Cortical Pty Ltd Company Profile

13:39 EDT 21st September 2018 | BioPortfolio

Inflammatory diseases can be successfully targeted with anti-cytokine therapies. Small molecule cytokine antagonists have never previously been developed, but may provide a valuable combination of effectiveness in treatment, potential oral administration, and a cost which may allow more patients to receive the treatment. In addition such molecules have the potential for formulation for use as a topical treatment or as an aerosol.


27-31 Wright StClayton


Phone: 613 9594 7300
Fax: 613 9594 7311

News Articles [62 Associated News Articles listed on BioPortfolio]

Researchers identify molecular mechanism leading to cortical malformation from brain-only mutations

Focal malformations of cortical development are a heterogeneous group of brain cortical abnormalities.

Relapse in Major Depression Linked to Brain Cortical Changes

THURSDAY, March 29, 2018 -- For patients with major depressive disorder (MDD), relapse is associated with brain cortical changes over two years, according to a study published online March 28 in JAMA ...

Prenatal Folic Acid Fortification May Affect Cortical Development

MONDAY, July 9, 2018 -- Gestational exposure to folic acid fortification is associated with cortical development, according to a study published online July 3 in JAMA Psychiatry. Hamdi Eryilmaz, Ph.D....

A double-blind placebo-controlled cross-over clinical trial of DONepezil In Posterior cortical atrophy due to underlying Alzheimer's Disease: DONIPAD study

The study investigated whether donepezil exerts symptomatic benefit in patients with posterior cortical atrophy (PCA), an atypical variant of Alzheimer’s disease.

[Articles] Cortical neuronal densities and cerebral white matter demyelination in multiple sclerosis: a retrospective study

We propose that myelocortical multiple sclerosis is a subtype of multiple sclerosis that is characterised by demyelination of spinal cord and cerebral cortex but not of cerebral white matter. Cortical...

Increased cortical activation in cannabis users' brains in resting state, research suggests

Recent research shows that cannabis users experience increased cortical activation during the brain's resting state when compared with nonusers. The resulting 'noisy brain' might impair brain activity...

Researchers develop rapid, cost-effective method to create human cortical organoids

Writing in the current online issue of the journal Stem Cells and Development, researchers at University of California San Diego School of Medicine describe development of a rapid, cost-effective meth...

Research suggests increased cortical activation in cannabis users' brains in resting state

(Center for BrainHealth ) Recent research from the Center for BrainHealth® at The University of Texas at Dallas shows that cannabis users experience increased cortical activation during the brain's r...

Drugs and Medications [20 Associated Drugs and Medications listed on BioPortfolio]

Zonegran [Eisai Inc.]

ZONEGRAN (zonisamide) capsulesRx Only

Zonisamide capsules [ALPHAPHARM PARTY LTD]

Zonisamide Capsules

Lamotrigine tablets (chewable, dispersible) [Dr. Reddy's Laboratories Ltd]

Lamotrigine Tablets (chewable, dispersible)

Lamotrigine [American Health Packaging]


Zonisamide [AvPAK]

Zonisamide 100mg

PubMed Articles [662 Associated PubMed Articles listed on BioPortfolio]

PET staging of amyloidosis using striatum.

Amyloid PET data are commonly expressed as binary measures of cortical deposition. However, not all individuals with high cortical amyloid will experience rapid cognitive decline. Motivated by postmor...

Deterioration of Cortical Bone Microarchitecture: Critical Component of Renal Osteodystrophy Evaluation.

Cortical bone is a significant determinant of bone strength and its deterioration contributes to bone fragility. Thin cortices and increased cortical porosity have been noted in patients with chronic ...

A Multimodal Approach For Radical Excision Of Focal Cortical Dysplasia By Combining Advanced Mri Data To Intraoperative Ultrasound, Electrocorticography And Cortical Stimulation: A Preliminary Experience.

Type II focal cortical dysplasia is the most common malformation of cortical development associated with drug resistant epilepsy and susceptible to surgical resection. Although advanced imaging modali...

Bone Area Histomorphometry.

Quantifying the amount of cortical bone loss is one variable used in histological methods of adult age estimation. Measurements of cortical area tend to be subjective and additional information regard...

Amyloid-β-related and unrelated cortical thinning in dementia with Lewy bodies.

Coexisting Alzheimer's disease (AD) pathology is common in patients with dementia with Lewy bodies (DLB). To evaluate the cortical thinning in patients with DLB considering the effect of amyloid-β (A...

Clinical Trials [461 Associated Clinical Trials listed on BioPortfolio]

Physiopathology of Lower Cortical Activation in COPD Patients: Contribution of Cortical Neuromodulation

Patients with COPD have lower cortical activation and higher cortical inhibitory levels. The purpose of this study is to test the reversibility the lower cortical activation by counterbala...

Age Influence on Cortical Bone Measured by Ultrasound

The study of this study is to evaluate the age influence on cortical bone strength properties by two methods:HR-pQCT (HighResolution-peripheral quantitativeComputedTomography) and ultrasou...

Transcranial Magnetic Stimulation Study of Cortical Excitability as Marker of Antidepressant Response: EXCIPSY Study

Depression is a common issue but there is no marker of response to an antidepressant treatment.The measurement of variation of the cortical excitability in responders to a selective seroto...

The Effect of N-Acetyl Cysteine on Cortical Erosion in Early Stage Schizophrenia

The primary objective of this study is to determine if NAC, added to existing antipsychotic treatment, is superior to placebo for cortical erosion in patients with early stage psychosis. T...

Pathophysiology of Neuronal Oscillations Within Subthalamo-cortical Loops in Parkinson's Disease

Neuronal activity in circuits between the basal ganglia (BG) and motor cortical areas is abnormally synchronised and rhythmic. The oscillatory activity prevails at 8-30 Hz in untreated Par...

Companies [4 Associated Companies listed on BioPortfolio]

Cortical Pty Ltd

Inflammatory diseases can be successfully targeted with anti-cytokine therapies. Small molecule cytokine antagonists have never previously been developed, but may provide a valuable combination of eff...


Orthovita is a unique spine/orthopaedic surgical biomaterials company offering advanced bone regeneration and soft tissue healing technologies. Our experience lies in developing and distributing novel...

iPierian, Inc.

iPierian is a pioneering biopharmaceutical company focusing on harnessing the power of induced pluripotent stem cells (iPSCs) to discover novel therapies that are effective in add...

Orthovita, Inc.

Orthovita, Inc. is a specialty spine and orthopedic company with a portfolio of orthobiologic and biosurgery products. Our products are based on novel and unique proprietary bioma...

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Cytokine Tumour Necrosis Factor (TNF)
TNF is a compound that is classified as a cytokine which plays a central role in the cellular mechanisms of apoptosis or cell death. However, there are a number of different kinds of TNF, just under twenty, but the family of molecules have very similar a...

Cytokines include chemokines, lymphokines, and monokines. Cells of the immune system communicate with one another by releasing and responding to chemical messengers called cytokines. These proteins are secreted by immune cells and act on other cells to...

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