Constipation Research

23:15 EST 17th January 2019 | BioPortfolio

Benefit-Risk Assessment of Plecanatide in the Treatment of Chronic Idiopathic Constipation.

Plecanatide, a uroguanylin analog, activates the guanylate cyclase C receptors in the epithelial lining of the gastrointestinal tract in a pH-dependent fashion initiating (1) the conversion of intracellular guanosine triphosphate to cyclic guanosine monophosphate, which increases the activity of the cystic fibrosis transmembrane conductance regulator to increase chloride and bicarbonate secretion ...

Current State of Neuromodulation for Constipation and Fecal Incontinence in Children: A Systematic Review.

 Neuromodulation is the application of electrical stimulation on nerve fibers to modulate the neuronal activity. Its use for chronic constipation and fecal incontinence has increased in popularity over the past few years. Invasive and noninvasive techniques are currently available. We reviewed the current literature on the application of the neuromodulation techniques in the management of chroni...

Pain inhibition by opioids-new concepts.

Opioids are the oldest and most potent drugs for the treatment of severe pain but they are burdened by detrimental side effects, such as respiratory depression, addiction potential, sedation, nausea and constipation. Their clinical application is undisputed in the treatment of acute (e.g. perioperative) and cancer pain but their long-term use in chronic pain has met increasing criticism and has co...

Dilemma of the giant abdominal cyst.

Giant abdominal cyst can lead to various non-specific symptoms such as abdominal bloating, nausea/vomiting, constipation due to its mass effect. In rarer circumstances, it can lead to bowel obstruction, hydronephrosis and even abdominal compartment syndrome. Hereby, we present a case of giant abdominal cyst in a young woman where its origin was a diagnostic dilemma despite exhausting all imaging t...

A review of the effect of faecal incontinence and constipation on sexual function.

Faecal incontinence and constipation are common conditions which may adversely affect quality of life. They may have an adverse effect on sexual function.

The role of oxycodone/naloxone in the management of patients with pain and opioid-induced constipation.

Common opioid adverse effects (AE) of the gastrointestinal tract include opioid-induced constipation (OIC) and opioid-induced bowel dysfunction (OIBD) with traditional laxatives being of limited efficacy, having AEs and not addressing the pathophysiology of OIC or OIBD. Targeted treatment comprises of PAMORA (peripherally acting mu-opioid receptor antagonists) and a combination of an opioid recept...

Dietary exclusion of fructose and lactose after positive breath tests improved rapid-transit constipation in children.

Exclusion of ermentable ligosaccharides, isaccharides, onosaccharides, and olyols (FODMAPs) from the diet is effective in alleviating symptoms of irritable bowel syndrome (IBS) in adults. Rapid-transit constipation (RTC) is a recently discovered subset of chronic constipation and has been linked to food intolerance. The aim of this study was to audit the effect of specific FODMAP elimination diets...

Concurrent total abdominal colectomy and ileorectal anastomosis with transvaginal posterior colporrhaphy for constipation.

MRI analysis of fecal volume and dryness: Validation study using an experimental oxycodone-induced constipation model.

Opioids are known to affect gastrointestinal motility, but their effect on fluid absorption and secretion is poorly understood in humans.

The effect of glucomannan on pregnancy constipation.

Constipation is a common complication among pregnant women; it refers to hard and infrequent bowel movements where the stools defected from body becomes hard and dry, as well. various medical interventions are nowadays implemented to treat constipation, Some of which are either banned or not willingly implemented by pregnant women; thus, doctors try to avoid such methods. Glucomannan, a combinatio...

Efficiency of diet change in irritable bowel syndrome.

Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by symptoms of abdominal pain, bloating, and altered bowel habit such as constipation, diarrhea, or both. Food is one of the most commonly reported triggers of IBS symptoms. we aim to assess the effect of diet change in improving IBS.

Peripherally Acting Mu-Opioid Antagonist for the Treatment of Opioid-Induced Constipation: Systematic Review and Meta-Analysis.

Opioid-induced constipation (OIC) is a frequent adverse event (AE) that impairs patients' quality of life (QOL). Peripherally acting mu-opioid receptor antagonists (PAMORAs) have been recognized as a treatment option for OIC but the effect consistent across the studies has not been evaluated.

Constipation in nocturnal enuresis may interfere desmopressin management success.

Previous studies indicated that the prevalence of constipation in enuretic patients is higher than that in the general population. Several studies have revealed that successful treatment of constipation may be helpful in resolving enuresis. However, constipation affecting the efficacy of desmopressin in treating enuresis remains to be clarified.

