Interleukin Genetics Company Profile

10:41 EST 18th November 2017 | BioPortfolio

Interleukin Genetics aims to be the world leader in understanding the genetics of inflammation, one of the body's most important defense mechanisms. Our scientists and clinicians study how common variations in several genes, especially three (known as IL-1a, IL-1b, and IL-1RN) affect an individual's response to the injuries caused by chronic diseases or disabilities such as coronary artery disease, diabetes, and osteoporosis. Our other major research effort will be to understand how variations in these genes affect an individual's response to therapy, a field known as pharmacogenetics. In 2002-2003 we will focus our pharmacogenetic efforts on therapies for rheumatoid arthritis.

Interleukin Genetics intends to be the first “Personalized Medicine” company. Our core mission is to develop genetic tests to warn people about increased risk for disease and to develop preventive and therapeutic options to avoid those diseases. We will use genetic information to help persons stay healthy from birth to a vigorous old age.

The company has the product PST®, a "DNA test" that assesses risk for periodontal disease. In non-smokers the biggest risk factor for periodontitis is genetic. The results from this cheek-swab test can help your dentist decide whether you need special preventive care to avoid this disorder.

The company, working closely with scientists at the University of Sheffield in England, is searching for genes that make proteins that substantially influence the impact of IL-1 on the body's Inflammatory Response. In 2000 we discovered the first such genes, and in 2001 filed our first patent covering their role as drug targets, e.g. as entities that could become the focus of a major research effort to develop new medicines.

Interleukin Genetics believes that its study of the role of inflammation in Coronary Artery Disease (CAD) can be the basis for a decision to greatly enlarge the population of individuals who are understood to benefit from long term use of an already widely prescribed group of cholesterol lowering drugs called "statins" to reduce their risk of heart attacks. Over the last few years cardiologists have come to realize that the development of coronary artery disease in individuals may be strongly influenced by how their body responds to the chronic injury of a high cholesterol diet. In effect inflammation plays an important role in the development of CAD. Currently, physicians do not prescribe statins for persons with moderately elevated levels of low density lipoprotein (LDL or "bad cholesterol"). However, we have performed studies that strongly suggest that persons who have moderately elevated LDL AND one of the common (carried by about 1 in 3 people) variants of an IL-1 gene are at significantly increased risk for heart disease and therefore would benefit from statin therapy. More than 10 million adult Americans have both these risk factors.

We are proud to be engaged in a major research agreement with Kaiser Permanente to understand the degree to which the risk for heart attacks faced by persons with diabetes is influenced by their IL-1 genotype. We expect to complete this study in the fall of 2002.


135 Beaver Street
United States of America


Phone: 781 398 0700
Fax: 781 398 0720

News Articles [518 Associated News Articles listed on BioPortfolio]

Interleukin Genetics to reduce workforce

Interleukin Genetics, Inc. has announced that it will pursue strategic alternatives for the Company and will reduce the Company’s workforce by five employees (63%) as part of a plan to reduce opera...

Interleukin Genetics slashes workforce, explores options

The genetics testing company is evaluating strategic alternatives, and plans to shutter one of its lead programs and dismiss more than half its staff.

Interleukin Genetics to cut workforce and explore alternatives

Interleukin Genetics Files Form 15

  Life Sciences Jobs   ...

Interleukin Genetics Slashes 63% of Workforce, Shuts Down Program and Mulls Sale

Learning From Failure: What Theranos, Interleukin Genetics, & Courtagen Can Teach Us About IVDs

  Life Sciences Jobs   ...

Massachusetts' Interleukin Genetics Slashes 63% of Workforce, Shuts Down Program and Mulls Sale

  Life Sciences Jobs   ...

[Comment] Potential efficacy of interleukin-1β inhibition in lung cancer

Over the past two decades, a wealth of experimental and clinical data have intimately linked dysregulated production of the potent proinflammatory cytokine interleukin 1β with several chronic inflamm...

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PubMed Articles [899 Associated PubMed Articles listed on BioPortfolio]

Temporal expression of interleukin-22, interleukin-22 receptor 1 and interleukin-22-binding protein during experimental periodontitis in rats.

Interleukin-22 (IL-22), mainly produced by CD4+ T-helper subtypes and innate lymphoid cells at barrier surfaces, is found to involve in several diseases, including diabetes, rheumatoid arthritis, peri...

Novel Biologic Agents Targeting Interleukin-23 and Interleukin-17 for Moderate-to-Severe Psoriasis.

Psoriasis is a common, chronic inflammatory skin disease and cannot be cured. The treatment of moderate-to-severe plaque psoriasis has been revolutionized with the development of biologic agents for n...

Polymorphisms of interleukin 6 in Down syndrome individuals: a case-control study.

Down syndrome (DS) individuals present impaired adaptive immune system. However, the etiology of the immunological deficiency in these individuals is not completely understood. This study investigated...

New Role for Interleukin-13 Receptor α1 in Myocardial Homeostasis and Heart Failure.

The immune system plays a pivotal role in myocardial homeostasis and response to injury. Interleukins-4 and -13 are anti-inflammatory type-2 cytokines, signaling via the common interleukin-13 receptor...

The Role of Interleukin-6 and Interleukin-8 Circulating Cytokines in Differentiating between Feeding Intolerance and Necrotizing Enterocolitis in Preterm Infants.

Clinical Trials [846 Associated Clinical Trials listed on BioPortfolio]

Genetics Education: Preparing Physicians for the Future

This study examines the best way to teach genetics to family medicine residents. First year family medicine residents at the University of Toronto will be taught basic clinical genetics as...

Interleukin-12 and Interleukin-2 in Treating Patients With Refractory or Recurrent Neuroblastoma

RATIONALE: Biological therapies use different ways to stimulate the immune system and stop cancer cells from growing. Combining interleukin-2 with interleukin-12 may kill more tumor cells....

Vaccine Therapy and Interleukin-12 With or Without Interleukin-2 in Treating Patients With Metastatic Melanoma

RATIONALE: Vaccines may make the body build an immune response to kill tumor cells. Interleukin-12 may kill tumor cells by stopping blood flow to the tumor. Interleukin-2 and interleukin-1...

Interleukin-2 and Interleukin-12 in Treating Patients With Refractory or Advanced Solid Tumors

RATIONALE: Interleukin-2 may stimulate a person's lymphocytes to kill solid tumor cells. Interleukin-12 may kill tumor cells by stopping blood flow to the tumor and by stimulating a person...

Experiences of Genetics Patients With Visible Abnormalities Who Facilitate Teaching in Genetics Clinics

This study will describe the experience of patients with visible physical abnormalities in the genetics clinic when they are involved in teaching others about their condition. Information ...

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