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Chiasma (Israel), LTD Company Profile

05:57 EDT 25th June 2018 | BioPortfolio

Chiasma develops new drug products based on its proprietary Transient Permeability Enhancer (TPE) technology, which enables oral delivery of macromolecules (up-to 20 kDa) and poorly-absorbed small molecules into the GI wall, portal system and then to the systemic circulation. Chiasma creates its internal pipeline by selecting approved macromolecules that are currently available in injectable form, changing the route of administration to oral and evaluating them for new indications, thereby creating new drugs that will take advantage of the 505(b)(2) regulatory route in the US and similar regulations in other countries.

Chiasma’s lead candidate, Octreolin™, is a product in capsule form (administered orally) that contains octreotide acetate, a 1.0 kDa peptide in the TPE formulation. Octreolin has successfully completed a Phase I clinical study evaluating its safety and pharmacokinetics (PK). Octreolin demonstrated a PK profile similar to that of subcutaneously injected octreotide acetate. In addition, no serious adverse safety events were reported. Chiasma intends to begin a pivotal trial by the end of 2010 for acromegaly, a hormonal disorder that results from an excess of growth hormone (GH). The pool of patients eligible for Octreolin treatment is estimated to be between 10,000 and 15,000 in the US and an equal number in Europe.

Octreolin is also being developed as an oral treatment for patients with Portal Hypertension (PHT); no drugs are approved for PHT in the US. A Phase 2 trial for this new indication is expected to start in December of 2010.

The Company is also developing: (1) An oral peptide (switch from injectable) for a new CNS indication; and (2) An oral protein (switch from injectable) for a viral disease that may also result in improvements to the label.

Location

POB 45182
10 Hartom Street
Jerusalem
91450
Israel

Contact

Phone: 972-2-571-5885
Fax: 972-2-571-5886
Email: dana@chiasmapharma.com


News Articles [421 Associated News Articles listed on BioPortfolio]

GapSummit: Lessons for young scientists and innovators

Chiasma is one of our sister organisations; it operates across New Zealand, connecting young scientists with industry, and providing them with professional development. Jessica Chiang, one of our GapS...

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Chiasma shares surge after FDA agrees to redefine late-stage study endpoints

The biopharma is developing a drug to treat acromegaly, a pituitary gland disorder

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If Iran uses its Iraqi Shia Militias, Afghans, and Pakistanis, as well as its own forces in attacks on Israel, there is likely to be war between Israel and Iran by 2019. If Tehran uses its militias, ...

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PubMed Articles [134 Associated PubMed Articles listed on BioPortfolio]

The changing roles of community nurses: the case of health plan nurses in Israel.

In Israel, approximately one-third of the country's nurses work in community settings - primarily as salaried employees in Israel's four non-profit health plans. Many health system leaders believe tha...

The importance of HPV testing for cervical cancer screening in Israel.

Prevalence and Genotype Distribution of HPV Types in Women at Risk for Cervical Neoplasia in Israel.

Invasive cervical cancer is caused by human papillomavirus (HPV).

Fatal Overdoses of Opioids in Israel 2005-2014.

To explore previously unreported rates and trends in opioid-related mortality in Israel, 2005-2014.

FORCE-FEEDING OR LIFE-SAVING? - DEALING WITH HUNGER STRIKES IN ISRAEL.

Force feeding of fasting hunger-striking prisoners is the subject of considerable controversy in Israel and elsewhere, posing a direct conflict between two basic ethical values: that of human life and...

Clinical Trials [140 Associated Clinical Trials listed on BioPortfolio]

Characteristics of Hgb C Carriers in Northern Israel and Clinical Features Among Hgb Homozygous

Hgb C is an hemoglobinopathy quite rare in Israel. The clinical status of patients that are diagnosed as homozygous to this disease is quite benign but not study in large groups. Also the...

Israeli Multi Ethnic Centenarian Project

This study will systematically assess epigenome methylation changes in participants of the Israel multi-ethnic centenarian study cohort, which includes citizens of Israel aged 95 years and...

Epidemiology of Ulcerative Colitis and Crohn's Disease in Non Jewish Israel Population

The aim of the present study was to describe the incidence and prevalence of IBD in non Jewish Israel population

Sickle Cell Anemia in an Arab Bedouin Village in the Northern Israel

Sickle cell anemia and sickle cell thalassemia are frequent diseases among the israeli arab population. The purpose of this study is to assess the clinical characteristics of the patients ...

Group B Streptococcal Carrier State Prevalence Among Arab Pregnant Women in Northern Israel District

The incidence of early neonatal GBS (group B Streptococcus) infection in the Nazareth Hospital through the years 2006-2013 has been higher compared to the national average. On reviewing al...

Companies [240 Associated Companies listed on BioPortfolio]

Chiasma (Israel), LTD

Chiasma develops new drug products based on its proprietary Transient Permeability Enhancer (TPE) technology, which enables oral delivery of macromolecules (up-to 20 kDa) and poorly-absorbed small mol...

Chiasma, Inc.

ILSI Biomed Israel 2011

The ILSI Biomed Israel 2011 is the central annual event of Israel's life science industry. It consists of an international professional conference, targeted at the best experts an...

EpiSafe Medical Devices Ltd

EpiSafe is a privately held medical device company dedicated to the development and manufacture of medical devices for the oral cavity. It was founded in 2002 by Eran Lavi, who serves as CEO of the co...

IATI-BioMed Conference

IATI, run by CEO Karin Mayer Rubinstein is the largest umbrella organization representing the hi-tech and life sciences industries. With over 450 members, its mission is to streng...

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