Cell Signalling Technology Incorporated Company Profile

16:49 EST 18th November 2017 | BioPortfolio

CST offers a broad array of new reagents to assist in the discovery of how proteins are regulated and function within the cell. These cutting edge tools are designed to advance the understanding of Protein Function, and to open up new research directions in Neurobiology, Cancer Biology and basic Cell Biology. Scientists at CST have established a leadership position in the market for phospho-antibodies that are useful in detecting activity in discrete pathways that regulate growth and death in cells.


166B Cummings Center
United States of America


Phone: 1 978 921 6216
Fax: 1 978 922 7069

News Articles [1571 Associated News Articles listed on BioPortfolio]

Cytoskeletal control of B cell responses to antigens

The actin cytoskeleton of B cells is extensively coupled to B cell receptor (BCR) signalling pathways. This Review summarizes recent evidence that indicates that actin orchestrates BCR signalling at t...

p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection

Dondelinger et al. and Menon et al. show that MAPKAP kinase-2 (MK2) phosphorylates RIPK1 to regulate TNF-mediated cell death as well as RIPK1 signalling in inflammation and bacterial infection.

PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis

T cell non-Hodgkin lymphomas are a heterogeneous group of highly aggressive malignancies with poor clinical outcomes. T cell lymphomas originate from peripheral T cells and are frequently characterize...

Intestinal hypoxia and hypoxia-induced signalling as therapeutic targets for IBD

IBD is associated with markedly reduced intestinal mucosal oxygen levels. In this Review, the authors discuss the role of mucosal hypoxia and hypoxia-induced signalling in IBD and identify potential t...

Cell signalling: Even kinase-inactive BRAF is oncogenic

WNT signalling in prostate cancer

WNT signalling pathway components are potentially important in prostate tumours, particularly in the development of castration-resistant prostate cancer and in the prostate tumour microenvironment. He...

Competing memories of mitogen and p53 signalling control cell-cycle entry

Regulation of cell proliferation is necessary for immune responses, tissue repair, and upkeep of organ function to maintain human health. When proliferating cells complete mitosis, a fraction of newly...

Axo-myelinic neurotransmission: a novel mode of cell signalling in the central nervous system

PubMed Articles [4191 Associated PubMed Articles listed on BioPortfolio]

Hippo signalling in intestinal regeneration and cancer.

The Hippo pathway is a unique signalling module that regulates cell-specific transcriptional responses and responds to a wide range of intrinsic and extrinsic cues. Besides its classical role in restr...

GLP-1 signalling compensates for impaired insulin signalling in regulating beta cell proliferation in βIRKO mice.

We aimed to investigate potential interactions between insulin and glucagon-like peptide (GLP)-1 signalling pathways in the regulation of beta cell-cycle dynamics in vivo, in the context of the therap...

Intracrine VEGF signalling mediates colorectal cancer cell migration and invasion.

Vascular endothelial growth factor (VEGF) and its receptors (VEGFRs) are key regulators of angiogenesis, affecting endothelial cell survival and function. However, the effect of VEGF-VEGFR signalling ...

Inhibition of Notch signalling has ability to alter the proximal and distal TCR signalling events in human CD3(+) αβ T-cells.

The Notch signalling pathway is an important regulator of T cell function and is known to regulate the effector functions of T cells driven by T cell receptor (TCR). However, the mechanism integrating...

Signalling for B cell survival.

The number of mature B cells is carefully controlled by signalling from receptors that support B cell survival. The best studied of these are the B cell antigen receptor (BCR) and BAFFR. Recent work h...

Clinical Trials [6491 Associated Clinical Trials listed on BioPortfolio]

A Notch Signalling Pathway Inhibitor for Patients With T-cell Acute Lymphoblastic Leukemia/Lymphoma (ALL)(0752-013)

A Notch signalling pathway inhibitor study in pediatric and adult patients with relapsed (worsening) or refractory (not responding to treatment) T-cell acute lymphoblastic leukemia/lymphom...

Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma

This randomized phase I/II clinical trial is studying the side effects and best dose of gamma-secretase/notch signalling pathway inhibitor RO4929097 when given together with vismodegib and...

Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Recurrent or Progressive Glioblastoma

This phase II clinical trial is studying how well RO4929097 works in treating patients with recurrent or progressive glioblastoma. RO4929097 may stop the growth of tumor cells by blocking ...

Gamma-secretase/Notch Signalling Pathway Inhibitor RO4929097 in Combination With Cisplatin, Vinblastine, and Temozolomide in Treating Patients With Recurrent or Metastatic Melanoma

This phase Ib/II trial studies the side effects and best dose of gamma-secretase/Notch signalling pathway inhibitor RO4929097 when given together with cisplatin, vinblastine, and temozolom...

The Role of GLP-1 Receptor Signalling in the Glucose-lowering Effect of Metformin in Patients With T2D

Delineation of the role of glucagon-like peptide-1 receptor signalling in the glucose-lowering effect of metformin during meal ingestion in patients with type 2 diabetes.

Companies [1538 Associated Companies listed on BioPortfolio]


SUGEN is a biopharmaceutical company focused on the discovery and development of small molecule drugs which target specific cellular signal transduction pathways. These signalling pathw...

Cell Signalling Technology Incorporated

CST offers a broad array of new reagents to assist in the discovery of how proteins are regulated and function within the cell. These cutting edge tools are designed to advance the understanding of Pr...

TGR BioSciences Pty Ltd

TGR BioSciences Pty Ltd (TGR) is a private company located in Adelaide, Australia. Established in 2001, TGR is committed to providing innovative solutions for cell-based research applications. Our s...


PRAECIS PHARMACEUTICALS INCORPORATED is a biopharmaceutical company focused on the discovery and development of novel compounds to address unmet medical needs or improve existing therapies.PRAECIS has...

One Cell Systems, Inc.

One Cell Systems is developing and marketing a family of single cell assays that rely on microencapsulation and flow cytometry. Technology underlying these products has been developed internally and l...

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