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F2G Ltd Company Profile

03:01 EST 12th December 2018 | BioPortfolio

F2G is advancing its own patented compounds and technologies which will lead to the development of novel agents to treat serious fungal disease.
The Company was founded on its proprietary genomics technology (MycoBank®) that identifies essential gene targets in fungi. Having received initial funding in 2002 the company then rapidly diversified into chemistry-driven discovery. We have also assembled an experienced development capacity. Our complementary approaches of robotic-based whole-cell-screens and enzyme-based high throughput screens assessing genes identified via MycoBank and using our diverse compound library of more than 360,000 compounds has delivered a portfolio of molecules into our drug development processes. Currently we have one series active against important moulds with preliminary evidence of activity in vivo and other chemical series active against a broader spectrum of fungi. Numerous essential fungal genes are also being assessed as targets for anti-fungal action. This progress has been delivered by our high-calibre staff using expertise in fungal molecular biology, biochemistry, clinical microbiology, animal pharmacology and medicinal chemistry. In late 2004 our Target Product Profiles were shared with an international panel of anti-fungal physicians who readily agreed that such compounds are needed by the infectious disease community; additional market research has established that new anti-fungal therapies are financially highly attractive. The F2G science team is supported by a management group which brings many years of experience from the world of finance and the Pharmaceutical Industry.

Location

PO Box 1Lankro Way
Eccles
Manchester
M30 0BH
United Kingdom

Contact

Phone: 44 (0)161 785 1270
Fax: 44 (0)161 785 1273
Email: contact@f2g.com


News Articles [445365 Results]

Aeglea BioTherapeutics Announces Positive Clinical Updates

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Pigment Epithelium Derived Factor: Characterization, Genomic Organization and Sequence of PEDF Gene

Retinal pigment epithelium (RPE) cells secrete a unique 50 kD protein. This protein, pigment epithelium-derived factor (PEDF), contains trophic activity in both the induction of neuronal cell differen...

Pigment Epithelium Derived Factor: Characterization of Its Novel Biological Activity and Sequences Encoding and Expressing the Protein

Pigment epithelium-derived factor (PEDF), a unique 50 kD protein secreted by retinal pigment epithelium (RPE) cells, has trophic activity. This invention describes the biological activity of PEDF, a m...

AAV4 Vector And Uses Thereof

These patent applications describe the cloning and characterization of the full-length genome of adeno-associated virus type 4 (AAV4). AAV4, like other members of the AAV family, may be useful as a ve...

Virally Mediated Gene Therapy For The Control Of Chronic Or Persistent Pain

Current treatments for pain, especially chronic pain, are only partially effective and can eventually involve procedures that are invasive or associated with unacceptable side effects. In vivo gene tr...

Method of Diagnosing Multidrug Resistant Tuberculosis

The invention can be used to develop tests that are much more rapid than conventional tests for determining drug resistance. It relates to the discovery that a putative gene of Mycobacterium tuberculo...

Ocular Therapeutic Agent Delivery Devices And Methods

The invention is directed to ocular implant devices for the delivery of therapeutic agents to the eye in a controlled and sustained manner. Implants suitable for either subconjunctival or intravitrea...

Parallel Measurements of Multiple Macromolecules Using a Cryoarray

Available for license is a new improved technique for the creation of biological arrays of 25-100 biological samples per slide, for use in parallel molecular screening in medical research and clinical...

PubMed Articles [1002839 Results]

Effects of proinsulin misfolding on β-cell dynamics, differentiation and function in diabetes.

ER stress due to proinsulin misfolding has an important role in the pathophysiology of rare forms of permanent neonatal diabetes (PNDM) and probably also of common type 1 (T1D) and type 2 diabetes (T2...

Regulation of islet glucagon secretion: Beyond calcium.

The islet of Langerhans plays a key role in glucose homeostasis through regulated secretion of the hormones insulin and glucagon. Islet research has focused on the insulin-secreting β-cells, even tho...

Biosynthesis, structure, and folding of the insulin precursor protein.

Insulin synthesis in pancreatic β-cells is initiated as preproinsulin. Prevailing glucose concentrations, which oscillate pre- and postprandially, exert major dynamic variation in preproinsulin biosy...

Role of ghrelin in pancreatic development and function.

Ghrelin is a gastric peptide with anabolic functions. It acutely stimulates growth hormone (GH) secretion from the anterior pituitary glands and modulates hypothalamic circuits that control food intak...

Lysosomes in nutrient signalling: A focus on pancreatic β-cells.

Regulated insulin secretion from pancreatic β-cells is a major process maintaining glucose homeostasis in mammals. Enhancing insulin release in response to chronic nutrient overload and obesity-relat...

Clinical Trials [163276 Results]

The Utility of Peri-operative Arnica Montana for Reduction of Ecchymosis in Rhinoplasty Surgery

Arnica montana is a homeopathic drug that is made in accordance with the official methods of the Homeopathic Pharmacopoeia of the United States (HPUS) and is commonly used by cosmetic surg...

Pharyngeal Size in Patients With Obstructive Tonsils Under Orthodontic Treatment

Enlarged tonsils and malocclusion has relationship with sleep disturbance in children. The consequences of these features can include aggravation of craniofacial growth such that the devel...

The Biology of Chronic Preconditioning: Genomic and Physiologic Mechanisms of Response

The purpose of this study is to assess the effects of repeated RIPC and exercise, on exercise performance, skeletal muscle responses and circulating cellular and humoral biology in humans

Pilot Study of Raltegravir Lipodystrophy IISP

The substitution of raltegravir for the NRTIs will result in some reversal of the long term adverse effect of lipodystrophy (specifically peripheral lipoatrophy) that is associated with th...

Esophagoscopy in Evaluating Treatment in Patients With Stage I-IV Head and Neck Cancer Who Are Undergoing Radiation Therapy and/or Chemotherapy

Brief Summary: RATIONALE: Comparing results of diagnostic procedures, such as esophagoscopy, done before and after radiation therapy and/or chemotherapy may help doctors predict a patient...

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More Information about "F2G Ltd" on BioPortfolio

We have published hundreds of F2G Ltd news stories on BioPortfolio along with dozens of F2G Ltd Clinical Trials and PubMed Articles about F2G Ltd for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of F2G Ltd Companies in our database. You can also find out about relevant F2G Ltd Drugs and Medications on this site too.

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