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Corneal Conditions Research

08:32 EDT 15th October 2018 | BioPortfolio

Systematic investigation of the deformation mechanisms of a γ-TiAl single crystal.

We propose a theoretical framework to predict the deformation mechanism of the γ-TiAl single crystal without lattice defects by combining the generalized stacking fault energy and the Schmid factor. Our theory is validated against an excellent testbed, the single crystal nanowire, by correctly predicting four major deformation mechanisms, namely, ordinary slip, super slip, twinning, and mixed sli...

Corneal densitometry as predictive diagnostic tool for visual acuity results following Descemet membrane endothelial keratoplasty.

To investigate correlations between preoperative corneal backscatter with visual acuity results following Descemet Membrane Endothelial Keratoplasty (DMEK) in eyes with corneal endothelial disorders.

Optical Lattice with Torus Topology.

We propose an experimental scheme to construct an optical lattice where the atoms are confined to the surface of a torus. This construction can be realized with spatially shaped laser beams which could be realized with recently developed high resolution imaging techniques. We numerically study the feasibility of this proposal by calculating the tunneling strengths for atoms in the torus lattice. T...

Assessing the Effects of Ripasudil, a Novel Rho Kinase Inhibitor, on Human Corneal Endothelial Cell Health.

To determine how the Rho kinase inhibitor, ripasudil, affects metabolic function and cell viability in donor human corneal endothelial cells (HCECs).

Determinants of Corneal Endothelial Cell Loss After Trabeculectomy with Mitomycin C.

To investigate factors associated with decreased corneal endothelial cell density (ECD) after trabeculectomy with mitomycin C (MMC).

Xanthine oxidase is hyper-active in Duchenne muscular dystrophy.

Generation of superoxide by xanthine oxidase can be stimulated under ischemic and aberrant calcium homeostasis. Because patients and mice with Duchenne muscular dystrophy (DMD) suffer from ischemia and excessive calcium influx, we tested the hypothesis that xanthine oxidase activity is elevated and contributes to disease pathology. Xanthine oxidase activity was measured by urinary isoxanthopterin ...

The 2016 ENFSI Fingerprint Working Group testing programme.

In 2016, the Fingerprint Working Group (EFP-WG) of the European Network of Forensic Science Institutes (ENFSI), officially established an advisory group with the task of organising proficiency tests (PTs), as well as collaborative exercises (CEs) as a way of raising standards within the fingerprint profession. This article will provide an overview of the Visualisation collaborative exercise and th...

Immune Response and Mechanisms of IFN-γ in Administration for Keratomycosis.

To investigate the immune response and mechanisms of interferon-γ (IFN-γ) in the fungal keratitis in mice.

Laboratory Results, Epidemiological Features, and Outcome Analyses of Microbial Keratitis: A 15-Year Review from Saint Louis.

To evaluate the laboratory results and prognostic factors of poor clinical outcomes in microbial keratitis cases over 15 years at Saint Louis University.

A collagen film with micro-rough surface can promote the corneal epithelization process for corneal repair.

Corneal disease is a major cause of blindness and keratoplasty is an effective treatment method. A freeze-dried collagen film (FD-Col) with micro-rough surface structure for corneal epithelial repair was reported in our previous studies. In this research, we conducted a more comprehensive study on the FD-Col film. Besides with excellent mechanical property and optical transparency, the FD-Col film...

Descemet's Membrane Biomimetic Microtopography Differentiates Human Mesenchymal Stem Cells Into Corneal Endothelial-Like Cells.

Loss of corneal endothelial cells (CECs) bears disastrous consequences for the patient, including corneal clouding and blindness. Corneal transplantation is currently the only therapy for severe corneal disorders. However, the worldwide shortages of corneal donor material generate a strong demand for personalized stem cell-based alternative therapies. Because human mesenchymal stem cells are known...

ADULT-ONSET VITELLIFORM MACULAR DYSTROPHY SECONDARY TO A NOVEL IMPG2 GENE VARIANT.

To report a case of adult-onset vitelliform macular dystrophy in a patient who was found to have a previously unreported variant of the IMPG2 gene.

Managing normal tension glaucoma by lowering the intraocular pressure.

Normal tension glaucoma (NTG) is a diagnosis assigned when characteristic glaucomatous structural and functional optic nerve defects are present in the setting of intraocular pressures (IOP) measurements below 21 mm Hg. Spot IOP measurements are generally obtained in the office during business hours and often determine who is classified as having "normal",pressures. Reduction of IOP has been the c...

Potentiality of microemulsion systems in treatment of ophthalmic disorders: Keratoconus and dry eye syndrome - In vivo study.

