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Intradigm Corporation Company Profile

09:28 EDT 22nd September 2018 | BioPortfolio

Intradigm is developing siRNA-derived cancer therapeutics utilizing its proprietary RNAi technology. Intradigm has led the advancement of siRNA from the test tube to a potent, tissue-targeted, systemically active therapeutic class of gene specific inhibitors. The Company believes that it is the first to demonstrate consistent and reproducible siRNA activity in animal disease models through targeted formulations of siRNA for systemic administration. Based upon the Company’s unique technology and capabilities for developing systemic tissue targeted formulations of siRNA and its ability to achieve efficacy in clinically relevant animal disease models, Intradigm has established an impressive cancer therapeutic product development program with its lead product, ICS-283, now in advanced pre-clinical development.
The Company’s initial focus is on siRNA inhibition of the VEGF pathway targeted to the angiogenic neovasculature. The siRNA formulated product can be used for the treatment of many serious diseases that result from excessive and unwanted angiogenesis, such as colon cancer, lung cancer and many other solid tumors as well as other angiogenesis based diseases such as ocular neovascularization. Intradigm has utilized its proprietary TargeTranÔ technology to develop siRNA formulations which can be systemically delivered and specifically targeted to neovasculature. This targeted, specific sequence siRNA, utilizing innovative layered nanoparticle technology, has been successfully evaluated in several angiogenesis disease animal models with demonstrated efficacy. Intradigm has identified colon cancer as the first indication to evaluate for its systemically administered VEGF pathway siRNA and expects to file an IND within the next 12 months.

In addition to its therapeutic product focus, Intradigm has taken advantage of its portfolio of in vivo siRNA technologies to establish a target validation service business to

Location

12115 Parklawn Drive, Suite K
Rockville
Maryland
20852,
United States of America

Contact

Phone: (301)984-0185
Fax: (301)984-0186 (301)984-0186
Email: info@intradigm.com


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