Chiasma (Israel), LTD Company Profile

15:35 EDT 18th March 2018 | BioPortfolio

Chiasma develops new drug products based on its proprietary Transient Permeability Enhancer (TPE) technology, which enables oral delivery of macromolecules (up-to 20 kDa) and poorly-absorbed small molecules into the GI wall, portal system and then to the systemic circulation. Chiasma creates its internal pipeline by selecting approved macromolecules that are currently available in injectable form, changing the route of administration to oral and evaluating them for new indications, thereby creating new drugs that will take advantage of the 505(b)(2) regulatory route in the US and similar regulations in other countries.

Chiasma’s lead candidate, Octreolin™, is a product in capsule form (administered orally) that contains octreotide acetate, a 1.0 kDa peptide in the TPE formulation. Octreolin has successfully completed a Phase I clinical study evaluating its safety and pharmacokinetics (PK). Octreolin demonstrated a PK profile similar to that of subcutaneously injected octreotide acetate. In addition, no serious adverse safety events were reported. Chiasma intends to begin a pivotal trial by the end of 2010 for acromegaly, a hormonal disorder that results from an excess of growth hormone (GH). The pool of patients eligible for Octreolin treatment is estimated to be between 10,000 and 15,000 in the US and an equal number in Europe.

Octreolin is also being developed as an oral treatment for patients with Portal Hypertension (PHT); no drugs are approved for PHT in the US. A Phase 2 trial for this new indication is expected to start in December of 2010.

The Company is also developing: (1) An oral peptide (switch from injectable) for a new CNS indication; and (2) An oral protein (switch from injectable) for a viral disease that may also result in improvements to the label.


POB 45182
10 Hartom Street


Phone: 972-2-571-5885
Fax: 972-2-571-5886

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Chiasma (Israel), LTD

Chiasma develops new drug products based on its proprietary Transient Permeability Enhancer (TPE) technology, which enables oral delivery of macromolecules (up-to 20 kDa) and poorly-absorbed small mol...

Chiasma, Inc.

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