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Compliance Research

04:21 EDT 17th October 2018 | BioPortfolio

Emotion regulation, conflict resolution, and spillover on subsequent family functioning.

How does emotion regulation in one social context spillover to functioning in another? We investigate this novel question by drawing upon recent evidence that 3 categories underpin the most commonly assessed emotion regulation strategies: disengagement, aversive cognitive perseveration, and adaptive engagement. We examine how these emotion regulation categories during marital conflict are associat...

Emotion Reactivity and Regulation in Adolescent Girls Following an Interpersonal Rejection.

Failures in emotion regulation, especially as a result of interpersonal stress, are implicated as transdiagnostic risk factors for psychopathology. This study examines the effects of an experimentally timed targeted interpersonal rejection on emotion reactivity and regulation in typically developing adolescent girls. Girls ( N = 33, ages 9-16 years, M = 12.47, SD = 2.20) underwent fMRI involving a...

Bone morphogenetic protein 2 increases lysyl oxidase activity via up-regulation of snail in human granulosa-lutein cells.

Lysyl oxidase (LOX) is a copper-dependent enzyme that maintains and stabilizes the extracellular matrix (ECM) by catalyzing the cross-linking of elastin and collagen. ECM within the ovarian follicle plays a crucial role in regulating follicular development and oocyte maturation. Bone morphogenetic protein 2 (BMP2) belongs to the BMP subfamily that has been shown to be involved in the process of ov...

Ethical Issues Pertaining to Conflicts of Interest Between Neurologists and the Pharmaceutical and Medical Device Industries.

A conflict of interest (COI) exists when a physician's professional responsibilities are compromised by personal or financial relationships. COIs between physicians and the pharmaceutical or medical device industry (Industry) are common. Collaborations with Industry have many potential benefits, but also raise potential ethical pitfalls. Industry-related COIs have widespread influence on medical e...

Introduction to special editorial on statistical guidance for a successful research paper.

Modulation of alternative splicing of trafficking genes by genome editing reveals functional consequences in muscle biology.

Alternative splicing is a regulatory mechanism by which multiple mRNA isoforms are generated from single genes. Numerous genes that encode membrane trafficking proteins are alternatively spliced. However, there is limited information about the functional consequences that result from these splicing transitions. Here, we developed appropriate tools to study the functional impact of alternative spli...

Regulation of ATM and ATR by SMARCAL1 and BRG1.

The G2/M checkpoint is activated on DNA damage by the ATM and ATR kinases that are regulated by post-translational modifications. In this paper, the transcriptional co-regulation of ATM and ATR by SMARCAL1 and BRG1, both members of the ATP-dependent chromatin remodeling protein family, is described. SMARCAL1 and BRG1 co-localize on the promoters of ATM and ATR; downregulation of SMARCAL1 and BRG1 ...

Thermochromism-induced temperature self-regulation and alternating photothermal nanohelix clusters for synergistic tumor chemo/photothermal therapy.

To improve the inherent defects of chemotherapy and photothermal therapy (PTT), we design a novel thermochromism-induced temperature self-regulation and alternating photothermal system based on iodine (I)-loaded acetylated amylose nanohelix clusters (ILAA NHCs) under the guidance of molecular dynamic simulation in which I is loaded into the helical cavity of acetylated amylose (AA) by hydrophobic ...

Netrin Signaling Defines the Regional Border in the Drosophila Visual Center.

The brain consists of distinct domains defined by sharp borders. So far, the mechanisms of compartmentalization of developing tissues include cell adhesion, cell repulsion, and cortical tension. These mechanisms are tightly related to molecular machineries at the cell membrane. However, we and others demonstrated that Slit, a chemorepellent, is required to establish the borders in the fly brain. H...

Posttranscriptional and posttranslational regulation of actin.

Actin is one of the most abundant intracellular proteins, essential in every eukaryotic cell type. Actin plays key roles in tissue morphogenesis, cell adhesion, muscle contraction, and developmental reprogramming. Most actin studies have focused on its regulation at the protein level, either directly or through differential interactions with over a hundred intracellular binding partners. However, ...

Interoceptive awareness in attention deficit hyperactivity disorder.

ADHD is considered a disorder of self-regulation. Recent research has shown that awareness of bodily states, referred to as interoceptive awareness, crucially contributes to self-regulatory processes. Impaired self-regulation in ADHD has been explained in terms of arousal regulation deficits in ADHD (the state regulation deficit (SRD) account). There is now ample support for the SRD account, howev...

Fibroblast growth factor 23 is associated with fractional excretion of sodium in patients with chronic kidney disease.

