Compliance Research

10:23 EST 11th December 2017 | BioPortfolio

Nanoscale Tuning of VCAM-1 Determines VLA-4-dependent Melanoma Cell Plasticity on RGD Motifs.

The biophysical fine-tuning of cancer cell plasticity is crucial for tumor progression but remains largely enigmatic. Although Vascular Cell Adhesion Molecule-1 (VCAM-1/CD106) has been implicated in melanoma progression, here its presentation on endothelial cells was associated with diminished melanoma cell spreading. Using a specific nanoscale-modulation of VCAM-1 (tunable from 70 to 670 ligands...

Mandatory helmet legislation as a policy tool for reducing motorcycle fatalities: Pinpointing the efficacy of universal helmet laws.

This study uses repeated cross-sections of individual level crash data to study the effectiveness of motorcycle helmet legislation. Results suggest that motorcycle helmet laws reduce average individual fatality risks by 20.5%. From a policy standpoint, large states such as Florida and Texas can reduce annual motorcycle fatalities by an average 100 deaths through reinstating universal helmet laws. ...

Features of Pharmaceutical Compounding in the Republic of Tajikistan.

Despite the deep assortment of finished pharmaceutical products and the reduction in the number of compounding and hospital pharmacies in the Republic of Tajikistan, the need for extemporal medicinal products is still preserved and remains relevant. This article discusses the practice of compounding in the Republic of Tajikistan. History, laws, limits, regulatory institutions, protocols for compou...

FERONIA/FER-like Receptor Kinases Integrate and Modulate Multiple Signaling Pathways in Fruit Development and Ripening.

Ripening of fleshy fruits is a complex process that involves dramatic changes in color, texture, flavor, and aroma, which is essentially regulated by multiple hormone signals. Although the metabolic mechanisms for the regulation of fruit development and ripening have been studied extensively, little is known about the signaling mechanisms underlying this process. FERONIA has been increasingly sugg...

CircLRP6 regulation of ZEB1 via miR-455 is involved in the epithelial-mesenchymal transition during arsenite-induced malignant transformation of human keratinocytes.

Circular RNAs (circRNAs), a class of noncoding RNAs generated from pre-mRNAs, participate in the regulation of tumorigenesis. The mechanism for regulation, however, is unclear. Here, to determine if circular RNAs are involved in arsenite-induced epithelial-mesenchymal transition (EMT) and malignant transformation in human keratinocyte (HaCaT) cells, the up-regulation of circLRP6 was confirmed in a...

Homeostatic Scaling of AMPA Receptors by Semaphorin.

Regulation of AMPA receptors mediates homeostatic scaling. In this issue of Neuron, Wang et al. (2017) identify a new role of secreted semaphorin 3F and elucidate how it triggers synaptic downscaling of AMPA receptors through regulation of the binding of Sema3F holoreceptor complex to AMPA receptors.

The impact of new national guidance for the public health management of enteric fever in England.

New guidance was published in England in February 2012 to support the public health management of enteric fever and reduce the risks of secondary transmission. The new guidance was evaluated to assess: STUDY DESIGN: Quantitative and qualitative evaluation of the implementation of new public health guidance.

Compliance with Postpartum Diabetes Screening Recommendations for Patients with Gestational Diabetes.

The role of provider type and level of training have not been examined in regard to impact on postpartum testing for patients with gestational diabetes mellitus (GDM).

Testing the mindfulness-to-meaning theory: Evidence for mindful positive emotion regulation from a reanalysis of longitudinal data.

The Mindfulness to Meaning Theory (MMT) provides a detailed process model of mindful positive emotion regulation.

Corrigendum: Systematic reviews: guidance relevant for studies of older people.

Comprehensive Characterization of the Complex lola Locus Reveals a Novel Role in the Octopaminergic Pathway via Tyramine Beta-Hydroxylase Regulation.

Longitudinals lacking (lola) is one of the most complex genes in Drosophila melanogaster, encoding up to 20 protein isoforms that include key transcription factors involved in axonal pathfinding and neural reprogramming. Most previous studies have employed loss-of-function alleles that disrupt lola common exons, making it difficult to delineate isoform-specific functions. To overcome this issue, w...

Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive.

Humans have been fascinated by sleep for millennia. After almost a century of scientific interrogation, significant progress has been made in understanding the neuronal regulation and functions of sleep. The application of new methods in neuroscience that enable the analysis of genetically defined neuronal circuits with unprecedented specificity and precision has been paramount in this endeavor. I...

Analysis of the Strength of Legal Firearms Restrictions for Perpetrators of Domestic Violence and Their Association With Intimate Partner Homicide.

