Structural GenomiX Incorporated Company Profile

04:02 EDT 17th October 2017 | BioPortfolio

Structural GenomiX (SGX) is revolutionizing the use of protein structure in the drug discovery process, helping to create safer, more effective medicines. Using high-throughput structural biology, SGX is translating the wealth of genetic and genomic information generated over recent years into structural templates for drug discovery, on an industrial scale. Availability of the 3-dimensional structure of a protein target can aid drug discovery at many points in the process, particularly in lead discovery and optimization, as well as at the earlier stages of target identification and validation.

Historically, it has been expensive, difficult and time-consuming to obtain structures of proteins early enough in the drug discovery process for the information to have an impact. Our state-of-the-art technology platform leverages our experimental and computational technologies to provide high-resolution views of protein structures much faster than was previously possible.

In addition to solving the structures of the distinct targets, SGX also solves the structures of the targets bound to compounds selected from chemical libraries. Known as "co-crystal" structures, these detailed images allow chemists to directly visualize how compounds bind to the target of interest, and therefore enables them to make informed decisions about how to improve upon chemistry "leads".

At present, optimization of lead compounds is a key bottleneck for pharmaceutical R&D programs. Our platform is designed to provide the right structure at the right time, for our partners and our internal programs, thereby accelerating the lead optimization process and helping to bring more effective medicines to market.


10505 Roselle Street
San Diego
United States of America


Phone: 858.558.4850
Fax: 858.558.4859

News Articles [182 Associated News Articles listed on BioPortfolio]

#jobs #lifescience GPCR structural biology

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: GPCR structural biology . Positions are available for individuals with str...

MRI evidence of structural changes in the sacroiliac joints of patients with non-radiographic axial spondyloarthritis even in the absence of MRI inflammation

Studies have shown that structural lesions may be present in patients with non-radiographic axial spondyloarthritis (nr-axSpA). However, the relevance of structural lesions in these patients is unclea...

Medical News Today: Adult brains undergo structural changes earlier than we thought

Contrary to common belief, the human brain undergoes structural changes during early to mid-adulthood, according to an analysis of scans of white matter.

Teens' ability to consider the intentions of others linked to structural changes in the brain

(Dartmouth College) When it comes to the concept of fairness, teenagers’ ability to consider the intentions of others appears to be linked to structural changes underway in the brain, according to a ...

#jobs #lifescience EMBL: Postdoctoral Fellow – Structural and Molecular Biology

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: EMBL: Postdoctoral Fellow – Structural and Molecular Biology . Competit...

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

Structural insight into TIR-domain interactions, which are essential for the recruitment of signaling adapters to Toll-like receptors during innate immune responses, demonstrates a conserved interacti...

OU provides NSF undergraduate research experience in structural biology

(University of Oklahoma) The National Science Foundation Undergraduate Research Program in Structural Biology at the University of Oklahoma provides a research experience for students who do not have ...

#jobs #lifescience Structural Biophysics PhD Fellow Opening @ Copenhagen University Denmark

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Structural Biophysics PhD Fellow Opening @ Copenhagen University Denmark . St...

PubMed Articles [721 Associated PubMed Articles listed on BioPortfolio]

Inclusion of diverse populations in genomic research and health services: Genomix workshop report.

Clinical genetic services and genomic research are rapidly developing but, historically, those with the greatest need are the least to benefit from these advances. This encompasses low-income communit...

Integrating and Assessing Structural Competency in an Innovative Prehealth Curriculum at Vanderbilt University.

Structural competency is a framework for conceptualizing and addressing health-related social justice issues that emphasizes diagnostic recognition of economic and political conditions producing and r...

Protein structural motifs in prediction and design.

The Protein Data Bank (PDB) has been an integral resource for shaping our fundamental understanding of protein structure and for the advancement of such applications as protein design and structure pr...

Three-dimensional Integrated Functional, Structural, and Computational Mapping to Define the Structural "Fingerprints" of Heart-Specific Atrial Fibrillation Drivers in Human Heart Ex Vivo.

Structural remodeling of human atria plays a key role in sustaining atrial fibrillation (AF), but insufficient quantitative analysis of human atrial structure impedes the treatment of AF. We aimed to ...

Structurexplor: A platform for the exploration of structural features of RNA secondary structures.

Discovering function-related structural features, such as the cloverleaf shape of transfer RNA secondary structures, is essential to understand RNA function. With this aim, we have developed a platfor...

Clinical Trials [418 Associated Clinical Trials listed on BioPortfolio]

Surgery and Transcatheter Intervention for Structural Heart Diseases

This project aimed to optimize the therapeutic strategy for structural heart disease by choosing optimal treatment, such as,surgical treatment,interventional and surgery combined with inte...

Diagnosis of Structural Sacroiliitis in Patients With Suspicion of Spondyloarthritis (EchoSPA)

The aims of this study are: 1° to assess the value of pelvic radiography and sacro-iliac joint (SIJ) MRI compared to CT scan of SIJ for the diagnosis of structural sacro-iliitis and 2° t...

A Cognitive Behavioral And Structural HIV Prevention Intervention for Young Ugandan Sex Workers

This study develops and tests a behavioural and structural intervention to prevent unprotected sex among young female sex workers. Half the participants will receive the intervention and h...

The Postural Control in Individuals With the Structural Leg-length Discrepancy

The structural leg-length inequality caused by the shortening of a segment of an extremity, results in an altered position of lower limb joints, the pelvis and the spine in static as well ...

Structural Brain Abnormalities in Children Born Prematurely: New Detection Methods and Clinical-Pathological Correlates

The purpose of the study is to detect structural brain changes using MRI and to correlate these findings with neurodevelopmental assessments in two-year old children previously enrolled in...

Companies [137 Associated Companies listed on BioPortfolio]

Computable Genomix

Computable Genomix develops genetic biomarkers for pharmacogenomic and other applications. Using a cutting-edge computational approach, the company streamlines biomarker product d...

Capital Genomix, Inc.

Capital Genomix, Inc. is a biotechnology company headquartered in Gaithersburg, Maryland that provides a unique, comprehensive solution for the discovery and rapid development of novel antibody-based ...

Structural GenomiX Incorporated

Structural GenomiX (SGX) is revolutionizing the use of protein structure in the drug discovery process, helping to create safer, more effective medicines. Using high-throughput structural biology, SGX...

Capital Genomix

Capital Genomix possesses two proprietary technology platforms for the comprehensive analysis of genes and proteins. We are pursuing a strategy that will combine the two platforms to identify genes an...

Structural Bioinformatics Incorporated

Structural Bioinformatics, Inc. structural bioinformatics technology resource building the first comprehensive database of dynamic 3D structures of proteinbased drug targets.

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