Gene Tools LLC Company Profile

11:04 EST 15th December 2018 | BioPortfolio

Gene Tools is the sole commercial supplier for research quantities of Morpholino antisense oligos world-wide. Our Morpholino oligos are the premier tools for gene knockdown in developmental biology labs and are the best gene-silencing reagents for cells in culture. Morpholino oligos are short chains of Morpholino subunits comprised of a nucleic acid base, a morpholine ring and a non-ionic phosphorodiamidate intersubunit linkage. Morpholinos act via a steric block mechanism (RNAse H-independent) and with their high mRNA binding affinity and exquisite specificity they yield reliable and predictable results. They either can block translation initiation in the cytosol (by targeting the 5' UTR through the first 25 bases of coding sequence) or they can modify pre-mRNA splicing in the nucleus (by targeting splice junctions). We continually develop novel delivery systems like our 'Endo-Porter' and our soon-to-be launched in vivo delivery system, making it easy to deliver Morpholinos into cultured cells and soon into animals -- making Morpholinos the best tools for genetic studies and drug target validation programs


One Summerton Way
United States of America


Phone: (541) 929-7840
Fax: (541) 929-7841

News Articles [1526 Associated News Articles listed on BioPortfolio]

Researchers examine immune responses to CRISPR-Cas9 gene editing system

The CRISPR-Cas9 gene editing system has been generating excitement within the field of gene therapy, inspiring hopes of molecular tools capable of treating genetic diseases.

Analytical Tools Reveal Molecular Mechanism of Gene-Editing Tool

A recent paper described the use of advanced analytical techniques to define the mode of action of the gene-editing tool...

NYU's Sanjana receives DARPA 2018 Young Faculty Award for precise gene repair

(New York University) NYU biologist Neville Sanjana has received the Defense Advanced Research Projects Agency's 2018 Young Faculty Award for his proposal to develop new tools for precise gene repair ...

Researchers Discover CRISPR/Cas9 Gene Editing Tools Could Cause Unforeseen Mutations

ArticleOne of the first in-depth looks into the impact of CRISPR/Cas9 is raising questions regarding the safety of the gene editing tool.

J.R. Simplot enters deal on CRISPR, gene-editing tools

J.R.  -More- 

UMD's Juntti awarded grant to design tools linking gene changes to traits in cichlid fish

(University of Maryland) Scott Juntti, the William J. Higgins Assistant Professor of Biology at the University of Maryland, received one of 11 new awards from the National Science Foundation's Enablin...

Medical News Today: Gene editing for cancer prevention may actually cause cancer

Gene editing tools have been hailed as promising in cancer prevention therapy. However, new research warns that they may, in fact, help to trigger cancer.

Gene Therapy Guidance From US FDA Likely Needs Updating Sooner Rather Than Later

CBER Director Peter Marks says the "half-life" for the existing six gene therapy guidances likely is two to three years due...   

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RETIN-A MICRO® (tretinoin gel) microsphere, 0.1% and 0.04%

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PubMed Articles [2289 Associated PubMed Articles listed on BioPortfolio]

Molecular biology tools for the study and therapy of PDE6β mutations.

Gene therapy has the potential for treating retinal diseases, and we have been developing delivery vehicles and expression vectors for this purpose. In this short communication, we describe the genera...

Riboregulator elements as tools to engineer gene expression in cyanobacteria.

Cyanobacteria are an ideal host for biofuel production. Although efforts have been made to genetically engineer cyanobacteria for efficient production of biofuels and other important chemicals, the to...

TAPAS: tool for alternative polyadenylation site analysis.

The length of the 3' untranslated region (3' UTR) of an mRNA is essential for many biological activities such as mRNA stability, sub-cellular localization, protein translation, protein binding and tra...

Gene-specific metrics to facilitate identification of disease genes for molecular diagnosis in patient genomes: a systematic review.

The evolution of next-generation sequencing technologies has facilitated the detection of causal genetic variants in diseases previously undiagnosed at a molecular level. However, in genome sequencing...

The GFF3toolkit: QC and Merge Pipeline for Genome Annotation.

The GFF3toolkit ( ) supported by the i5k Workspace@NAL provides a suite of tools to handle gene annotations in GFF3 format from arthropod genome projects and the...

Clinical Trials [2783 Associated Clinical Trials listed on BioPortfolio]

CMV Disease and IRIS in HIV-1 Infected Persons

Various diagnostic methods are available for CMV infection. But none of them could be a standard and highly valuable. Our first goal is to setup a series of molecular diagnostic tools for ...

LTFU for Gene Transfer Subjects With Hemophilia B

Several subjects enrolled in a multi-site, gene transfer clinical study to evaluate the intrahepatic administration of AAV2-hFIX16 vector for the treatment of severe hemophilia B between 2...

IMPACCT for Kids' Care

Health insurance is important for children. Public insurance programs are available to many children, but some families report being confused about how to get and keep this insurance. Comm...

Genomic Structural Variation in Cancer Susceptibility

This study will look for new types of gene changes that may be related to cancer in some patients. Some gene changes (mutations) are passed on from parents to offspring (child). Other gene...

Lentiviral Gene Therapy for X-ALD

This is a Phase I/II clinical trial of gene therapy for treating X-linked adrenoleukodystrophy using a high-safety, high-efficiency, self-inactivating lentiviral vector TYF-ABCD1 to functi...

Companies [1362 Associated Companies listed on BioPortfolio]

Gene Tools LLC

Gene Tools is the sole commercial supplier for research quantities of Morpholino antisense oligos world-wide. Our Morpholino oligos are the premier tools for gene knockdown in developmental biology la...

Enzo Life Sciences Inc.

Enzo Biochem, Inc. is a leading life sciences and biotechnology company focused on harnessing genetic processes to develop research tools, diagnostics and therapeutics and providing reference laborato...

Welgen Incorporation

Welgen, Inc. was founded in 2002 to provide the fastest, most reliable technology available for the construction of recombinant adenoviruses and other research tools. We are currently located in a fac...

Sirion GmbH

SIRION offers tools and services for RNAi expression and solutions for customized adenovirus-mediated gene delivery. SIRIONs proprietary Q-tech technology enables efficient RNAi driven gene silencing ...


INHERINET (Gene Therapy of Hematopoietic Stem Cells for Inherited Diseases), an initiative founded by seven European research institutions, accumulates the expertise of biomedical scientists who have ...

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Relevant Topics

Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...

Antisense therapy
Most human diseases are caused by production of abnormal proteins or malfunctioning proteins.   Antisense therapy involves inhibiting production of these proteins.  When a gene is known to cause a specific disease and the genetic sequence ...

Drug Discovery
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...

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