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Endocyte Company Profile

16:41 EDT 25th September 2018 | BioPortfolio

Endocyte is developing a new generation of receptor-targeted therapeutics or "smart drugs" for the treatment of cancer and autoimmune diseases. Current non-targeted drugs are usually toxic to normal healthy cells causing serious side effects. These side effects can be life-threatening which leads to suboptimal dosing. Receptor-targeted therapeutics can be more effective because they can be targeted with lethal precision to high affinity receptors over-expressed by diseased cells. Our initial focus is on a receptor for the vitamin folic acid, which is often over-expressed on cancer cells. By attaching drugs to folic acid, the vitamin acts like a “Trojan Horse” to target and deliver drugs to cancer cells, which could allow higher and more effective doses to be given with reduced side effects. 1988-1996
Researchers in Dr. Philip Low’s laboratory at Purdue University discover a new entry pathway for vitamins into plant cells and demonstrate that proteins can be delivered into plant cells via this pathway if they are first attached to the vitamins (initial discovery published in Plant Physiology).

Researchers in Dr. Low’s laboratory observe that proteins can also be delivered into cultured animal cells by piggybacking the proteins on to vitamins. Discovery of folate-targeting was made by Philip Low and Chris Leamon in 1989 (initial discovery published in Proceedings of National Academy of Sciences).

Research from other labs demonstrates that the uptake pathway for folic acid is primarily present in cancer cells, allowing Endocyte’s future use of folic acid as a Trojan horse to target folate-linked drugs specifically to cancer cells.

Location

3000 Kent AvenueSuite A1-100
West Lafayette
Indiana
47906
United States of America

Contact

Phone: 765.463.7175
Fax: 765.463.9271
Email: information@endocyte.com


News Articles [46 Associated News Articles listed on BioPortfolio]

Endocyte expands supply deal for VISION prostate cancer trial

A German specialist will produce the clinical and commercial supply of a radioactive isotope needed for Endocyte's therapy.

Endocyte Updates Phase III Trial Design, Sells $175 Million in Stock

Shares of Indiana-based Endocyte have slipped more than 3 percent this morning after the company announced the U.S. Food and Drug Administration accepted radiographic progression-free survival as an a...

Endocyte nets $81mm through public offering

Endocyte Inc. netted $81mm through a public offering of 20.5mm common shares (including the overallotment) at $4.20. The company is developing targeted cancer therapies, and will use the proceeds to a...

Public offering nets $164.5mm for Endocyte

Endocyte Inc. (targeted cancer therapies and companion imaging agents) netted $164.5mm through the public sale of 9.5mm common shares at $18.50. Proceeds will support continued pipeline development an...

Public offering nets $189mm for Endocyte

Endocyte Inc. (targeted cancer therapies and companion imaging agents) netted $189mm through the public sale of 10.9mm common shares (including the overallotment) at $18.50. Proceeds will support cont...

Endocyte and ITM Announce Long-Term Supply Agreement for No-Carrier-Added Lutetium-177

Strategic Partnership supports Commercialization beyond ongoing Phase 3 VISION Trial of 177Lu-PSMA-617 Endocyte, Inc. (Nasdaq:ECYT), and ITM Isotopen Technologien München AG ...

Endocyte raises $175M

Endocyte Is A Solid Buy Opportunity For 2018

Drugs and Medications [0 Results]

None

PubMed Articles [0 Results]

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Clinical Trials [1 Associated Clinical Trials listed on BioPortfolio]

Extension Study of EC145 for Subjects Enrolled in a Previous Study With EC145

This extension protocol is for those subjects that have completed the allowed duration of participation in an Endocyte-sponsored clinical trial of EC145 and have continuing evidence of cli...

Companies [4 Associated Companies listed on BioPortfolio]

Endocyte Incorporated

Endocyte, Inc is a biotechnology company focused on vitamin based drug targeting and delivery systems. Vitamins are essential components for specific biological cellular functions. Endocyte's mission ...

Endocyte, Inc.

Endocyte is a privately held biotechnology company with headquarters in the Purdue Research Park of West Lafayette, IN. Based on the applications of Endocyte’s advanced propr...

Endocyte

Endocyte is developing a new generation of receptor-targeted therapeutics or "smart drugs" for the treatment of cancer and autoimmune diseases. Current non-targeted drugs are usually toxic to normal h...

Merck and Endocyte

Today’s Merck is a global healthcare leader working to help the world be well. Merck is known as MSD outside the United States and Canada. Through our prescription medicines,...

More Information about "Endocyte" on BioPortfolio

We have published hundreds of Endocyte news stories on BioPortfolio along with dozens of Endocyte Clinical Trials and PubMed Articles about Endocyte for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Endocyte Companies in our database. You can also find out about relevant Endocyte Drugs and Medications on this site too.

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