Gene Tools LLC Company Profile

00:44 EST 22nd November 2017 | BioPortfolio

Gene Tools is the sole commercial supplier for research quantities of Morpholino antisense oligos world-wide. Our Morpholino oligos are the premier tools for gene knockdown in developmental biology labs and are the best gene-silencing reagents for cells in culture. Morpholino oligos are short chains of Morpholino subunits comprised of a nucleic acid base, a morpholine ring and a non-ionic phosphorodiamidate intersubunit linkage. Morpholinos act via a steric block mechanism (RNAse H-independent) and with their high mRNA binding affinity and exquisite specificity they yield reliable and predictable results. They either can block translation initiation in the cytosol (by targeting the 5' UTR through the first 25 bases of coding sequence) or they can modify pre-mRNA splicing in the nucleus (by targeting splice junctions). We continually develop novel delivery systems like our 'Endo-Porter' and our soon-to-be launched in vivo delivery system, making it easy to deliver Morpholinos into cultured cells and soon into animals -- making Morpholinos the best tools for genetic studies and drug target validation programs


One Summerton Way
United States of America


Phone: (541) 929-7840
Fax: (541) 929-7841

News Articles [1369 Associated News Articles listed on BioPortfolio]

A Human Being Has Been Injected with Gene-Editing Tools to Cure His Disabling Disease. Here’s What You Need to Know

(Science) – For the first time, researchers have infused a person’s blood with gene-editing tools, aiming to treat his severe inherited disease, The Associated Press (AP) reported today. The 4...

A human has been injected with gene editing tools to cure his disabling disease. Here’s what you need to know – Science Magazine

Science MagazineA human has been injected with gene editing tools to cure his disabling disease. Here's what you need to knowScience MagazineFor the first time, researchers have infused a person's blo...

Power Up! CRISPRi & CRISPRa Tools for Genome-Wide Screening

Horizon Discovery is leveraging these technologies to address novel research questions and deliver insights into essential gene function, hypomorphic expression, and gene dominance.

Like a cut-and-paste tool, CRISPR is transforming gene-editing research – The Indian Express

The Indian ExpressLike a cut-and-paste tool, CRISPR is transforming gene-editing researchThe Indian ExpressNew gene editing tools let scientists alter the DNA of living cells - from plants, animals, e...

Medical first: Doctors attempt to gene-edit a living patient’s DNA – CNN

CNNMedical first: Doctors attempt to gene-edit a living patient's DNACNN(CNN) A man may soon be forever free of the previously incurable disease he was born with 44 years ago. On Monday, in a medical ...

Direct evidence of the GC-NSF(a) hypothesis on creation of an entirely new gene/protein

(Bentham Science Publishers) The hypothesis assumes that an entirely new gene is produced from the non-stop frame on the antisense strand of a GC-rich gene after gene duplication, followed by the accu...

Gene editing within a living person for the first time

Genetic editing has been performed in the laboratory until now. Living cells within Petri-dishes have been put under the microscope while gene editing tools such as CRISPR were used to cut, nick and r...

RNA editing tools could create new disease therapies

A new molecular tool to change individual letters in an RNA sequence may open up new possibilities for gene therapy...

Drugs and Medications [5 Associated Drugs and Medications listed on BioPortfolio]

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R-Gene 10Arginine Hydrochloride Injection, USP

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RETIN-A MICRO® (tretinoin gel) microsphere, 0.1% and 0.04%

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RETIN-A MICRO® (tretinoin gel) microsphere, 0.1% and 0.04%

Easy care first aid [Tender Corp dba Adventure Medical Kits]


PubMed Articles [2350 Associated PubMed Articles listed on BioPortfolio]

Gene Drive for Mosquito Control: Where Did It Come from and Where Are We Headed?

Mosquito-borne pathogens place an enormous burden on human health. The existing toolkit is insufficient to support ongoing vector-control efforts towards meeting disease elimination and eradication go...

A critical assessment of topologically associating domain prediction tools.

Topologically associating domains (TADs) have been proposed to be the basic unit of chromosome folding and have been shown to play key roles in genome organization and gene regulation. Several differe...

Vectors and Gene Delivery to the Retina.

One of the great advantages of the retina as a target tissue for gene delivery is the wide array of genetic tools that have been developed in the past decade. This includes a variety of vectors for th...

A compilation of Web-based research tools for miRNA analysis.

Since the discovery of microRNAs (miRNAs), a class of noncoding RNAs that regulate the gene expression posttranscriptionally in sequence-specific manner, there has been a release of number of tools us...

Molecular tools for gene manipulation in filamentous fungi.

Functional genomics of filamentous fungi has gradually uncovered gene information for constructing 'cell factories' and controlling pathogens. Available gene manipulation methods of filamentous fungi ...

Clinical Trials [2212 Associated Clinical Trials listed on BioPortfolio]

CMV Disease and IRIS in HIV-1 Infected Persons

Various diagnostic methods are available for CMV infection. But none of them could be a standard and highly valuable. Our first goal is to setup a series of molecular diagnostic tools for ...

LTFU for Gene Transfer Subjects With Hemophilia B

Several subjects enrolled in a multi-site, gene transfer clinical study to evaluate the intrahepatic administration of AAV2-hFIX16 vector for the treatment of severe hemophilia B between 2...

IMPACCT for Kids' Care

Health insurance is important for children. Public insurance programs are available to many children, but some families report being confused about how to get and keep this insurance. Comm...

Genomic Structural Variation in Cancer Susceptibility

This study will look for new types of gene changes that may be related to cancer in some patients. Some gene changes (mutations) are passed on from parents to offspring (child). Other gene...

Gene Therapy in Treating Patients With Cancer of The Liver

RATIONALE: Inserting the p53 gene into a person's tumor may improve the body's ability to fight liver cancer. PURPOSE: Phase I trial to study the effectiveness of gene therapy with the p5...

Companies [1289 Associated Companies listed on BioPortfolio]

Gene Tools LLC

Gene Tools is the sole commercial supplier for research quantities of Morpholino antisense oligos world-wide. Our Morpholino oligos are the premier tools for gene knockdown in developmental biology la...

Enzo Life Sciences Inc.

Enzo Biochem, Inc. is a leading life sciences and biotechnology company focused on harnessing genetic processes to develop research tools, diagnostics and therapeutics and providing reference laborato...

Welgen Incorporation

Welgen, Inc. was founded in 2002 to provide the fastest, most reliable technology available for the construction of recombinant adenoviruses and other research tools. We are currently located in a fac...

Sirion GmbH

SIRION offers tools and services for RNAi expression and solutions for customized adenovirus-mediated gene delivery. SIRIONs proprietary Q-tech technology enables efficient RNAi driven gene silencing ...


INHERINET (Gene Therapy of Hematopoietic Stem Cells for Inherited Diseases), an initiative founded by seven European research institutions, accumulates the expertise of biomedical scientists who have ...

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Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...

Antisense therapy
Most human diseases are caused by production of abnormal proteins or malfunctioning proteins.   Antisense therapy involves inhibiting production of these proteins.  When a gene is known to cause a specific disease and the genetic sequence ...

Drug Discovery
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...

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