Cell Signalling Technology Incorporated Company Profile

11:12 EDT 20th March 2018 | BioPortfolio

CST offers a broad array of new reagents to assist in the discovery of how proteins are regulated and function within the cell. These cutting edge tools are designed to advance the understanding of Protein Function, and to open up new research directions in Neurobiology, Cancer Biology and basic Cell Biology. Scientists at CST have established a leadership position in the market for phospho-antibodies that are useful in detecting activity in discrete pathways that regulate growth and death in cells.


166B Cummings Center
United States of America


Phone: 1 978 921 6216
Fax: 1 978 922 7069

News Articles [1475 Associated News Articles listed on BioPortfolio]

[Comment] Can umbralisib bring PI3Kδ out of the shadows?

During the past 5 years, the treatment landscape for patients with B-cell malignancies has seen a sharp increase in the array of available small molecules that target dysregulated pathways necessary f...

Cell-geometry-dependent changes in plasma membrane order direct stem cell signalling and fate

PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis

T cell non-Hodgkin lymphomas are a heterogeneous group of highly aggressive malignancies with poor clinical outcomes. T cell lymphomas originate from peripheral T cells and are frequently characterize...

Regulation of T cell signalling by membrane lipids

Targeting B cell receptor signalling in cancer: preclinical and clinical advances

Axo-myelinic neurotransmission: a novel mode of cell signalling in the central nervous system

[Comment] Acalabrutinib in mantle cell lymphoma

Mantle cell lymphoma is a rare, distinct subtype of non-Hodgkin lymphoma, with a disparate clinical course that varies from indolent at times to frequently aggressive. No standard of care exists; most...

Researchers Develop Single Cell Level Sorting Technology Using Sound Waves

New cell manipulation technology enables highly accurate isolation of rare cell populations in complex biological samples

PubMed Articles [4202 Associated PubMed Articles listed on BioPortfolio]

Intracrine VEGF signalling mediates colorectal cancer cell migration and invasion.

Vascular endothelial growth factor (VEGF) and its receptors (VEGFRs) are key regulators of angiogenesis, affecting endothelial cell survival and function. However, the effect of VEGF-VEGFR signalling ...

Inhibition of Notch signalling has ability to alter the proximal and distal TCR signalling events in human CD3(+) αβ T-cells.

The Notch signalling pathway is an important regulator of T cell function and is known to regulate the effector functions of T cells driven by T cell receptor (TCR). However, the mechanism integrating...

Signalling for B cell survival.

The number of mature B cells is carefully controlled by signalling from receptors that support B cell survival. The best studied of these are the B cell antigen receptor (BCR) and BAFFR. Recent work h...

Errors in mutagenesis and the benefit of cell-to-cell signalling in the evolution of stress-induced mutagenesis.

Stress-induced mutagenesis is a widely observed phenomenon. Theoretical models have shown that stress-induced mutagenesis can be favoured by natural selection due to the beneficial mutations it genera...

Wnt Signalling in Intestinal Stem Cells: Lessons from Mice and Flies.

Adult stem cells play critical roles in the basal maintenance of tissue integrity, also known as homeostasis, and in tissue regeneration following damage. The highly conserved Wnt signalling pathway i...

Clinical Trials [6963 Associated Clinical Trials listed on BioPortfolio]

A Notch Signalling Pathway Inhibitor for Patients With T-cell Acute Lymphoblastic Leukemia/Lymphoma (ALL)(0752-013)

A Notch signalling pathway inhibitor study in pediatric and adult patients with relapsed (worsening) or refractory (not responding to treatment) T-cell acute lymphoblastic leukemia/lymphom...

Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma

This randomized phase I/II clinical trial is studying the side effects and best dose of gamma-secretase/notch signalling pathway inhibitor RO4929097 when given together with vismodegib and...

Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Recurrent or Progressive Glioblastoma

This phase II clinical trial is studying how well RO4929097 works in treating patients with recurrent or progressive glioblastoma. RO4929097 may stop the growth of tumor cells by blocking ...

Gamma-secretase/Notch Signalling Pathway Inhibitor RO4929097 in Combination With Cisplatin, Vinblastine, and Temozolomide in Treating Patients With Recurrent or Metastatic Melanoma

This phase Ib/II trial studies the side effects and best dose of gamma-secretase/Notch signalling pathway inhibitor RO4929097 when given together with cisplatin, vinblastine, and temozolom...

The Role of GLP-1 Receptor Signalling in the Glucose-lowering Effect of Metformin in Patients With T2D

Delineation of the role of glucagon-like peptide-1 receptor signalling in the glucose-lowering effect of metformin during meal ingestion in patients with type 2 diabetes.

Companies [1557 Associated Companies listed on BioPortfolio]


SUGEN is a biopharmaceutical company focused on the discovery and development of small molecule drugs which target specific cellular signal transduction pathways. These signalling pathw...

Cell Signalling Technology Incorporated

CST offers a broad array of new reagents to assist in the discovery of how proteins are regulated and function within the cell. These cutting edge tools are designed to advance the understanding of Pr...

TGR BioSciences Pty Ltd

TGR BioSciences Pty Ltd (TGR) is a private company located in Adelaide, Australia. Established in 2001, TGR is committed to providing innovative solutions for cell-based research applications. Our s...


PRAECIS PHARMACEUTICALS INCORPORATED is a biopharmaceutical company focused on the discovery and development of novel compounds to address unmet medical needs or improve existing therapies.PRAECIS has...

One Cell Systems, Inc.

One Cell Systems is developing and marketing a family of single cell assays that rely on microencapsulation and flow cytometry. Technology underlying these products has been developed internally and l...

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