Lactulose for the treatment of Chinese children with chronic constipation: A randomized controlled trial.

This study aimed to investigate the efficacy and safety of lactulose for the treatment of Chinese children with chronic constipation.

Use of botulinum toxin in Parkinson's disease.

Botulinum toxin has emerged as an important therapeutic intervention within the realm of movement disorders, especially for focal and generalized dystonias. Botulinum toxin has additionally been used for a variety of symptoms associated with parkinsonism. In this review, we will specifically evaluate use of botulinum toxin in idiopathic Parkinson's disease. We will discuss symptoms including sialo...

Constipation in a cohort prospective in adult critically ill patients: How much occurs and why?

To assess the incidence and factors associated with constipation in adult critical care patients.

Oceanobacillus timonensis sp. nov. and Oceanobacillus senegalensis sp. nov., two new moderately halophilic, Gram-stain positive bacteria isolated from stools sample of healthy young Senegalese.

Oceanobacillus timonensis Marseille-P3532 (CSUR P3532, CCUG 70981) and Oceanobacillus senegalensis Marseille-P3587 (CSUR P3587, CCUG 70613), are the type strains of O. timonensis sp. nov. and O. senegalensis sp. nov., respectively. They are moderately halophilic, aerobic, motile and Gram-stain positive bacteria. The strains P3532 and P3587 were isolated from stools with 3.8% and 2.1% sodium chlori...

Plecanatide for Treatment of Chronic Constipation and Irritable Bowel Syndrome.

Chronic idiopathic constipation and irritable bowel syndrome with constipation are commonly encountered in ambulatory patients, but limited options exist for patients with persistent or severe symptoms following treatment with non-prescription products. Plecanatide (Trulance, Synergy Pharmaceuticals) is a 16-amino acid peptide analogue of uroguanylin that stimulates guanylate cyclase-C receptors t...

Macrogol (polyethylene glycol) 4000 without electrolytes in the symptomatic treatment of chronic constipation: a profile of its use.

Macrogol 4000, a biologically inert, non-absorbable osmotic laxative, is a highly effective and well-tolerated first-line option for the treatment of the symptoms of chronic idiopathic/functional constipation in children and adults. High-molecular-weight (HMW) macrogols ± electrolytes have generally similar efficacy profiles; however, the taste of macrogol 4000 is generally preferred over tha...

Prevalence of functional constipation among Palestinian preschool children and the relation to stressful life events.

Increasing evidence exists with respect to the relation between stressful life events and functional constipation (FC). We aimed to investigate the prevalence of FC in Palestinian refugee preschool children and to determine if stress and trauma exposure are risk factors of FC in these children.

Genus Psoralea A review of the traditional and modern uses, phytochemistry and pharmacology.

The genus Psoralea (Fabaceae) harbours 105 accepted species that are extensively used by local peoples and medicinal practitioners of China, India, and other countries for treatment of tooth decay, psoriasis, leucoderma, leprosy, kidney problems, tuberculosis, indigestion, constipation and impotence. Presently, pharmacological research reports are available on only few species namely Bituminaria b...

Role of guar fiber in improving digestive health and function.

Digestive health plays key role in our active daily life; but maintaining proper bowel movements, i.e., being free from constipation, diarrhea, irritable bowel syndrome, inflammatory bowel disease, flatulence, bloating, and abdominal pain, is complex. Dietary fibers often are recommended to maintain proper digestive health, but none seems to provide a single comprehensive solution for overall main...

Gut-Directed Pelvic Floor Behavioral Treatment for Fecal Incontinence and Constipation in Patients with Inflammatory Bowel Disease.

Patients with inflammatory bowel disease (IBD) often experience functional bowel symptoms despite achieving disease remission. Although behavioral treatment (bowel and pelvic floor muscle retraining) is effective for managing constipation or fecal incontinence in non-IBD patients, there is limited evidence for its efficacy in patients with quiescent inflammatory bowel disease. The aim of this stud...

Chronic constipation in a migrant from Paraguay.

Spicatoside A in red Liriope platyphylla displays a laxative effect in a constipation rat model via regulating mAChRs and ER stress signaling.

Red Liriope platyphylla extract (EtRLP) has been used as an oriental medicine for treatment of several chronic conditions, such as neurodegenerative disorders, diabetes, and obesity. To investigate the laxative activity of EtRLP, the levels of key constipation markers and their molecular regulators were examined following administration of EtRLP in constipation Sprague Dawley (SD) rats treated wi...

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