Recent studies suggest that the phosphaturic hormone fibroblast growth factor 23 (FGF23) is involved in regulation of renal sodium excretion and blood pressure. There is evidence of both direct effects via regulation of the sodium-chloride symporter (NCC) in the distal tubule, and indirect effects through interactions with the renin-angiotensin-aldosterone system. However, clinical data on the ass...

mRNA cap regulation in mammalian cell function and fate.

In this review we explore the regulation of mRNA cap formation and its impact on mammalian cells. The mRNA cap is a highly methylated modification of the 5' end of RNA pol II-transcribed RNA. It protects RNA from degradation, recruits complexes involved in RNA processing, export and translation initiation, and marks cellular mRNA as "self" to avoid recognition by the innate immune system. The mRNA...

Dorsal Scapular Neuropathy as a Rare Cause of Complex Regional Pain Syndrome: A Reappraisal on Ultrasound Imaging and Guidance for Recalcitrant Pain.

Real-World Experience of Palbociclib-Induced Adverse Events and Compliance With Complete Blood Count Monitoring in Women With Hormone Receptor-Positive/HER2-Negative Metastatic Breast Cancer.

The cyclin-dependent kinase 4/6 inhibitor palbociclib has emerged as a novel therapeutic agent in metastatic breast cancer. Neutropenia is commonly observed, and thus stringent treatment guidelines regarding complete blood count (CBC) monitoring have been developed. The aim of this study was to provide a real-world experience of the toxicities associated with palbociclib therapy and to evaluate co...

Successful erector spinae plane block without ultrasound guidance in a severely cardiovascular compromised patient.

Integration of Stress Signaling in Through Cell Non-autonomous Contributions of the JNK Homolog KGB-1.

Dealing with physiological stress is a necessity for all organisms, and the pathways charged with this task are highly conserved in metazoa. Accumulating evidence highlights cell non-autonomous activation as an important mode of integrating stress responses at the organism level, and work in further highlighted the importance of such regulation for the unfolded protein response (UPR) and for DAF-...

Challenges of enforcing cell phone use while driving laws among police: a qualitative study.

Cell phone use while driving laws do not appear to be heavily enforced in the USA. This study seeks to gain law enforcements' perspective and learn potential barriers to cell phone law enforcement.

Heated tobacco product regulation under US law and the FCTC.

Tobacco companies are marketing new 'heated tobacco products' (HTPs) composed of battery-powered holders, chargers and tobacco plugs or sticks. The non-tobacco HTP components have escaped effective regulation under many countries' tobacco control laws because they are packaged and sold separately from the tobacco-containing components. In the USA, HTPs cannot be marketed unless the Food and Drug A...

Impact of FAAH genetic variation on fronto-amygdala function during emotional processing.

Recent translational studies identified a common endocannabinoid polymorphism, FAAH C385A, in the gene for the fatty acid amide hydrolase (FAAH). This polymorphism alters endocannabinoid anandamide levels, which are known to be involved in the fronto-amygdala circuitry implicated in mood regulation and anxiety-like behaviors. While it has been shown that the variant that selectively enhances front...

A multicomponent approach toward understanding emotion regulation in schizophrenia.

Emotion deficits are well documented in people with schizophrenia. Far less is known about their ability to implement emotion regulation strategies. We sought to explore whether people with schizophrenia can modify their emotion responses similar to controls.

Swimmers' Compliance to Training as a Function of Observation: A Pilot Study.

Adherence to prescribed training intensity (i.e., swim speed) has been conveyed as a key parameter regarding improvements in seasonal performance. Evidence has also suggested swimmers have difficulty complying with coach-prescribed training. How this compliance is affected by a coaching presence and oversight has yet to be examined.

Zika virus and sexual transmission: updated preconception guidance.

In situ Gluten-Chitosan Interlocked Self-Assembled Supramolecular Architecture Reduces T-Cell-Mediated Immune Response to Gluten in Celiac Disease.

The prevalence of celiac disease has increased since the last half of the 20th century and is now about 1% in most western populations. At present, people who suffer from celiac disease have to follow a gluten-exclusion diet throughout their lives. Compliance to this restrictive diet is demanding and the development of alternative strategies has become urgent.

Opioid and cocaine use among primary care patients on buprenorphine-Self-report and urine drug tests.

Urine drug tests (UDTs) are recommended to monitor patients treated for opioid use disorder in primary care. The aims are to (1) estimate the frequency of self-report and UDT results of opioid and cocaine use and (2) evaluate the association between treatment time with non-disclosure of opioid or cocaine use and having a positive UDT.

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