Steroidogenesis Inhibitors International Company Profile

07:30 EST 17th December 2018 | BioPortfolio

Drug Discovery


2001 East Flamingo Boulevard Suite 100B
Las Vegas
United States of America


Phone: 702 735 7001
Fax: 702 737 7016

News Articles [864 Associated News Articles listed on BioPortfolio]

DNA damage response induced by Etoposide promotes steroidogenesis via GADD45A in cultured adrenal cells

Hepatotoxicity of Immune Checkpoint Inhibitors

Immune checkpoint inhibitors have proven utility as a new class of anticancer drugs, but carry with them the risk of hepatotoxic and other immune-related adverse events. Liver International

Medical News Today: What are protease inhibitors for HIV?

Protease inhibitors are a class of HIV medication. They block the function of HIV protease enzymes. Taken with other antiretroviral drugs, protease inhibitors help prevent HIV from multiplying. Brand ...

PI3K Inhibitors: You’re Doing It Wrong

Now here’s an interesting connection between cancer and metabolism, with what look to be direct implications for therapy. A large research team (mostly working out of Weill Cornell) reports some...

Research Suggests JAK Inhibitors May Cause Aggressive Lymphoma

Austrian researchers have reported that a small number of patients taking Janus kinase (JAK) inhibitors to treat myelofibrosis may develop […] The post Research Suggests JAK Inhibitors May Cause...

BET Inhibitors Form a Growing Area of Epigenetic Cancer Research

Rapid progress in the development of BET inhibitors has created a surge of enthusiasm.

BTK Inhibitors: Real-World Insights on Patient Management and Therapy Selection

Nathan H. Fowler, MD, discusses the use of BTK inhibitors in B-cell malignancies.

Should TNF Inhibitors Be Used in Patients with Prior Malignancies?

This observational study implies that tumor necrosis factor inhibitors do not confer risk for cancer recurrence.

Drugs and Medications [437 Associated Drugs and Medications listed on BioPortfolio]

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Drug Facts

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PubMed Articles [1846 Associated PubMed Articles listed on BioPortfolio]

Maternal BDE-209 exposure during lactation perturbs steroidogenesis, germ cell kinetics and THRα1 expression in testes of prepubertal mice offspring.

Decabromodiphenyl ether (BDE-209), a congener of Polybrominated diphenyl ethers (PBDEs), is used as flame retardant and affects thyroid homeostasis. Thyroid hormones (THs) play crucial role in Leydig ...

The effects and possible mechanisms of triclosan on steroidogenesis in primary rat granulosa cells.

Triclosan (TCS) has been detected in human tissues. It can disrupt steroidogenesis in vivo. The study on the effects of TCS on ovarian granulosa cells was lacking.

Proton Pump Inhibitors and the Risk of Dementia: is There a Link?

Dementia is one of the most common neurodegenerative disorder among older populations around the world, and the incidence is increasing. Many epidemiologic studies have considered the association betw...

Monogenic Disorders of Adrenal Steroidogenesis.

Disorders of adrenal steroidogenesis comprise autosomal recessive conditions affecting steroidogenic enzymes of the adrenal cortex. Those are located within the 3 major branches of the steroidogenic m...

Associations between repeated measures of maternal urinary phthalate metabolites during pregnancy and cord blood glucocorticoids.

Previous studies have suggested that phthalates might disrupt fetal steroidogenesis. However, the evidence of the effects of prenatal phthalate exposure across pregnancy on fetal glucocorticoids was i...

Clinical Trials [2248 Associated Clinical Trials listed on BioPortfolio]

Human Chorionic Gonadotropin Stimulation Effects on Steroidogenesis in Men With Klinefelter Syndrome

The study design included six visits. During the first visit (visit 0), the subjects underwent physical examination(height, weight, body mass index (BMI), arm span, and upper segment measu...

Impact of Renin-Angiotensin System Inhibitors Continuation on Outcome After Major Surgery

More than 200 million major surgical procedures are performed annually worldwide. Many of these patients have comorbidities including hypertension and/or heart failure. Chronic treatment o...

The Malmö International Brother Study (MIBS)

Existing data support the concept that a genetic predisposition for inhibitor development exists. The aim of the Malmö International Brother Study (MIBS) is to evaluate genetic factors a...

Genetic Susceptibility to Factor VIII Inhibitors

This international study will identify genetic factors that may influence the development of inhibitory antibodies in patients with hemophilia A after treatment with factor VIII. Bleeding ...

Effects of Achieving Very Low LDL-Cholesterol After Treatment With Statins on Steroidogenesis and Cognition

We aimed to compare the effect of achieving an LDL-cholesterol

Companies [1449 Associated Companies listed on BioPortfolio]

Steroidogenesis Inhibitors International

Drug Discovery

Amura Holdings Ltd

Amura has two complementary technology platforms which enable rapid and innovative drug discovery. AMcore™, the bicyclic core molecular scaffold chemistry and the computational screening and design...

Step Pharma

Step Pharma is focused on the development of a novel class of oral nucleotide synthesis inhibitors targeting CTPS1 for the improved treatment of a range of autoimmune diseases. Th...

Viamet Pharmaceuticals, Inc.

Viamet discovers and develops novel inhibitors of key metalloenzymes via an innovative and proprietary metal-binding approach, the Metallophile™ Technology. Viamet’s dis...

Amura Therapeutics Ltd

Amura has two complementary technology platforms which enable rapid and innovative drug discovery. AMcore™, the bicyclic core molecular scaffold chemistry and the computational screening and design...

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