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Clincial Trials Research

23:13 EDT 21st July 2018 | BioPortfolio

Optimizing regulatory T cells for therapeutic application in human organ transplantation.

Initial clinical trials of adoptive regulatory T-cell (Treg) therapy in solid organ transplantation have proven to be both feasible and well tolerated. With Phase 2 trials underway, efforts have been focused on the optimization of the Treg product.

Bracing Following Transforaminal Lumbar Interbody Fusion is not Necessary for Patients With Degenerative Lumbar Spine Disease: A Prospective, Randomized Trial.

This is a prospective, randomized trial.

Elevated Expression of Transforming Acidic Coiled-Coil Containing Protein 3 (TACC3) Is Associated With a Poor Prognosis in Osteosarcoma.

Transforming acidic coiled-coil containing protein 3 (TACC3) is expressed during the mitotic phase of nuclear division and regulates microtubules. Recently, high TACC3 expression in tumor cells of various cancers including soft tissue sarcoma has been reported. However, its role in osteosarcoma remains unknown. Because we have few prognostic markers for survival in osteosarcoma, we wanted to inves...

CORR Insights®: No Clinically Important Difference in Pain Scores After THA Between Periarticular Analgesic Injection and Placebo: A Randomized Trial.

Gemstone spectral imaging in lung cancer: A preliminary study.

The present study aimed to evaluate the application of gemstone spectral imaging (GSI) for multi-parameter quantitative measurement in lung cancer.The study retrospectively enrolled 30 patients with lung cancer who underwent chest contrast enhanced CT scan with GSI mode. The GSI viewer was used for image display and data analysis. Optimal energy value, CT values at 40 keV, 70 keV and optimal energ...

Thermodynamics of SrNiMoO and SrCoMoO and their stability under reducing conditions.

The values of standard enthalpy of formation at 298.15 K and 1 atm for the double perovskites Sr2NiMoO6 and Sr2CoMoO6, measured by means of drop solution calorimetry, were found to be -2418.1 ± 12.4 and -2422.9 ± 9.6 kJ mol-1, respectively. Heat capacity of Sr2NiMoO6 and Sr2CoMoO6 was measured between 2 and 370 K using relaxation and adiabatic calorimetry, and the enthalpy increments - between 3...

CT quantitative analysis study for angiogenesis, and degree of ischemic necrosis and glucose metabolite in non-small cell lung cancer.

We aimed at exploring the feasibility of noninvasive late arterial phase enhanced CT imaging in evaluating tumor angiogenesis, ischemic necrosis, and glucose metabolism, thereby providing pathological information for the comprehensive treatment plan in non-small cell lung cancer (NSCLC).

The feasibility and acceptability of a novel anxiety in bipolar disorder intervention compared to treatment as usual: A randomized controlled trial.

Comorbid anxiety is common in bipolar disorder (BD) and associated with worse clinical outcomes including increased suicidality. Despite effective psychological treatments for anxiety, research into treating anxiety in BD is underdeveloped. This paper describes a novel psychological intervention to address anxiety in context of bipolar disorder (AIBD).

Ice-Liquid Oscillations in Nanoconfined Water.

Nanoscale confinement has a strong effect on the phase behavior of water. Studies of the last two decades have revealed a wealth of novel crystalline and quasicrystalline structures for water confined in nanoslits. Less is known, however, about the nature of ice-liquid coexistence in extremely nanoconfined systems. Here we use molecular simulations to investigate the ice-liquid equilibrium for wat...

In silico screening of Metal-Organic Frameworks for adsorption driven heat pumps and chillers.

A computational screening of 2930 experimentally synthesized Metal-Organic Frame- works (MOFs) is carried out to find the best performing structures for adsorption driven cooling (AC) applications with methanol and ethanol as working fluids. The screening methodology consists of 4 subsequent screening steps for each adsorbate. At the end of each step the most promising MOFs for AC application are ...

Electrospray Ionization of Polypropylene Glycol: Rayleigh-Charged Droplets, Competing Pathways, and Charge State-Dependent Conformations.

Recent molecular dynamics (MD) simulations from various laboratories have advanced the general understanding of electrospray ionization (ESI)-related processes. Unfortunately, computational cost has limited most of those previous endeavors to ESI droplets with radii of ~3 nm or less, which represent the low end of the size distribution in the ESI plume. The current work extends this range by condu...

Highly-Selective Optoelectronic Nose Based on Surface Plasmon Resonance Imaging for Sensing Volatile Organic Compounds.

Monitoring volatile organic compounds (VOCs) is an important issue, but difficult to achieve on a large scale and on the field using conventional analytical methods. Electronic noses (eNs), as promising alternatives, are still compromised by their per-formances due to the fact that most of them rely on a very limited number of sensors and use databases devoid of kinetic in-formation. To narrow the...

MnOx/IrOx as selective oxygen evolution electrocatalyst in acidic chloride solution.

The oxygen evolution reaction (OER) and chlorine evolution reaction (CER) are electrochemical processes with high relevance to water splitting for (solar) energy conversion and industrial production of commodity chemicals, respectively. Carrying out the two reactions separately is challenging, since the catalytic intermediates are linked by scaling relations. Optimizing the efficiency of OER over ...

