Dendritic NanoTechnologies Inc Company Profile

06:56 EDT 17th March 2018 | BioPortfolio

Dendritic NanoTechnologies Inc. (DNT) is the world’s leading developer and provider of advanced dendritic polymers. DNT has breakthrough technology that provides the vehicle — the targeting and delivery mechanisms — for a vast array of diagnostics and therapeutics currently in development in the biotechnology and pharmaceutical industries.DNT is a U.S. company incorporated in 2003 and located in Mount Pleasant, Michigan on the campus of Central Michigan University (CMU). DNT is developing and commercializing dendrimers — a type of polymer. These new types of nanostructures (particles so small they allow us to build new structures, literally, atom-by-atom) hold great promise for real-world applications, such as biotechnology and pharmaceuticals. DNT's business strategies are based on a broad technology platform advanced by DNT's founder, Donald A. Tomalia, Ph.D. from his initial discovery of dendrimers in 1979.


2625 Denison Drive
Mount Pleasant
United States of America


Phone: (989) 774-4199
Fax: (989) 774-2322

News Articles [47 Associated News Articles listed on BioPortfolio]

Boosting cancer therapy with refined dendritic vaccines

Researchers and physicians are looking into ways of increasing the precision and strength of the immune attack on a tumour. One approach is the "dendritic cell vaccine". Dendritic cells are speciali...

Personalized Dendritic Cell Vaccines Could Improve Cancer Immunotherapy

Dendritic cell vaccines, a promising cancer immunotherapy approach, usually come from dendritic cells that have been force-fed with tumor antigens. Dendritic cells, however, can also be modified so th...

Mechanism identified of impaired dendritic cell function that weakens response to cancer

(The Wistar Institute) Wistar scientists revealed the mechanism implicated in the defective function of tumor-associated dendritic cells (DCs), a specialized type of immune cells that expose the antig...

Enhanced IFN-α production is associated with increased TLR7 retention in the lysosomes of palasmacytoid dendritic cells in systemic lupus erythematosus

Interferon-α (IFN-α) is increased and plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). Plasmacytoid dendritic cells (pDCs) are the main producer of IFN-α, but thei...

Phase II Clinical Trial of Intratumoral Dendritic Cells Injections and Neoadjuvant Radiotherapy in Resectable Soft Tissue Sarcomas

Neoadjuvant radiation with dendritic cell injections has the potential to be safe, effective, and immunogenic in high-grade soft tissue sarcoma and needs to be confirmed in randomized larger clinical ...


• New research indicates that the role of dendritic cells in kidney inflammation is more complex than previously thought. Different types of dendritic cells communicate with each other to control th...

Order in disorder: A key feature of dendritic organization in the brain

(Max Planck Florida Institute for Neuroscience) Fitzpatrick and colleagues find that synaptic inputs in the visual cortex are locally -- but not globally -- organized. This local functional synaptic c...

Location, location, location: Immunization delivery site matters

(Jackson Laboratory) In vaccination, a certain subpopulation of dendritic cells is vital to triggering the body's adaptive immune system, report researchers at the Jackson Laboratory, Yale University ...

Drugs and Medications [9 Associated Drugs and Medications listed on BioPortfolio]

Viroptic [Monarch Pharmaceuticals, Inc]

VIROPTIC Ophthalmic Solution, 1% Sterile(trifluridine ophthalmic solution)

Zirgan [Bausch & Lomb Incorporated]

These highlights do not include all the information needed to use ZIRGAN safely and effectively. See full prescribing information for ZIRGAN.ZIRGAN (ganciclovir ophthalmic gel) 0.15%Initial U.S. Appro...

Trifluridine [Falcon Pharmaceuticals, Ltd.]


Statrol®neomycin and polymyxin bsulfates ophthalmic ointment, usp [ALCON LABORATORIES, INC.]

Statrol®neomycin and polymyxin Bsulfates ophthalmic ointment, USP

Statrol®neomycin and polymyxin bsulfates ophthalmic solution, usp [Alcon]

Statrol®neomycin and polymyxin Bsulfates ophthalmic solution, USP

PubMed Articles [376 Associated PubMed Articles listed on BioPortfolio]

Drebrin and Spine Formation.

