Chiasma (Israel), LTD Company Profile

05:57 EDT 25th June 2018 | BioPortfolio

Chiasma develops new drug products based on its proprietary Transient Permeability Enhancer (TPE) technology, which enables oral delivery of macromolecules (up-to 20 kDa) and poorly-absorbed small molecules into the GI wall, portal system and then to the systemic circulation. Chiasma creates its internal pipeline by selecting approved macromolecules that are currently available in injectable form, changing the route of administration to oral and evaluating them for new indications, thereby creating new drugs that will take advantage of the 505(b)(2) regulatory route in the US and similar regulations in other countries.

Chiasma’s lead candidate, Octreolin™, is a product in capsule form (administered orally) that contains octreotide acetate, a 1.0 kDa peptide in the TPE formulation. Octreolin has successfully completed a Phase I clinical study evaluating its safety and pharmacokinetics (PK). Octreolin demonstrated a PK profile similar to that of subcutaneously injected octreotide acetate. In addition, no serious adverse safety events were reported. Chiasma intends to begin a pivotal trial by the end of 2010 for acromegaly, a hormonal disorder that results from an excess of growth hormone (GH). The pool of patients eligible for Octreolin treatment is estimated to be between 10,000 and 15,000 in the US and an equal number in Europe.

Octreolin is also being developed as an oral treatment for patients with Portal Hypertension (PHT); no drugs are approved for PHT in the US. A Phase 2 trial for this new indication is expected to start in December of 2010.

The Company is also developing: (1) An oral peptide (switch from injectable) for a new CNS indication; and (2) An oral protein (switch from injectable) for a viral disease that may also result in improvements to the label.


POB 45182
10 Hartom Street


Phone: 972-2-571-5885
Fax: 972-2-571-5886

News Articles [421 Associated News Articles listed on BioPortfolio]

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The changing roles of community nurses: the case of health plan nurses in Israel.

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The importance of HPV testing for cervical cancer screening in Israel.

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Clinical Trials [140 Associated Clinical Trials listed on BioPortfolio]

Characteristics of Hgb C Carriers in Northern Israel and Clinical Features Among Hgb Homozygous

Hgb C is an hemoglobinopathy quite rare in Israel. The clinical status of patients that are diagnosed as homozygous to this disease is quite benign but not study in large groups. Also the...

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The aim of the present study was to describe the incidence and prevalence of IBD in non Jewish Israel population

Sickle Cell Anemia in an Arab Bedouin Village in the Northern Israel

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Group B Streptococcal Carrier State Prevalence Among Arab Pregnant Women in Northern Israel District

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Companies [240 Associated Companies listed on BioPortfolio]

Chiasma (Israel), LTD

Chiasma develops new drug products based on its proprietary Transient Permeability Enhancer (TPE) technology, which enables oral delivery of macromolecules (up-to 20 kDa) and poorly-absorbed small mol...

Chiasma, Inc.

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