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TolerRx Incorporated Company Profile

16:50 EST 18th November 2017 | BioPortfolio

TolerRx, Inc. is an emerging biopharmaceutical enterprise specializing in the discovery, development, and commercial launch of a novel class of therapies that induce and/or maintain immunological tolerance. These therapies are most appropriate for chronic conditions associated with adverse, misdirected, or undesirable immune responses. TolerRx's approach is unique and unprecedented, in that it will leverage proprietary technology involving the identification of a fundamental mechanism of immunoregulation in order to discover therapies that induce long-standing immunological quiescence or tolerance.

Tolerance is a normal immunological response that the body uses to recognize "self" from "non-self" (foreign agents or antigens). By inducing a state of tolerance to inciting (or disease-causing) antigens, TolerRx's approach to disease intervention is closest to the cause or etiology of immune-mediated diseases. As such, TolerRx's therapies will utilize natural control mechanisms of the immune system, the result of which is a long-standing, antigen- and disease-specific clinical effect. The technology has applications in settings of transplantation, chronic biologic protein administration, gene therapy, and autoimmunity. As such, the technology has significant clinical development opportunities.



Until now, the strategies of immunosuppression have been based on direct control of the immune system by continuous application of drugs. Current immunosuppressive therapies penalize the entire immune system by disarming multiple mechanistic pathways. They must be administered continuously and for extended periods of time, and they have numerous deleterious side effects. Withdrawal of these drugs largely results in relapse of disease. TolerRx's new strategy is designed to harness the body's own T cell-mediated tolerance mechanisms that have presumably evolved so as to be minimally harmful to the host. Thus, the mission of TolerRx is to create therapies aimed at reprogramming the immune system by changing its perception of disease-related or "self" antigens so as to become tolerant to them while preserving normal immunological competence.

Location

300 Technology Square, 4th Floor
Cambridge
MA
02139
United States of America

Contact

Phone: 617-354-8100
Fax: 617-354-8300
Email: info@TolerRx.com


News Articles [1 Associated News Articles listed on BioPortfolio]

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Companies [39 Associated Companies listed on BioPortfolio]

Toler RX Incorporated

TolerRx, Inc. is an emerging biopharmaceutical enterprise specializing in the discovery, development, and commercial launch of a novel class of therapies that induce and/or maintain immunological tole...

TolerRx Incorporated

TolerRx, Inc. is an emerging biopharmaceutical enterprise specializing in the discovery, development, and commercial launch of a novel class of therapies that induce and/or maintain immunological tole...

TolerRx, Inc.

We are a biopharmaceutical company focused on the discovery, development, and commercialization of novel therapies to treat patients with immunological diseases. TolerRx has a development pipeline whi...

PRAECIS PHARMACEUTICALS INCORPORATED

PRAECIS PHARMACEUTICALS INCORPORATED is a biopharmaceutical company focused on the discovery and development of novel compounds to address unmet medical needs or improve existing therapies.PRAECIS has...

Pharmapraxis

Founded in 2008 by the Axis Biotec Brasil™ group (www.axisbiotec.com.br), PharmaPraxis has incorporated technologies, and will develop and launch biologic products in Brazil....

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