PathoGenesis Corporation Company Profile

10:21 EST 13th December 2018 | BioPortfolio

PathoGenesis Corporation develops and markets novel drugs to treat serious, chronic human infectious diseases where there is a significant need for improved therapy. In December 1997, the U. S. Food and Drug Administration approved ourfirst drug, TOBI (tobramycin solution for inhalation). TOBI is indicated for the management of cystic fibrosis (CF) patients with Pseudomonas aeruginosa lung infections. PathoGenesis Corporation began marketing TOBI in 1998 in the U.S., and generated $60.7 million in sales during the year. TOBI was approved for sale in Canada and Argentina in February 1999. PathoGenesis Corporation have filed for regulatory approvals in Europe and Australia. Applications in other countries are pending.


201 Elliott Avenue W. Suite 150
United States of America


Phone: 206 467 8100
Fax: 206 270 3313

News Articles [142 Associated News Articles listed on BioPortfolio]

Pathogenesis of Cushing Disease

A better understanding of the pathogenesis of Cushing disease could lead to the identification of therapeutic targets. Endocrine Practice

TEDDY: More Small Clues to the Pathogenesis of Type 1 Diabetes

Latest TEDDY findings point to childhood infections, in particular gastrointestinal infections, as drivers of islet autoimmunity subtypes in the pathogenesis of type 1 diabetes. Medscape Medical New...

Demodex Mites and Immune Reaction in Pathogenesis of Rosacea

Is interaction of Demodex mites with the host immune system instrumental in the pathogenesis of rosacea? The British Journal of Dermatology

Gut microbiota could play greater role in pathogenesis of MS than previously thought

In multiple sclerosis, a defective response of the body’s own immune system leads to brain tissue damage. Gastrointestinal microbiota could play a far greater role in the pathogenesis of the disease...

Fatty liver disease pandemic needs 'gold standard' human-relevant research

(Humane Society International) New study calls for human-based tools to unravel the pathogenesis of non-alcoholic steatohepatitis (NASH). The contribution of in silico, in vitro and pathways-based sys...

[Comment] Autoimmune encephalitis after herpes simplex encephalitis: insights into pathogenesis

There have been substantial advances in the recognition and treatment of autoimmune causes of encephalitis, particularly encephalitis associated with antibodies to neuronal cell-surface and synaptic a...

Georgia State researcher gets $419,100 grant to study virus similar to Ebola virus

(Georgia State University) Dr. Christopher Basler, a professor in the Institute for Biomedical Sciences at Georgia State University, director of the university's Center for Microbial Pathogenesis and ...

{alpha}-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson's disease

Dopaminergic neurodegeneration in Parkinson's disease (PD) is associated with abnormal dopamine metabolism by MAO-B (monoamine oxidase-B) and intracellular α-Synuclein (α-Syn) aggregates, ...

PubMed Articles [426 Associated PubMed Articles listed on BioPortfolio]

Pathogenicity-island-encoded regulatory RNAs regulate bacterial virulence and pathogenesis.

Bacterial regulatory RNAs (regRNAs) have been widely studied for decades and shown to be involved in various aspects of bacterial survival, including their virulence and pathogenesis. Recently, many r...

Recent advances in mouse models for systemic sclerosis.

SSc is a complex rheumatoid disease characterized by autoimmunity, fibrosis and vasculopathy. Mouse models provide powerful research tools for exploring the pathogenesis of the human diseases. Each mo...

Research advance of microRNA in the pathogenesis of chronic rhinosinusitis.

Chronic rhinosinusitis (CRS) is a common disease of otorhinolaryngology head and neck surgery, manifested as nasal-sinus mucosal chronic inflammation. However, the pathogenesis of CRS is not clear. Th...

Cofactor-Independent Antiphospholipid Antibodies: Implications for Pathogenesis, Diagnosis, and Treatment of Antiphospholipid Syndrome.

The antiphospholipid syndrome (APS) has occupied haemostaseologists, rheumatologists and obstetricians since its initial description 35 years ago. Its name has been coined because of the antibodies ag...

Pro-inflammatory role of transient receptor potential canonical channel 6 in the pathogenesis of chronic rhinosinusitis with nasal polyps.

The pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) has not been fully elucidated. This study sought to explore the role and mechanism of transient receptor potential canonical chann...

Clinical Trials [607 Associated Clinical Trials listed on BioPortfolio]

Adrenal Tumors - Pathogenesis and Therapy

The pathogenesis of adrenal tumors is still not fully elucidated and the treatment options for malignant tumors are poor. The current study investigates different aspects of the pathogenes...

Pathogenesis of Primary Spontaneous Pneumothorax

Primary spontaneous pneumothorax most commonly occurs in young, tall, lean males. The estimated recurrence rate is 23-50% after the first episode and increases to 60% after the second pneu...

Role of Amino Acids and Genetic Disorder in Pathogenesis of Heart Failure

Heart failure (HF) is a continuously growing public health problem. The study aim to provide novel insights into the role of amino acids in pathogenesis of heart failure, to obtain a bette...

HIV Diversity and Pathogenesis in Donor-Recipient Clusters

To assess, in donor-recipient clusters, current models of HIV-1 genetic evolution and pathogenesis, based on the sequence diversity displayed by this lentivirus.

The Scleroderma Biorepository and Pathogenesis Study (STOP Scleroderma)

The Scleroderma bioreposiTOry and Pathogenesis Study (STOP Scleroderma) will help researchers use clinical data and human biospecimens to investigate why scleroderma patients develop certa...

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PathoGenesis Corporation

PathoGenesis Corporation develops and markets novel drugs to treat serious, chronic human infectious diseases where there is a significant need for improved therapy. In December 1997, the U. S. Food ...

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