...

Light-Controlled Lipid Interaction and Membrane Organization in Photolipid Bilayer Vesicles.

Controlling lateral interactions between lipid molecules in a bilayer membrane to guide membrane organization and domain formation is a key factor for studying and emulating membrane functionality in synthetic biological systems. Here, we demonstrate an approach to reversibly control lipid organization, domain formation, and membrane stiffness of phospholipid bilayer membranes using the photoswitc...

HST-MRM-MS: A Novel High-Sample-Throughput Multiple Reaction Monitoring Mass Spectrometric Method for Multiplex Absolute Quantitation of Hepatocellular Carcinoma Serum Biomarker.

Absolute quantification of clinical biomarkers by mass spectrometry (MS) has been challenged due to low sample-throughput of current multiple reaction monitoring (MRM) methods. To overcome this problem, in this work, a novel high-sample-throughput multiple reaction monitoring mass spectrometric (HST-MRM-MS) quantification approach is developed to achieve simultaneous quantification of 24 samples. ...

Global Identification of Post-Translationally Spliced Peptides with Neo-Fusion.

Post-translationally spliced peptides have recently garnered significant interest as potential targets for cancer immunotherapy and as contributors to autoimmune diseases such as type 1 diabetes, yet feasible identification methods for spliced peptides have yet to be developed. We present Neo-Fusion, a search program for discovering spliced peptides in tandem mass spectrometry data. Neo-Fusion uti...

Vitamin D supplementation and clinical outcomes in cancer survivorship.

Increasing evidence points to the role of vitamin D supplementation in cancer management. A comprehensive search of online databases was undertaken for all research studies relating to vitamin D supplementation in cancer survivorship published up to November 2017. Eighteen studies meeting the inclusion criteria were selected for this review, the majority of which involved supplementation in breast...

Status of research, regulations and challenges for genetically modified crops in India.

A large number of genetically modified (GM) crops, including both food and non-food crops carrying novel traits have been developed and released for commercial agriculture production. Soybean, maize, canola and cotton for the traits insect resistance and herbicide tolerance are the main crops under commercial cultivation worldwide. In addition, many other GM crops are under development and not yet...

A "Concept," More Than 30 Editions, and a Half-Century of Effort! - An Interview With Dr. Charles B. (Chuck) Corbin.

Trauma-informed care with women diagnosed with postpartum depression: a conceptual framework.

Postpartum depression (PPD) is a mental health disorder that affects approximately 20% of all new mothers. PPD frequently co-occurs with and is exacerbated by trauma, particularly for women from vulnerable populations. Trauma-informed care (TIC) is a best practice that recognizes the importance of, and takes steps to promote recovery from, trauma while preventing retraumatization. Despite its pote...

MAD2 Combined with Mitotic Spindle Apparatus (MSA) and Anticentromere Antibody (ACA) for Diagnosis of Small Cell Lung Cancer (SCLC).

BACKGROUND MAD2 is the gene controlling mitosis. Many studies have assessed MAD2 in various types of carcinoma. Antinuclear mitotic spindle apparatus antibody (MSA) and anticentromere antibody (ACA) are related mitotic antibodies, playing roles in autoimmune diseases and carcinomas, but the expression of MAD2, MSA, and ACA in SCLC is unclear. MATERIAL AND METHODS We enrolled 70 SCLC patients, 72 n...

Decentered Crowdfunded Clinical Studies-Open a New Era of Medical Research.

The Role of Narratives in the Development of Stuttering as a Problem.

Narratives are how people make sense of experiences and give meaning to their lives (Bruner, 1990). Use of narrative therapy (White, 2007) with people who stutter to facilitate the development of preferred stories (as opposed to problem-based stories) has been documented in the literature (Logan, 2013; Ryan, O'Dwyer, & Leahy, 2015). The purpose of this research was to explore the role of narrative...

The Impact of Stuttering on Development of Self-Identity, Relationships, and Quality of Life in Women Who Stutter.

The experiences of women who stutter have been underresearched. Clinicians have little guidance from the research literature on issues specific to women who stutter and are likely to have less clinical contact with this group than with men who stutter because of the higher prevalence of stuttering in men. This study explored the experiences of a small group of women who stutter with a particular f...

Physical activity across adulthood and bone health in later life: the 1946 British birth cohort.

Leisure time physical activity (LTPA) is widely recommended for the prevention of osteoporosis and fractures in older populations. However, whether the beneficial effects of LTPA on bone accumulate across life and are maintained even after reduction or cessation of regular PA in later life is unknown. We aimed to examine whether LTPA across adulthood was cumulatively associated with volumetric and...

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