Dendritic spines are the postsynaptic receptive regions of most excitatory synapses in the central nervous system. Thus, spines are supposed to act as a fundamental unit for information processing of ...

Phosphorylation and SUMOylation of CRMP2 regulate the formation and maturation of dendritic spines.

The posttranslational modifications of CRMP2 play an important role in axon outgrowth, cell polarization and dendritic morphogenesis. However, whether CRMP2 and its posttranslational modifications are...

Plasmacytoid dendritic cells: important players in human kidney allograft rejection.

Plasmacytoid dendritic cells are a unique dendritic cell subset that bridges innate and adaptive immune responses. They release high amounts of type I interferons in response to viral and bacterial in...

Non-neoplastic histiocytic and dendritic cell disorders in lymph nodes.

Benign and malignant proliferations of histiocytes and dendritic cells may be encountered in lymph nodes. Reactive histiocytic and dendritic cell infiltrates occur in response to diverse stimuli and i...

Input-dependent regulation of excitability controls dendritic maturation in somatosensory thalamocortical neurons.

Input from the sensory organs is required to pattern neurons into topographical maps during development. Dendritic complexity critically determines this patterning process; yet, how signals from the p...

Clinical Trials [312 Associated Clinical Trials listed on BioPortfolio]

Tumor Lysate Pulsed Dendritic Cell Immunotherapy for Patients With Brain Tumors

This research is being determine whether vaccinations with your own immune cells called " dendritic cells " can activate your immune system to fight your brain tumor.

Dendritic Cell Vaccine Study (DC/PC3) for Prostate Cancer

The purpose of this study is to assess the safety and activity of DC/PC3, a dendritic cell vaccine used as immunotherapy for prostate cancer. The vaccine is made with each participants' o...

A Pilot Study of Immunization With HIV-1 Antigen Pulsed Allogenic Dendritic Cells in HIV-Infected Asymptomatic Patients With CD4+ T Cells > 350 Cells/mm3

To define the safety and efficacy of sibling-supplied, HIV antigen-pulsed dendritic cells in increasing the immune response in HIV-infected patients. Dendritic cells are a type of white b...

Alpha-Type 1 Dendritic Cell (DC)-Based Vaccines Loaded With Allogeneic Prostate Cell Lines in Combination With Androgen Ablation in Patients With Prostate Cancer

Dendritic cells or "DCs" are special white blood cells that stimulate the immune system. This study is being done to test the feasibility, safety and efficacy of a specific type of dendrit...

Phase II Feasibility Study of Dendritic Cell Vaccination for Newly Diagnosed Glioblastoma Multiforme

Adult patients who have surgical resection of newly diagnosed glioblastoma multiforme will be treated with radiotherapy/chemotherapy followed by dendritic cell vaccine. Chemotherapy will ...

Companies [30 Associated Companies listed on BioPortfolio]

Dendritic NanoTechnologies Inc

Dendritic NanoTechnologies Inc. (DNT) is the world’s leading developer and provider of advanced dendritic polymers. DNT has breakthrough technology that provides the vehicle — the targeting and de...

BioTime, Inc. and Asterias Biotherapeutics, Inc.

Asterias Biotherapeutics, Inc. is a leading biotechnology company in the emerging field of regenerative medicine. The company’s proprietary, industry leading platforms are ba...


DCPrime develops off-the-shelf dendritic cell-based vaccines for a broad range of cancer types, based on its unique, proprietary technology platform, DCOne™. DCOne-based dend...

MagForce Nanotechnologies AG

MagForce Nanotechnologies AG is a world-leading company in the area of nanotechnology-based cancer treatment. Its patented Nano-Cancer® therapy enables the targeted destruction...

The Project on Emerging Nanotechnologies

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A diagnostic test is any kind of medical test performed to aid in the diagnosis or detection of disease. For example: to diagnose diseases to measure the progress or recovery from disease to confirm that a person is free from disease Clin...

Antibodies Antisense Assays Biochips Bioinformatics Biological Therapy Biomarkers Biomaterials Bioscience Cell Culture Cloning Cytokine Diagnostics Dna Extraction Dna Sequencing Dna Transform...

Biotechnology - Biotech
"using living things to create products or to do tasks for humans" About Biotechnology - Biotech Biotechnology is the practice of using plants, animals and micro-organisms such as bacteria, as well as biological processes - such as the ripen...

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