endpoint Company Profile

00:15 EST 24th November 2017 | BioPortfolio

Endpoint provides clients with high-quality, authoritative advice on the clinical development of medicines. Endpoint's clients include multinational pharmaceutical companies, emerging biomedical ventures, biotechnology investment firms, contract research organizations, regulatory agencies and national health services.
Endpoint was started in London by Kenneth Klein, MD, a Harvard-trained physician who is board-certified in both internal medicine and gastroenterology. After a career in academic medicine Dr. Klein worked for 15 years in the pharmaceutical industry, holding various management positions with companies in the United States and Europe. He has helped bring major products from Phase I through regulatory approval and marketing. For example, for four years he was Global Project Leader for the anti-migraine drug zolmitriptan, now marketed as Zomig. In this position he led all aspects of the drug's worldwide development. This included primary responsibility for the design and implementation of the clinical trial program and coordination of the basic science, manufacturing, regulatory and commercial strategies.



News Articles [204 Associated News Articles listed on BioPortfolio]

Novartis Showcases 4 Potential Blockbusters in Its Late-Stage Pipeline

RTH258 demonstrates superiority versus aflibercept in key secondary endpoint measures of disease activity and meets primary endpoint of non-inferiority in patients with nAMD.

Eli Lilly & Co. Says Its Migraine Drug Met Primary Endpoint In Late-stage Trial

Eli Lilly & Co. said early Friday that its migraine drug lasmiditan met its primary endpoint and a key secondary endpoint in a late-stage clinical trial.

[Articles] 24-month intervention with a specific multinutrient in people with prodromal Alzheimer's disease (LipiDiDiet): a randomised, double-blind, controlled trial

The intervention had no significant effect on the NTB primary endpoint over 2 years in prodromal Alzheimer's disease. However, cognitive decline in this population was much lower than expected, render...

Eli Lilly: Lasmiditan Meets Primary Endpoint In Second Phase 3 Study

INDIANAPOLIS (dpa-AFX) - Eli Lilly and Company (LLY) announced that lasmiditan, an investigational molecule for the acute treatment of migraine, met its primary endpoint in SPARTAN, a second Phase...

Janssen: Phase III study of single-tablet, daily HIV-1 treatment achieves endpoint

The primary endpoint of Janssen Pharmaceuticals' Phase III AMBER clinical trial was achieved, showing that its daily single-t -More- 

The Role of Clinical Endpoint Committees in Medical Device Trials, a New Webinar Presented by ...

TORONTO, ON--(Marketwired - August 18, 2017) -This webinar will discuss the value of clinical endpoint committees in medical device evaluation programs and explore Read more...

Roche and AbbVie's leukaemia combo smashes Phase 3 endpoint

Venclexta/Venclyxto (venetoclax), Roche and AbbVie’s oral B-cell lymphoma-2 (BCL-2) inhibitor, successfully met its primary endpoint in Phase 3 trials, providing prolonged, progression-free survival...

Cytokinetics’ ALS treatment tirasemtiv fails to meet primary endpoint in phase 3 study

Cytokinetics has announced that international phase 3 clinical trial of tirasemtiv in patients with amyotrophic lateral sclerosis (ALS) has did not meet the primary endpoint.

Drugs and Medications [38 Associated Drugs and Medications listed on BioPortfolio]

Perindopril erbumine [Aurobindo Pharma Limited]

These highlights do not include all the information needed to use perindopril erbumine safely and effectively. See full prescribing information for perindopril erbumine tablets.Perindopril Erbumine Ta...

Losartan potassium [Qualitest Pharmaceuticals]


Losartan potassium [Endo Pharmaceuticals Inc. DBA Endo Generic Products]

Losartan Potassium Tablets USP R only

Leflunomide [NorthStar RxLLC]

Leflunomide Tablets USP

Renagel [Genzyme Corporation]

These highlights do not include all the information needed to use Renagel safely and effectively. See full prescribing information for Renagel. Renagel (sevelamer hydrochloride) Tablet for Oral use In...

PubMed Articles [115 Associated PubMed Articles listed on BioPortfolio]

Statistical considerations in the choice of endpoint for drug use disorder trials.

To date, the US Food and Drug Administration (FDA) requires drug use disorder trials developing new medications to use abstinence, a clinically meaningful endpoint, as the primary outcome. Although ab...

Lipid correlates of antidepressant response to omega-3 polyunsaturated fatty acid supplementation: A pilot study.

Low omega-3 polyunsaturated fatty acid (PUFA) levels are seen in major depression. We examined effects of six weeks of fish oil supplementation on clinical characteristics in 16 patients with symptoma...

Biomarkers-A General Review.

A biomarker is a biological observation that substitutes for and ideally predicts a clinically relevant endpoint or intermediate outcome that is more difficult to observe. The use of clinical biomarke...

A duplex endpoint PCR assay for rapid detection and differentiation of Leptospira strains.

This study aimed to develop a duplex endpoint PCR assay for rapid detection and differentiation of Leptospira strains.

Clinical Trial Principles and Endpoint Definitions for Paravalvular Leaks in Surgical Prosthesis: An Expert Statement.

The VARC (Valve Academic Research Consortium) for transcatheter aortic valve replacement set the standard for selecting appropriate clinical endpoints reflecting safety and effectiveness of transcathe...

Clinical Trials [937 Associated Clinical Trials listed on BioPortfolio]

A Clinical Trial Comparing Efficacy and Safety of Dabigatran Etexilate With Warfarin in Patients With Cerebral Venous and Dural Sinus Thrombosis (RE-SPECT CVT)

This is a multi-center, prospective, international, randomized (1:1), open-label study with two parallel groups. This phase III study is planned to investigate the efficacy and safety of d...

Risk Accessment Model for Ischemic Stroke Endpoint Events

The present study aims to develope a risk accessment model of ischemic stroke endpoint events combining multi-dimensional TCM indicators with modern medicine indicators. The proposed study...

The WEB®-IT China Clinical Study

This trial is a prospective, multicenter, single-arm Objective Performance Criteria controlled confirmatory study. It is for evaluating safety and effectiveness of the WEB Aneurysm Emboliz...

Ablation vs Drug Therapy for Atrial Fibrillation - Pilot Trial

CABANA is designed to test the hypothesis that the treatment strategy of percutaneous left atrial catheter ablation for the purpose of the elimination of atrial fibrillation (AF) is superi...

Study of Olmesartan Medoxomil (CS-866) in Patients With Chronic Glomerulonephritis or Diabetic Nephropathy

The treatment period was 16 weeks, the initial dose, 5 mg, was unforcedly titrated to 10 mg, 20 mg and 40 mg after confirming tolerance at weeks 4, 8 and 12. The primary endpoint for effic...

Companies [23 Associated Companies listed on BioPortfolio]

EndPoint Technologies

EndPoint Technologies is dedicated to providing comprehensive technology and business consulting services to life science organizations. Specializing in Medical Affairs in pharmac...

Endpoint Research

Endpoint Research is a full service Clinical Research Organization founded in 1990. We provide Phase I/II to IV clinical development services to pharmaceutical, biotechnology and medical device compan...


IGEL delivers powerful unified endpoint management (UEM) software that is revolutionary in its simplicity and purpose-built for the enterprise. The company’s world-leading pr...


Valentis is a biotechnology company that was engaged in the development of innovative products for peripheral arterial disease (PAD), a large and unsatisfied market. On July 11, 2006 Valentis announce...


Endpoint provides clients with high-quality, authoritative advice on the clinical development of medicines. Endpoint's clients include multinational pharmaceutical companies, emerging biomedical ventu...

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