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11:12 EST 13th December 2018 | BioPortfolio

I obtained a Bachelor's degree at Oregon State University and Masters and Ph.D. degrees at the University of Minnesota. My doctoral thesis detailed a purification protocol for phytochrome, a plant pigment that regulates photomorphogenetic events in plant development. This work also characterized the hydrodynamic behavior of phytochrome, exploring size and shape parameters and subunit structure, and observed the effects of chemical cross-linking on its phototransformation. This work was extended at the University of California at Davis. Here, with Dr. J. Clark Lagarias, I was able to complete work on purification procedures that resulted in the isolation of phytochrome that was stable and unmodified with respect to in vivo characterizations using conventional protein purification methods.



News Articles [7 Associated News Articles listed on BioPortfolio]

Researchers Kill Liver-stage Malaria Parasite With Baculovirus

NewsAn insect virus, or baculovirus, can completely eliminate liver-stage malaria parasites, offering hope for safer, more effective treatments than existing drugs.

Killing the liver-stage malaria parasite with baculovirus: a drug discovery approach

(Kanazawa University) Currently, few antimalarial treatments exist that effectively kill liver-stage malaria parasite Plasmodium vivax, which can lay dormant for months or even years. Researchers at K...

Bac-2-the-Future: An Improved System for Production of Recombinant Baculovirus

Baculoviruses have been used for decades to produce proteins in insect cell hosts. Current systems for generating recombinant baculovirus have several shortcomings which prevent their easy use in high...

New Insect Sf9-ET Cell Line for Determining Baculovirus Titers

The baculovirus-based protein expression system has gained increased prominence as a method for expressing recombinant proteins that are used in a wide range of biomedical applications. An important s...

Baculovirus virion completely eliminates liver-stage parasites in mouse model

Currently, few antimalarial treatments exist that effectively kill liver-stage malaria parasites, which can lay dormant for months or years as in the case of Plasmodium vivax. Researchers from Kanazaw...

Researchers use moth viruses, magnets to fight diseases

Researchers from Rice University used CRISPR-Cas9 technology to modify a baculovirus, based on a virus that affects moths, b -More- 

Improved Production of Prenylated Protein in Insect Cells

KRAS and other Ras-family enzymes are an important component of over 30% of human cancers, however, no effective therapeutics targeting Ras or Ras-driven cancers are currently available.  The product...

Drugs and Medications [0 Results]


PubMed Articles [32 Associated PubMed Articles listed on BioPortfolio]

Genetics instability of wtAAV2 genome and AAV promoter activities in the Baculovirus/Sf9 cells system.

The human Adeno-Associated Virus serotype 2 (wtAAV2) is a common non-pathological virus and its recombinant form (rAAV) is widely used as gene therapy vector. Although rAAVs are routinely produced in ...

Expression and Purification of Recombinant Proteins Using the Baculovirus System.

This article describes how to analyze protein expression in cells infected with recombinant baculovirus on a small scale for optimizing protein production, how to maximize and scale up recombinant pro...

The Effect of Diet on Midgut and Resulting Changes in Infectiousness of AcMNPV Baculovirus in the Cabbage Looper, .

Insecticide resistance has been reported in many important agricultural pests, and alternative management methods are required. Baculoviruses qualify as an effective, yet environmentally benign, bioco...

Origins of truncated supplementary capsid proteins in rAAV8 vectors produced with the baculovirus system.

The ability to produce large quantities of recombinant Adeno-Associated Virus (rAAV) vectors is an important factor for the development of gene therapy-based medicine. The baculovirus/insect cell expr...

Functional Characterization of Carboxylesterases in Insecticide Resistant House Flies, Musca Domestica.

Carboxylesterase-mediated metabolism is thought to play a major role in insecticide resistance in various insects. Several carboxylesterase genes were found up-regulated in the resistant house fly str...

Clinical Trials [2 Associated Clinical Trials listed on BioPortfolio]

Influenza Vaccination in Patients Receiving Antineoplastic Therapy for Non-Hodgkin's Lymphoma

Primary Objective: 1. To assess the trend in immunogenic response across patients administered either licensed trivalent inactivated influenza vaccine (TIV) or one of three doses (15, 45 ...

Immunogenicity and Safety of FluBlok Trivalent Recombinant Hemagglutinin Influenza Vaccine in Healthy Pediatrics

The purpose of this study was to evaluate dose-related safety, reactogenicity and immunogenicity of FluBlok trivalent recombinant baculovirus-expressed hemagglutinin influenza vaccine, adm...

Companies [8 Associated Companies listed on BioPortfolio]

Oxford Expression Technologies

Oxford Expression Technologies is a world-renowned centre of excellence for baculovirus protein expression. We provide protein expression products, services and consultancy to many global pharmaceutic...

Protein Sciences Corporation

Protein Sciences Corporation biopharmaceutical service company that specializes in using the Baculovirus Expression Vector System to produce recombinant proteins.


Our goal is to provide quality reagents at affordable price for biomedical research. We also provide custom services for baculovirus, bacterial, and mammalian gene expression. Recently, we have introd...

Quantum Biotechnologies Incorporated

Quantum Biotechnologies Inc. supplier of molecular biology tools. adenovirus and baculovirus recombinant production kits, AutoFluorescent Proteins, positive selection vector, and custom nonradioactive...

AgriVirion Incorporated

AgriVirion is a contract protein production service provider with expertise in the production of baculovirus-coded recombinant proteins on scales that either cannot be achieved, or would be prohibitiv...

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