Privately held Biocept was founded in 1997 and is based in Carlsbad, California near San Diego.
Biocept is emerging as a leader in the development and commercialization, in part through partners, of Next Generation Microarrays for Genomics and Proteomicsâ„¢. Bioceptâ€™s proprietary platform technology is based on novel hydrogel polymers. The resulting three-dimensional microarrays have very high sensitivity, excellent precision and a broad dynamic range. Biocept has already developed several assay formats for the analysis of samples containing nucleic acids or proteins. Biocept has collaborations with investigators at leading research organizations for prototype microarrays to monitor the expression of apoptosis-related genes.
Life Sciences applications of Bioceptâ€™s genomic and proteomic microarrays include pharmaceutical research and development [e.g. target identification and validation, expression profiling, pathway analysis, high throughput screening, ADMET studies, and detection of single nucleotide polymorphisms (SNP's)] and clinical diagnostics.
Science & Technology:
Successful genomic and proteomic research requires tools that can rapidly and accurately provide results. While gene expression profiling is frequently the first step, protein expression may ultimately be more important, since proteins are the targets for most drugs. Gene expression does not always correlate well with the amount or activity of expressed proteins. In addition, protein diversity and activity results from alternative splicing at the messenger RNA level and by post-translational modifications such as phosphorylation and glycosylation. Several forms of a single protein may have important roles either as targets for drug discovery or as indicators of toxicity. These relationships demonstrate the crucial importance of proteomics in drug discovery.
Biocept's platform technology uses proprietary hydrogel polymers to create three-dimensional microarrays. Biocept prints microdroplets in an array on a treated glass slide. Each microdroplet contains a large number of molecules of a single probe, uniformly dispersed within and covalently bound to the hydrogel matrix. Key features of Biocept's microarrays are:
Â§ Versatile-useful for genomic and proteomic applications-
Biocept has developed and demonstrated the utility of genomic and proteomic microarrays in formats suitable for many life sciences applications.
Â§ High probe density provides high precision and broad dynamic range-
The higher probe density provides a lower coefficient of variation and broader dynamic range than conventional two-dimensional microarrays.
Â· Aqueous environment allows biomolecular probes to retain native conformation and activity-
Probes tethered within a hydrogel microdroplet retain their native three-dimensional configuration and activity, improving interaction with targets in the sample.
Â§ Readily manufactured-
Microdroplets about 300 microns in diameter and 30 microns thick are deposited as an array on a treated glass slide.
Bioceptâ€™s platform technology is protected by issued or pending patents in all major pharmaceutical markets.
Biocept is establishing corporate partnerships and other collaborations to accelerate the development, commercialization and utilization of microarrays based on its technology. This includes partnerships with Pharmaceutical/Biotech companies for research and development, collaborations with Life Science Reagents companies, partnerships for clinical diagnostics, and partnerships to enhance technology development and commercialization.
2151 Las Palmas Drive, Suite C Carlsbad CA 92009 United States of America
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Bioinformatics Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...
Assays An assay is an analytic procedure for qualitatively assessing or quantitatively measuring the presence or amount or the functional activity of a target entity. This can be a drug or biochemical substance or a cell in an organism or organic sample.