Limiting feeding to the active phase reduces blood pressure without the necessity of caloric reduction or fat mass loss.

Reducing body weight has been shown to lower blood pressure in obesity-related hypertension. However, success of those lifestyle interventions is limited due to poor long-term compliance. Emerging evidence indicate that feeding schedule plays a role on the regulation of blood pressure. With two studies, we examined the role of feeding schedule on energy homeostasis and blood pressure. In Study 1, ...

CPX-351 (cytarabine and daunorubicin) Liposome for Injection Versus Conventional Cytarabine Plus Daunorubicin in Older Patients With Newly Diagnosed Secondary Acute Myeloid Leukemia.

Purpose CPX-351 is a dual-drug liposomal encapsulation of cytarabine and daunorubicin that delivers a synergistic 5:1 drug ratio into leukemia cells to a greater extent than normal bone marrow cells. Prior clinical studies demonstrated a sustained drug ratio and exposure in vivo and prolonged survival versus standard-of-care cytarabine plus daunorubicin chemotherapy (7+3 regimen) in older patients...

To switch or not to switch: Intentions to switch to injectable PrEP among gay and bisexual men with at least twelve months oral PrEP experience.

Phase III trials of long-acting injectable (LAI) PrEP, currently underway, have great potential for expanding the menu of HIV prevention options. Imagining a future in which multiple PrEP modalities are available to potential users of biomedical HIV prevention, we investigated which factors might help direct a patient-physician shared-decision making process to optimize the choice of biomedical HI...

Modeling the role of microRNA-449a in the regulation of the G2/M cell cycle checkpoint in prostate LNCaP cells under ionizing radiation.

Recent studies showed that induced microRNA-449a (miR-449a) enhances a G2/M cell cycle checkpoint arrest in prostate cancer (LNCaP) and lung adenocarcinoma cell lines. In the case of LNCaP cells, upregulated miR-449a directly downregulates c-Myc that is required to induce the cell cycle regulators Cdc25A and Cdc2/CyclinB whose inactivation blocks G2 to M phase transition. However, the molecular me...

Evaluation of Microbial Contamination in the Inner Surface of Titanium Implants Before Healing Abutment Connection: A Prospective Clinical Trial.

The objective of this investigation was to assess the microbiologic contamination in the inner surface of titanium implants prior to prosthetic abutment placement.

Bone Volume Dynamics and Implant Placement Torque in Horizontal Bone Defects Reconstructed with Autologous or Xenogeneic Block Bone: A Randomized, Controlled, Split-Mouth, Prospective Clinical Trial.

The aim of this study was to evaluate volumetric stability of autologous and xenogeneic block grafts and primary stability of implants in maxillary grafted areas.

A Cross-Sectional and Longitudinal Study of Retinal Sensitivity in RPE65-Associated Leber Congenital Amaurosis.

RPE65-associated Leber congenital amaurosis (RPE65-LCA) is an early-onset severe retinal dystrophy associated with progressive visual field loss. Phase I/II and III gene therapy trials have identified improved retinal sensitivity but little is known about the natural history of retinal sensitivity in RPE65-LCA.

A Clinical Trial with Combined Transcranial Direct Current Stimulation and Attentional Bias Modification in Alcohol Dependent Patients.

Modifying attentional processes with attentional bias modification (ABM) might be a relevant add-on to treatment in addiction. This study investigated whether influencing cortical plasticity with transcranial direct current stimulation (tDCS) could increase training effects. TDCS could also help alcohol-dependent patients to overcome craving and reduce relapse, independent of training. These appro...

Simultaneous electrokinetic and hydrodynamic injection (SEHI) and sequential stacking featuring sweeping for signal amplification following MEKC during the analysis of rapamycin (sirolimus) in serum samples.

Simultaneous electrokinetic and hydrodynamic injection (SEHI) of rapamycin (sirolimus) with off-line and on-line sample pre-concentration techniques and using micellar electrokinetic chromatography (MEKC) has been studied. Compared to conventional hydrodynamic injection, a 168-fold improvement in the signal was obtained with a combination of SEHI and field enhanced sample injection (FESI) in conju...

One-dimensional Arsenic Allotropes: Polymerization of Yellow Arsenic Inside Single-wall Carbon Nanotubes.

The pnictogen nanomaterials, including phosphorene and arsenene, display remarkable electronic and chemical properties. Yet, the structural diversity that these main group elements are capable of is still poorly explored. Here we fill single-wall carbon nanotubes with elemental arsenic from the vapor phase. Using electron microscopy, we find chains of highly reactive As₄ molecules as well as two...

Isolated collagen mimetic peptide assemblies have stable triple-helix structures.

The origin of the triple-helix structure and high stability of collagen has been debated for many years. As models of the triple helix and building blocks for new biomaterials, collagen mimetic peptide (CMP) assemblies have been deeply studied in the condensed phase. In particular, it was found that hydroxylation of proline, an abundant post-translational modification in collagen, increases its st...

Clinical outcomes of adolescents and young adults with advanced solid tumours participating in phase I trials.

Adolescent and young adult (AYA) patients with advanced solid tumours are often considered for phase I clinical trials with novel agents. The outcome of AYAs in these trials have not been described before.

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