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Clincial Trials Research

00:30 EST 18th January 2019 | BioPortfolio

Molecular and translational advances in meningiomas.

Meningiomas are the most common primary intracranial neoplasm. The current World Health Organization (WHO) classification categorizes meningiomas based on histopathological features, but emerging molecular data demonstrate the importance of genomic and epigenomic factors in the clinical behavior of these tumors. Treatment options for symptomatic meningiomas are limited to surgical resection where ...

Nanohydroxyapatite exerts cytotoxic effects and prevents cellular proliferation and migration in glioma cells.

Hydroxyapatite (Ca10(PO4)6(OH)2; HAP) is an essential component of the human bone inorganic phase. At the nanoscale level, nanoHAP (nHAP) presents marked emergent properties differing substantially from those of the bulk counterpart. Interestingly, these properties depend on nanoparticle characteristics. In this study, we investigated the cytotoxicity of rod-shaped crystalline nHAP (10- 20 nm x ...

Vitamin D supplementation increases adipokine concentrations in overweight or obese adults.

Vitamin D regulates adipokine production in vitro; however, clinical trials have been inconclusive. We conducted secondary analyses of a randomized controlled trial to examine whether vitamin D supplementation improves adipokine concentrations in overweight/obese and vitamin D-deficient adults.

The effect of omega-3 fatty acids on clinical and paraclinical features of intractable epileptic patients: a triple blind randomized clinical trial.

Long chain omega-3 fatty acids (omega-3 FAs) supplements have been shown to exert beneficial effects in patients with epilepsy through elevation of seizure thresholds and dampening of inflammatory responses. In this triple blind randomized, placebo-controlled parallel group trial of omega-3 FA supplementation, 180 mg eicosapentaenoic acid (EPA) and 120 mg docosahexaenoic acid (DHA) as well as pl...

Library Preparation Using FFPE-Derived Tumor DNA for High-Throughput Hybridization-Based Targeted or Exome Sequencing.

The use of next generation sequencing (NGS) to profile tumor genomes for the presence of diagnostic, prognostic, or therapeutically targetable variants is revolutionizing the practice of oncology and is increasingly utilized in clinical laboratory settings. Beginning with the isolation of DNA of sufficient quality and quantity from a tumor specimen, the creation of a library of genomic fragments r...

Safety and Tolerability of c-MET Inhibitors in Cancer.

The role of aberrant hepatocyte growth factor receptor (c-MET, also known as tyrosine-protein kinase MET)/hepatocyte growth factor (HGF) signaling in cancer progression and invasion has been extensively studied. c-MET inhibitors have shown promising pre-clinical and early phase clinical trial anti-tumor activity in several tumor types, although results of most phase III trials with these agents ha...

Evaluation of Antibody Properties and Clinically Relevant Immunogenicity, Anaphylaxis, and Hypersensitivity Reactions in Two Phase III Trials of Tralokinumab in Severe, Uncontrolled Asthma.

Tralokinumab is a monoclonal antibody (mAb) that neutralizes interleukin (IL)-13, a cytokine involved in the pathogenesis of asthma.

Highly Ambient-Stable 1T-MoS and 1T-WS by Hydrothermal Synthesis under High Magnetic Fields.

Phase-controlled synthesis of metallic and ambient-stable two-dimensional MX (M is Mo or W, and X is S) with 1T octahedral coordination will endow these materials with superior performance as compared to their semiconducting 2H coordination counterparts. Here, we report a clean and facile route to prepare 1T-MoS and 1T-WS through hydrothermal processing under high magnetic fields. We reveal that t...

Proton and Deuterium NMR study of the CBC9CB Dimer System.

Using proton and deuterium NMR spectroscopy, this work provides a description of the molecular orientational order of the mesogenic groups in both Ntb and the classical nematic phase (N), of the liquid crystal dimer CB-C9-CB. The proton NMR data were collected at high eld (7 Tesla) with the nematic domains aligned by the eld. Deuterium NMR data obtained from aligned samples at 11.7 Tesla, publishe...

Drop Behavior Influenced by the Correlation Length on Noisy Surfaces.

We investigate numerically the role of the correlation length in drop behavior on noisy surfaces. To this aim, a phase field tool has been used. Theoretical results are confirmed by experiments of distilled water drops sitting on stainless steel and silicon surfaces textured by laser-induced periodic self-organized structures: an increase of the noise amplitude results in an amplification of the o...

Faster oxygen uptake, heart rate and ventilatory kinetics in Stepping compared to Cycle ergometry in COPD patients during moderate intensity exercise.

Although step tests are a stressful and feasible cost-effective modality to evaluate aerobic performance, the eccentric in addition to concentric muscle contractions of the legs on stepping emerge as a potential speeding factor for cardioventilatory and metabolic adjustments towards a steady-state, since eccentric contractions would prompt an earlier and stronger mechanoreceptor activation, beside...

Enhancing Parenting Quality for Young Children Adopted Internationally: Results of a Randomized Controlled Trial.

Children adopted internationally are often dysregulated biologically and behaviorally due to prior experiences of institutional care or caregiving changes and thus are in need of enhanced parental care. The present study assessed whether parents randomized to receive Attachment and Biobehavioral Catch-up (ABC) demonstrated significant improvements in parenting quality when compared to parents rece...

Investigational luteinizing hormone releasing hormone (LHRH) agonists and other hormonal agents in early stage clinical trials for prostate cancer.