In this research, we estimate the association of firearm restrictions for domestic violence offenders with intimate partner homicides (IPHs), based on the strength of the policies. We posit that the association of firearm laws with IPHs depends on the laws': 1) breadth of coverage of high-risk individuals and situations restricted; 2) power to compel firearm surrender or removal from prohibited pe...

circlncRNAnet: An integrated web-based resource for mapping functional networks of long or circular forms of non-coding RNAs.

Despite their lack of protein-coding potential, lncRNAs and circRNAs have emerged as key determinants in gene regulation, acting to fine-tune transcriptional and signaling output. These non-coding RNA transcripts are known to affect expression of messenger RNAs (mRNAs) via epigenetic and post-transcriptional regulation. Given their widespread target spectrum as well as extensive modes of action, a...

Phytochromes: Where to Start?

Phytochrome signaling allows plants to sense and respond to light through gene regulation. Ushijima et al. (2017) demonstrate a role for phytochromes in widespread regulation of alternative promoter usage, resulting in light-dependent protein isoforms with altered subcellular localization that help the plant respond metabolically to fluctuating light conditions.

Stick-Slip Instabilities for Interfacial Chemical Bond-Induced Friction at the Nanoscale.

Earthquakes are generally caused by unstable stick-slip motion of rocks at faults. This stick-slip phenomenon, along with other frictional properties of materials at the macroscale, are well-described by empirical rate and state friction (RSF) laws. Here we show stick-slip behavior for nanoscale single-asperity silica-silica contacts. The stick-slip is quasi-periodic, and both the amplitude and sp...

Evaluating UK National Guidance for Screening of Children for TB: A Prospective Multi-centre Study.

Rationale and Objective In order to identify infected contacts of tuberculosis (TB) cases, the UK National Institute for Health and Care Excellence (NICE) recommended the addition of interferon-gamma release assays (IGRA) to the tuberculin skin test (TST) in its 2006 TB guidelines. Treatment for TB infection was no longer recommended for children screened TST-positive but IGRA-negative. We carried...

Genipin-treated chitosan nanofibers as a novel scaffold for nerve guidance channel design.

Schwann cell-seeded nerve guidance channels are designed to assist post-traumatic nerve regeneration in the PNS. Chitosan is a natural polymer well suited for tissue engineering as it is biocompatible, non-immunogenic, and biodegradable. Electrospun chitosan nanofibers utilized in nerve guidance channels have the capacity for guiding axonal growth within the channel lumen yet are limited in their ...

Methylmercury complexes: Selection of thermodynamic properties and application to the modelling of a column experiment.

Complexation with methyl groups produces the most toxic form of mercury, especially because of its capacity to bioconcentrate in living tissues. Understanding and integrating methylation and demethylation processes is of the utmost interest in providing geochemical models relevant for environmental assessment. In a first step, we investigated methylation at equilibrium, by selecting the thermodyna...

Multimedia Aided Consent for Alzheimer's Disease Research.

Optimizing the research consent process simultaneously fosters respect for autonomy and protection of those with diminished capacity for autonomy. This study evaluated the effectiveness of an enhanced research consent procedure, employing multimedia disclosure and corrective feedback, in improving decisional capacity among 114 people with mild-to-moderate Alzheimer's disease (AD) and 134 non-psych...

The identification of at-risk patients and prevention of venous thromboembolism in pediatric cancer: guidance from the SSC of the ISTH.

HIV serostatus knowledge and serostatus disclosure with the most recent anal intercourse partner in a European MSM sample recruited in 13 cities: results from the Sialon-II study.

Knowledge of HIV status can be important in reducing the risk of HIV exposure. In a European sample of men-who-have-sex-with-men (MSM), we aimed to identify factors associated with HIV serostatus disclosure to the most recent anal intercourse (AI) partner. We also aimed to describe the impact of HIV serostatus disclosure on HIV exposure risks.

Smart toothbrush will provide real time guidance to patients.

Exposure to Parental Depression in Adolescence and Risk for Metabolic Syndrome in Adulthood.

The psychosocial consequences of living with a depressed parent have been well characterized. Less well known, however, is how this exposure is predictive of later physical health problems. The present study evaluated how parental depression across youths' adolescence (ages 11-18) was associated with youth metabolic syndrome at age 25 (n = 391). Youth self-regulation and health behaviors were co...

Reproductive Autonomy and Regulation-Coexistence in Action.

On occasion, British in vitro fertilization practitioners look over the ocean to the practice of IVF and embryo research in the United States, wonder why these areas are subject to less regulation than in the United Kingdom, and ask how much less risky and more progressive IVF and embryo research might be if subject to additional federal, or at least state, regulation. To an American audience, imb...

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