Microemulsions are widely studied as potential ocular drug delivery vehicles. In the present study we show the versatility of possible use microemulsions as ocular delivery vehicle. The ME is loaded with a hydrophilic drug, riboflavin phosphate (RFP) and a lipophilic, docosahexaenoic acid in triglyceride form (TG-DHA), each separately. These drugs treat keratoconus and dry eye syndrome, respective...

Anomalous Phonon Lifetime Shortening in Paramagnetic CrN Caused by Spin-Lattice Coupling: A Combined Spin and Ab Initio Molecular Dynamics Study.

We study the mutual coupling of spin fluctuations and lattice vibrations in paramagnetic CrN by combining atomistic spin dynamics and ab initio molecular dynamics. The two degrees of freedom are dynamically coupled, leading to nonadiabatic effects. Those effects suppress the phonon lifetimes at low temperature compared to an adiabatic approach. The dynamic coupling identified here provides an exp...

Differences in Posterior Corneal Features Between Normal Corneas and Subclinical Keratoconus.

To compare posterior corneal features and their discriminating power for differentiating normal corneas from subclinical keratoconus using the Placido dual-Scheimpflug analyzer.

Sequential Customized Therapeutic Keratectomy for Reis-Bücklers' Corneal Dystrophy: Long-term Follow-up.

To report long-term outcomes of sequential customized therapeutic keratectomy for Reis-Bücklers' corneal dystrophy.

Outcomes of Simultaneous and Sequential Cross-linking With Excimer Laser Surface Ablation in Keratoconus.

To evaluate the outcomes of simultaneous and sequential corneal crosslinking (CXL) and excimer laser surface ablation protocols in keratoconus.

Characterization of virulence factors, antimicrobial resistance patterns and biofilm formation of Pseudomonas aeruginosa and Staphylococcus spp. strains isolated from corneal infection.

Infectious keratitis is a serious ocular infection that can lead to severe visual impairment and blindness. Bacterial pathogens are responsible for nearly half of infectious keratitis cases. This study was performed to determine the virulence factors, antimicrobial resistance patterns, and biofilm formation ability of Pseudomonas aeruginosa and Staphylococcus spp. strains isolated from corneal inf...

Cryopreservation of human umbilical vein and porcine corneal endothelial cell monolayers.

Cryopreservation of endothelium is one of the major challenges in the cryopreservation of complex tissues. Human umbilical vein endothelial cells (HUVECs) in suspension are available commercially and recently their post-thaw cell membrane integrity was significantly improved by cryopreservation in 5% dimethyl sulfoxide (MeSO) and 6% hydroxyethyl starch (HES). However, cryopreservation of cells in ...

Intraocular pressure and wound state immediately after long versus short clear corneal incision cataract surgery.

To compare the intraocular pressure (IOP) and wound state immediately after cataract surgery for eyes with a long clear corneal incision (CCI) with those for eyes with a short CCI.

Novel ultra-small micelles based on rebaudioside A: A potential nanoplatform for ocular drug delivery.

We investigated if the self-assembled micelles of rebaudioside A (RA) could potentially be utilized as an ocular drug-delivery system in this investigation. RA self-assembled into micelles with ultra-small particle sizes (< 4 nm) in a homogeneous distribution state (polydispersity index < 0.3). RA had good cellular tolerance and no cytotoxicity was observed at concentrations ≤ 18.5 mg/ml at 72 h...

Influence of distortions of recorded diffraction patterns on strain analysis by nano-beam electron diffraction.

Images acquired in transmission electron microscopes can be distorted for various reasons such as e.g. aberrations of the lenses of the imaging system or inaccuracies of the image recording system. This results in inaccuracies of measures obtained from the distorted images. Here we report on measurement and correction of elliptical distortions of diffraction patterns. The effect of this correction...

Dusp6 is a genetic modifier of growth through enhanced ERK activity.

Like other single gene disorders, muscular dystrophy displays a range of phenotypic heterogeneity even with the same primary mutation. Identifying genetic modifiers capable of altering the course of muscular dystrophy is one approach to deciphering gene-gene interactions that can be exploited for therapy development. To this end, we used an intercross strategy in mice to map modifiers of muscular ...

Basan gets a new fingerprint: Mutations in the skin-specific isoform of SMARCAD1 cause ectodermal dysplasia syndromes with adermatoglyphia.

Basan syndrome is an autosomal dominant ectodermal dysplasia (ED) with congenital adermatoglyphia, transient neonatal acral bullae, and congenital facial milia. Autosomal dominant adermatoglyphia (ADG) is characterized as adermatoglyphia with hypohidrosis. Recently mutations in the skin-specific isoform of the gene SMARCAD1 have been found in both syndromes. This report proposes to unify these two...

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