ChondroGene Limited Company Profile

12:30 EDT 23rd March 2018 | BioPortfolio

ChondroGene was formed in 1998 with the bringing together of its two key founders; Dr. K. Wayne Marshall, a noted orthopaedic surgeon and knee specialist and Dr. C.C. Liew, an internationally recognized leader in the area of tissue-specific functional genomics. Their respective expertise was combined to focus on developing new drugs and tests for osteoarthritis (OA), a chronic condition which affects the joints of millions of individuals worldwide, resulting in diminished quality of life for patients and severe economic burdens on healthcare systems.
The Company initially focussed on the use of functional genomics to characterize the molecular activity in tissues that make up the joints in the human body - cartilage, synovium and synovial fluid. The goal was to examine how the tissues of the joint function in different stages of osteoarthritis; from normal joints, to moderately diseased joints, all the way to severe osteoarthritis which could only be treated by total joint replacement. This work culminated in 2001 with the substantial completion of the identification and characterization of the chondrocyte genome (genes expressed in healthy and diseased human cartilage cells). The Company then produced the first known cDNA microarray specifically targeted at human cartilage gene expression, the ChondroChip™, an important platform tool that the Company is using to advance its research efforts in osteoarthritis. At the same time, the Company has applied the Sentinel Principle, a blood-based biomarker approach originally developed by Dr. Liew, to measure RNA expression in blood that can be used to detect and diagnose a variety of diseases and medical conditions throughout the body.


800 Petrolia Road, Unit 15
M3J 3K4


Phone: 416-650-0060
Fax: 416-650-0055

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Arthritis is by definition the inflammation of one or more joints, characterized by swelling, pain, warmth, redness and diminished range of joint movement (Oxford Medical Dictionary). There are many different types; Noninflammatory; Osteoarthritis, N...

Health care (or healthcare) is the diagnosis, treatment, and prevention of disease, illness, injury, and other physical and mental impairments in humans. Health care is delivered by practitioners in medicine, chiropractic, dentistry, nursing, pharmacy, a...

Arthritis Fibromyalgia Gout Lupus Rheumatic Rheumatology is the medical specialty concerned with the diagnosis and management of disease involving joints, tendons, muscles, ligaments and associated structures (Oxford Medical Diction...

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