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Beta-Cell Company Profile

05:24 EST 14th December 2018 | BioPortfolio

Beta-Cell is engaged in the development and commercialisation of innovative cell and drug therapies for the treatment of diabetes. The primary therapeutic focus of the company is on beta-cells, the highly specialized endocrine cells located in pancreatic islets and responsible for producing insulin. Beta-Cell has an advanced pre-clinical xeno-transplantation program based on its proprietary technologies to isolate and transplant fetal pig pancreatic endocrine (FPPE) cells. As demonstrated by the company, transplanted FPPE cells have the ability to restore normoglycemia in immune competent diabetic mice. Follow-up experiments with FPPE cells in large animal models are in progress. Concurrently, Beta-Cell is conducting research projects aimed at stimulating the proliferation, survival and differentiation of precursor / stem cells into functional beta-cells. In addition to its core programs in beta-cell therapy, the company has adopted a dynamic business strategy to maximize the commercial potential of its different technology platforms. The first product made available in this process is the access to high-quality FPPE cells produced in large amounts under GLP conditions. The company also provides a combination of services using in vitro test systems based on pancreatic islets and endocrine / exocrine cells from rat, pig and human sources to accelerate the identification and validation of novel diabetes drug candidates. The third product currently commercialised by Beta-Cell is a robust murine in vivo model to evaluate drug candidates for the induction of immune suppression or immune tolerance upon xeno-transplantation. Finally, Beta-Cell is active in the development of innovative multiplex detection tools for porcine pathogens.

Location

Researchpark Z1 310
Zellik
1731
Belgium


News Articles [1449 Associated News Articles listed on BioPortfolio]

Transgenic Mice Expressing CNO-sensitive Gq- or Gs-coupled Designer Receptors Selectively in Pancreatic Beta Cells

Impaired functioning of pancreatic beta cells is a key hallmark of type 2 diabetes. Beta cell function is modulated by the actions of different classes of heterotrimeric G proteins. The functional con...

Alpha/beta T-cell and B-cell depletion haplo-HSCT is an effective treatment for children with acute leukaemia

Dr Franco Locatelli speaks to ecancer at ASH 2018 about a study into treating children with acute leukaemia with alpha/beta T-cell and B-cell depletion haplo-HSCT. He reports that the alpha/beta T-ce...

Islet Beta Cell Only M3 Muscarinic Acetylcholine Receptor Knockout Mouse

Researchers at NIH have developed islet beta cell M3 muscarinic acetylcholine receptor knockout mouse. The mice were generated by crossing floxed mouse M3 muscarinic acetylcholine receptor mice with m...

Beta cell biomarker findings may speed diabetes research

Researchers at Vanderbilt University Medical Center have identified a biomarker for insulin-producing beta cells. Their finding, reported this month in the journal 

Beta Cell-System Offers New Route for Type 2 Diabetes Drug Development

ArticleHarvard Bioscience has developed a non-invasive beta cell screening system for diabetes research that leverages multielectrode arrays (MEAs) to take measurements from intact pancreatic islets c...

New research sheds light on the causes of diabetes

The main cause of all forms of diabetes is pancreatic beta-cell dysfunction. Beta cells, found in the pancreatic islets, store and release insulin.

Transgenic Mice Overexpressing Islet Beta Cell M3 Muscarinic Acetylcholine Receptors

Researchers at NIH have generated transgenic mice in which the M3 muscarinic receptor is overexpressed in pancreatic beta cells. This was done by placing the receptor gene under the control of the 650...

Evotec Gets EUR 3 Mln Beta Cell Therapy Milestone Payment From Sanofi

PARIS (dpa-AFX) - Evotec AG (EVTCY.PK, EVOTF.PK) announced Monday that its strategic alliance with French drug giant Sanofi SA (SNYNF, SNY) in the field of diabetes has reached its second beta cel...

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PubMed Articles [3203 Associated PubMed Articles listed on BioPortfolio]

A proteomic signature that reflects pancreatic beta-cell function.

Proteomics has the potential to enhance early identification of beta-cell dysfunction, in conjunction with monitoring the various stages of type 2 diabetes onset. The most routine method of assessing ...

Activation of GLP-1 receptor signalling alleviates cellular stresses and improves beta cell function in a mouse model of Wolfram syndrome.

Loss of functional beta cells results in a gradual progression of insulin insufficiency in Wolfram syndrome caused by recessive WFS1 mutations. However, beta cell dysfunction in Wolfram syndrome has y...

TGF-beta/TGF-beta RII/CLC-3 axis promotes cognitive disorders in diabetes.

Transforming growth factor beta (TGF-beta) and Chloride channel-3 (CLC-3) are critical for inflammatory response, cellular proliferation and apoptosis in hippocampus neurons. However, the relationship...

Cell-Based Methods to Identify Inducers of Human Pancreatic Beta-Cell Proliferation.

Diabetes is the result of the insufficiency or dysfunction of pancreatic beta cells alone or in combination with insulin resistance. The replacement or regeneration of beta cells can effectively rever...

Increased mitochondrial fission is critical for hypoxia-induced pancreatic beta cell death.

Hypoxia-mediated pancreatic beta cell death is one of the main causes of pancreatic beta celldeath, which leads to the loss of functional pancreatic beta cell mass and type 1 diabetes andtype 2 diabet...

Clinical Trials [7582 Associated Clinical Trials listed on BioPortfolio]

Characterization of Beta Cell Failure

The purpose of this study is to characterise beta cell function in subjects who despite taking part in a diabetes prevention program (life style intervention with diet and exercise) exhibi...

LIraglutide and Beta-cell RepAir (LIBRA) Study

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by progressive deterioration in the function of the pancreatic beta-cells, which are the cells that produce an...

Beta-Cell Function and Sitagliptin Trial (BEST)

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by progressive deterioration in the function of the pancreatic beta-cells, which are the cells that produce an...

Visualizing Beta Cells in Patients With a History of Gestational Diabetes

In order to evaluate the difference in beta cell mass in women with and without a history of gestational diabetes mellitus (GDM), investigators aim to compare quantitative PET imaging of t...

Association Between Insulin Resistance and Beta Cell Function With HbA1C in Diabetics

Progression of T2DM is widely accepted to be contributed by two main components: beta cell function deterioration where insulin secretion is impaired and insulin resistance where insulin p...

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More Information about "Beta-Cell" on BioPortfolio

We have published hundreds of Beta-Cell news stories on BioPortfolio along with dozens of Beta-Cell Clinical Trials and PubMed Articles about Beta-Cell for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Beta-Cell Companies in our database. You can also find out about relevant Beta-Cell Drugs and Medications on this site too.

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