Direct Therapeutics, Inc. Company Profile

11:56 EST 18th December 2018 | BioPortfolio

Direct Therapeutics, Inc. is a development-stage pharmaceutical company using its patented Solvent-Facilitated Perfusion technology to create new drugs for the localized and regional treatment of solid-tumor cancers. Our products are designed for direct injection to target tissue with minimal invasion of healthy tissue. They contain active ingredients in organic solvent vehicles that facilitate the penetration of the drug throughout tumor tissue and into tumor cells. In contrast to "sustained release" or "controlled release" products, our products rapidly, selectively, and thoroughly saturate tumors with doses of potent chemotherapeutic agents unachievable by other means. We have demonstrated that these products, when directly applied by needle or catheter to solid tumors, perfuse preferentially throughout the tumor, leading to rapid, selective death of cancerous tissue.
We have completed two Phase I/II studies of our lead product, DTI-015 in the United States for the treatment of brain cancer, and will start our first European trial of DTI-015 in Q1 2003. In November 2002 , we received notice from the US FDA that the company had satisfied the necessary requirements to initiate a Phase III product-registration trial of DTI-015 in patients with glioblastoma multiforme, the most common and deadly form of brain cancer. In addition, we are pursuing development of new Solvent-Facilitated Perfusion products, which have shown positive results in pre-clinical studies.


460 Seaport Court, Suite 220
United States of America



News Articles [1443 Associated News Articles listed on BioPortfolio]

Recurrence of HCC Following Direct-acting Antiviral Therapy

Might direct-acting antivirals increase risk and aggressiveness of hepatocellular carcinoma recurrence? This review aimed to characterize HCC recurrence patterns after DAA therapy. Alimentary Pharma...

Arch Therapeutics, Inc. $4.5 Million Registered Direct Offering

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VBL Therapeutics Announces Closing of $15.5 Million Registered Direct Offering

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Pain Therapeutics Announces Closing of $11.3 Million Registered Direct Offering

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VBL Therapeutics Announces $15.5 Million Registered Direct Offering Priced At-the-Market

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Pain Therapeutics Announces $11.3 Million Registered Direct Offering Priced At-the-Market

AUSTIN, Texas, Aug. 16, 2018 (GLOBE NEWSWIRE) -- Pain Therapeutics, Inc. (Nasdaq: PTIE), a biopharmaceutical company, today announced that it has entered into definitive agreements with several ins...

Adaptimmune Therapeutics plc Announces Closing of Registered Direct Offering of American Depositary Shares

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Aclaris Therapeutics Launches Direct-to-Consumer Campaign for ESKATA® (hydrogen peroxide) Topical Solution 40%, (w/w)

ESKATA is the First and Only FDA-Approved Topical Treatment for Raised Seborrheic Keratoses WAYNE, Pa., Oct. 01, 2018 (GLOBE NEWSWIRE) -- Aclaris Therapeutics, Inc. (NASDAQ:ACRS), a dermatologis...

PubMed Articles [1029 Associated PubMed Articles listed on BioPortfolio]

Interaction Between Direct Factor Xa Inhibitors and Digoxin.

Bioavailability of protein therapeutics in rats following inhalation exposure: Relevance to occupational exposure limit calculations.

Protein therapeutics represent a rapidly growing proportion of new medicines being developed by the pharmaceutical industry. As with any new drug, an Occupational Exposure Limit (OEL) should be develo...

Targeting Central Nervous System pathologies with nanomedicines.

One of the major challenges in drug development is the delivery of therapeutics to the central nervous system (CNS). The blood-brain barrier (BBB), which modulates the passage of molecules from the CN...

RNA Therapeutics (Almost) Comes of Age: Targeting, Delivery and Endosomal Escape.

RNA-targeted therapeutics for lipid disorders.

To summarize recent developments in the field of RNA-directed therapeutics targeting lipid disorders that are not effectively managed.

Clinical Trials [1564 Associated Clinical Trials listed on BioPortfolio]

Impact of Ibis on Patients With Advanced COPD

The purpose of this research is to determine if Ibis™, a digital therapeutics solution developed by Senscio Systems, reduces the emergency room visits and hospitalizations of patients wi...

HDL Acute Lipid Optimization in Homozygous Familial Hypercholesterolemia

Assess the effect on coronary atheroma of serial infusions of autologous selectively delipidated HDL/preβ enriched plasma following use of HDL Therapeutics PDS-2™ System

Ontogenesis of the P-Glycoprotein in Human Lymphocytes Influence of HIV and Antiretroviral Therapeutics

The P-glycoprotein (P-gp) is a membranous transporter that modulates the intracellular concentrations of many drugs and plays thus a major role in the efficacy of the therapeutics that act...

A Trial to Find Safe and Active Doses of an Investigational Drug CX-072 for Patients With Solid Tumors or Lymphomas

The purpose of this first-in-human study of CX-072 is to characterize the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and antitumor activity of CX-072 administered i...

Direct Anterior Approach Versus Direct Lateral Approach in Total Hip Arthroplasty

The purpose of this study is to compare the direct anterior approach and the direct lateral approach in primary total hip arthroplasty, regarding the postoperative function and pain, compl...

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