Replicon Technologies Incorporated Company Profile

21:54 EDT 21st March 2019 | BioPortfolio

Replicon Technologies, Inc. (RTI) is an emerging biotechnology company focused on the use of replicons, non-replicating RNA viral particles, for the treatment of patients with cancer. RTI is founded on research and development performed at the University of Alabama at Birmingham (UAB), and supported by competitive grants from the National Institutes of Health, the Department of Defense, and SBIR grants from the National Cancer Institute.

RTI’s replicons are oncolytic in a broad range of cancers, can cross the blood brain barrier, and efficiently diffuse through CNS tissue to sites of metastases. Replicons are highly selective for tumors due to up-regulation of the poliovirus receptor (CD-155) on cancer cells. Product development is focused on treatment of patients with primary brain cancers and metastases of cancers to the CNS, an area of cancer treatment for which replicons are uniquely suited due to their natural tropism for CNS tissues. The CNS is an area where current therapeutic alternatives of chemotherapy and radiation are minimally effective and cause excessive morbidity. Moreover, there are few, if any, viable new therapies in development for the specialized area of treating brain metastases or cancers to the CNS.


828 Eastbrook Court
United States of America


Phone: (925) 736 1863
Fax: (925) 736 5910

News Articles [301 Associated News Articles listed on BioPortfolio]

High-throughput neutralization assay for multiple flaviviruses based on single-round infectious particles using dengue virus type 1 reporter replicon

Gene Replacement in Tomato, Achieved Using CRISPR-Cas9 and Replicon

CRISPR-Cas9 can be used to produce two types of gene edits, namely NHEJ and HDR repairs. The NHEJ repair is done by allowing the natural repairing system of the cells inside the plant to create new co...

CERESPIR INCORPORATED and the NATIONAL NEUROSCIENCE INSTITUTE SINGAPORE Announce Positive Data Showing Beneficial Effects of CERESPIR’s Clinical Stage Compound Itanapraced in a LRRK2 Model of Parkinson’s Disease 

Itanapraced blocks LRRK2 expression and LRRK2-mediated neurotoxicity Itanapraced ready to advance to Phase 2 in Parkinson’s disease patients with and without genetic mutation NEW YORK and SINGAPO...

DBV Technologies S.A.: DBV Technologies to Attend Upcoming Investor Conferences

Montrouge, France, March 1, 2019 DBV Technologies to Attend Upcoming Investor Conferences DBV Technologies (Euronext: DBV - ISIN: FR0010417345 - Nasdaq Stock Market: DBVT), a clinical-stage biophar...

Lee Technologies Wins Award For Advanced Chemical Science Lab

Lee Technologies Group (Lee Technologies; Fairfax, VA), has won the 1999 Washington Building Congress Inc. Craftsmanship Award...

BioStem Technologies filing four pre-investigational new drug applications by end of year

BioStem Technologies, Inc. is a global life sciences corporation, providing innovative technologies with a concentration in Pharmaceuticals and Regenerative Medicine.

Study: New technologies leading to less traditional store checkouts

According to a study by Z

Excelitas acquires Axsun Technologies

Excelitas Technologies Corp., a global technology leader focused on delivering innovative, customized photonic solutions, has completed the acquisition of Axsun Technologies.

PubMed Articles [353 Associated PubMed Articles listed on BioPortfolio]

Generation of VHSV replicon particles carrying transmembrane and C-terminal cytoplasmic region-deleted G gene (rVHSV-GΔTM) and comparison of vaccine efficacy with G gene-deleted VHSV (rVHSV-ΔG).

Vaccines based on viral replicon particles would be advantageous to induce immune responses compared to inactivated viruses in that they can infect host cells (only once) and can produce viral protein...

Withdrawal: Hepatitis C virus NS5A and subgenomic replicon activate NF- κ B via tyrosine phosphorylation of I κ B α and its degradation by calpain protease.

Adoption of Stroke Rehabilitation Technologies by the User Community: Qualitative Study.

Using technology in stroke rehabilitation is attractive. Devices such as robots or smartphones can help deliver evidence-based levels of practice intensity and automated feedback without additional la...

Application of Digital Technologies in Maxillofacial Prosthetics Literature: A 10-Year Observation of Five Selected Prosthodontics Journals.

To identify trends in the application of various types of digital technologies in maxillofacial prosthetics by identifying these digital technologies and their characteristics and reviewing the preval...

Information and communication technologies for weight loss.

The potential of information and communication technologies has quickly been identified for health and in particular to promote weight loss. Several types of technologies exist with varying degrees of...

Clinical Trials [492 Associated Clinical Trials listed on BioPortfolio]

A Clinical Trial of an Alphavirus Replicon Vaccine for Cytomegalovirus (CMV)

AVX601, a bivalent alphavirus replicon vaccine expressing three CMV proteins (gB, pp65 and IE1) is a candidate vaccine against cytomegalovirus (CMV). The objectives of this Phase 1 study ...

A Phase 1/2 Clinical Trial of an Alphavirus Replicon Vaccine for Influenza

AVX502, an alphavirus replicon vaccine expressing an influenza HA protein, is a candidate vaccine against influenza. The objectives of this Phase 1 study are to test the safety of the vac...

Application of Monitoring and Intervention Technologies in Suboptimal Health Status

The purpose of this study is to use monitoring and intervention technologies in suboptimal health status in a general population in China and evaluate the effectiveness of these technologi...

Wheeze Detection in Adults During Dynamic Bronchial Situations Measured by PulmoTrack® 2010 With WIM-PC™ Technologies Recording

The PulmoTrack® 2010 with WIM-PC™ Technologies device, indicated for acoustic pulmonary function measurement that quantifies the presence of wheezing. This study was designed in order t...

Testing Latest Version of NidekRS3000Adv

The investigators would like to know if different imaging devices can improve the quality of images and visualization of imaged tissues. Also, the investigators would like to find out whet...

Companies [1335 Associated Companies listed on BioPortfolio]

Replicon Corporate Finance Oy/Ltd

Replicon is privately held, independent investment banking service company located in Helsinki, Finland. We provide first-class corporate finance and strategic advisory to our clients. Our range of ex...

Replicon Technologies Incorporated

Replicon Technologies, Inc. (RTI) is an emerging biotechnology company focused on the use of replicons, non-replicating RNA viral particles, for the treatment of patients with cancer. RTI is founded ...


Founded in 2008 by the Axis Biotec Brasil™ group (, PharmaPraxis has incorporated technologies, and will develop and launch biologic products in Brazil....


PRAECIS PHARMACEUTICALS INCORPORATED is a biopharmaceutical company focused on the discovery and development of novel compounds to address unmet medical needs or improve existing therapies.PRAECIS has...

SQI Diagnostics Inc.

SQI Diagnostics is a life sciences company that develops and commercializes proprietary technologies and products for advanced microarray diagnostics. The Company’s proprieta...

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