The treatment and management of prostate cancer continues to evolve; newer classes of agents and combination therapies are being developed and some are being investigated in early phase clinical trials. Areas covered: We discuss investigational hormonal agents for the treatment of prostate cancer and focus primarily on luteinizing hormone releasing hormone (LHRH) agonists in early stage trials. We...

Hypercapnic acidosis induces mitochondrial dysfunction and impairs the ability of mesenchymal stem cells to promote distal lung epithelial repair.

Acute respiratory distress syndrome (ARDS) is a devastating disorder characterized by diffuse inflammation and edema formation. The main management strategy, low tidal volume ventilation, can be associated with the development of hypercapnic acidosis (HCA). Mesenchymal stem cells (MSCs) are a promising therapeutic candidate currently in early-phase clinical trials. The effects of HCA on the alveol...

Chronic kidney disease predicts atrial fibrillation in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention.

Atrial fibrillation (AF) often complicates ST-segment elevation myocardial infarction (STEMI). Predictors of AF in this setting include factors related to the acute phase of STEMI and pre-existing conditions. More recently, novel AF predictors have been identified in the general population. We aimed to assess the ability of such novel factors to predict STEMI-related AF.

Validation and quantification of neonicotinoid insecticide residues in rice whole grain and rice straw using LC-MS/MS.

An efficient analytical method was developed and validated using a modified QuEChERS method and LC-MS/MS for the detection and quantification of neonicotinoid insecticide residues in rice whole grain and rice straw. The samples were extracted using acetonitrile and cleaned up by dispersive solid-phase extraction. Validation based on five fortification levels showed good recoveries of neonicotinoid...

Rapid detection of internalizing diagnosis in young children enabled by wearable sensors and machine learning.

There is a critical need for fast, inexpensive, objective, and accurate screening tools for childhood psychopathology. Perhaps most compelling is in the case of internalizing disorders, like anxiety and depression, where unobservable symptoms cause children to go unassessed-suffering in silence because they never exhibiting the disruptive behaviors that would lead to a referral for diagnostic asse...

Early short-term PXT3003 combinational therapy delays disease onset in a transgenic rat model of Charcot-Marie-Tooth disease 1A (CMT1A).

The most common type of Charcot-Marie-Tooth disease is caused by a duplication of PMP22 leading to dysmyelination, axonal loss and progressive muscle weakness (CMT1A). Currently, no approved therapy is available for CMT1A patients. A novel polytherapeutic proof-of-principle approach using PXT3003, a low-dose combination of baclofen, naltrexone and sorbitol, slowed disease progression after long-te...

Therapeutic Fc fusion protein misfolding: A three-phasic cultivation experimental design.

Cell culture process optimization is a critical solution to most of the challenges faced by the pharmaceutical manufacturing. One of the major problems encountered in large-scale production of therapeutic proteins is misfolded protein production. The accumulation of misfolded therapeutic proteins is an immunogenic signal and a risk factor for immunogenicity of the final product. The aim of this st...

BA08: An open-label, single-arm, non-randomised, phase 2 trial of cisplatin, methotrexate and vinblastine (CMV) for pure squamous cell cancer of the urinary tract.

Pure squamous cell carcinoma (SCC) of the urinary tract is rare in the UK and has a poor prognosis compared with transitional cell carcinoma (TCC). Cisplatin based chemotherapy has been shown to be effective in TCC.

Effect of induction therapy with lenalidomide, doxorubicin, and dexamethasone on bone remodeling and angiogenesis in newly diagnosed multiple myeloma.

There is limited data regarding the efficacy and safety of lenalidomide, adriamycin and dexamethasone (RAD) combination on newly diagnosed multiple myeloma (NDMM) patients. There is also scarce information about the effect of lenalidomide on bone metabolism and angiogenesis in NDMM. Thus, we conducted a phase 2 study to evaluate the efficacy and safety of RAD regimen as induction in transplant-eli...

Exploring the potential for rosacea therapeutics of siRNA dispersion in topical emulsions.

Rosacea is a prevalent skin condition dependent on the individual genetic profile. The current pharmacological management of this condition is mostly based on small molecule drugs predominately effective in ameliorating the inflammatory condition. Emerging molecular approaches could present an opportunity for managing rosacea conditions at transcriptomic level, and in the future allow personalized...

The Visualization of Interfacially PdHx Fertilized Intermetallic PdZn in Pd/ZnO Catalyst.

Controllable synthesis of the well-defined supported intermetallic catalysts is highly demanded due to their unique properties in physical chemistry. To accurately pinpoint their evolution at atomic-scale, particularly the clarification of the initial state under chemical environment, contributes to rational design and optimal synthesis of catalysts. Herein we unravel a dynamic formation in a ZnO ...

Hydralazine derivative of aldehyde: A new type of M-H ion formed in electrospray ionization mass spectrometry.

Hydralazine has been widely employed in the development of drugs, derivatization reagents and ligands. In the present work, we reported a new type of dehydrogenated ion [M-H] that was produced from the hydralazine derivative of hexanal in electrospray ionization mass spectrometry (ESI-MS). The formation of [M-H] ions in the ESI-MS was found to be independent on the mobile phase composition of the ...

Nylon intermediates from bio-based levulinic acid.

Use of ZrO2/SiO2 as solid acid catalyst in the ring-opening of bio-based γ-valerolactone with methanol in the gas phase leads to mixtures of methyl 2-, 3- and 4-pentenoate (MP) in over 95% selectivity, containing a surprising 81% of M4P. This allows the application of a selective hydroformylation of this mixture in which M4P is converted into methyl 5-formyl-valerate (M5FV) with 90% selectivity a...

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