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Today’s post is one for my fellow organic chemists to wonder over. This new paper from a group at the University of Bari describes a palladium-catalyzed coupling reaction of alkyllithiums and a...
GlaxoSmithKline (GSK) said today that it has sold mostly-global rights to its Phase III-bound psoriasis and atopic dermatitis candidate tapinarof (GSK2894512) to Dermavant Sciences for up to £250...
Aryl Hydrocarbon Receptor Class E Basic Helix Loop Helix Protein 76 or bHLHe76 or AHR Pipeline Review, H1 2018SummaryAryl Hydrocarbon Receptor Class E Basic Helix Loop Helix Protein 76 or bHLHe76 or ...
GSK announced that Dermavant Sciences, a subsidiary of Roivant Sciences, has agreed to purchase the rights to tapinarof, an investigational therapeutic aryl hydrocarbon receptor modulating agent (TAMA...
BF3·OEt2-mediated cross-coupling of (SnMe3)2 with aryl triazene offers a new strategy for the synthesis of aryl stannane. A variety of synthetically useful aryl trimethylstannanes were produced in mo...
Arylfullerenyl cations (ArC), which were generated by heating arylfullerenyl dimers (ArC-CAr) to generate arylfullerenyl radicals (ArC) followed by oxidation using Cu(II) salts (Cu(BF)(aq)...
The Pd-catalyzed regioselective C-H activation/arylation, /iodination, and/acetoxylation reactions of 4-arylpyrimidines using aryl iodides, N-iodosuccinimide, and (diacetoxyiodo)benzene respectively a...
Employing DABCO as a substrate, aryl(mesityl)iodonium triflates are introduced as arylating agents for a tertiary sp-nitrogen. Mild conditions and exceptional selectivity of the aryl group transfer al...
A series of new 1-aryl-6,7-dihydroxy tetrahydroisoquinolines with several substitution patterns in the 1-aryl group at C-1 were prepared in good yields. The influence of each substituent on the affini...
The prognosis for patients with metastatic or locally advanced hepatocellular carcinoma (HCC) is poor. The role of conventional systemic chemotherapy has been very limited because most ch...
This study will investigate the effects and side effects of BAY 43-9006 in patients with advanced, recurrent, or refractory non-small cell lung cancer (NSCLC). BAY 43-9006 is one of a new ...
ARYLS.A.started its business as a pharmachemical company in 1998.The manufacturing site and the administration offices are located in Bureros Aires,Aregentina.The Company employs more than 100 people
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