Gene Tools LLC Company Profile

05:40 EDT 18th June 2018 | BioPortfolio

Gene Tools is the sole commercial supplier for research quantities of Morpholino antisense oligos world-wide. Our Morpholino oligos are the premier tools for gene knockdown in developmental biology labs and are the best gene-silencing reagents for cells in culture. Morpholino oligos are short chains of Morpholino subunits comprised of a nucleic acid base, a morpholine ring and a non-ionic phosphorodiamidate intersubunit linkage. Morpholinos act via a steric block mechanism (RNAse H-independent) and with their high mRNA binding affinity and exquisite specificity they yield reliable and predictable results. They either can block translation initiation in the cytosol (by targeting the 5' UTR through the first 25 bases of coding sequence) or they can modify pre-mRNA splicing in the nucleus (by targeting splice junctions). We continually develop novel delivery systems like our 'Endo-Porter' and our soon-to-be launched in vivo delivery system, making it easy to deliver Morpholinos into cultured cells and soon into animals -- making Morpholinos the best tools for genetic studies and drug target validation programs


One Summerton Way
United States of America


Phone: (541) 929-7840
Fax: (541) 929-7841

News Articles [1449 Associated News Articles listed on BioPortfolio]

Scientists using gene editing to stop HIV from infecting cells

Numerous studies are underway to determine how gene therapy and the use of gene-editing tools can possibly cure HIV by using  -More- 

SMi presents the launch of Cell & Gene Therapy 2018

10 - 11 October, London, UK. SMi introduces their inaugural event on Cell & Gene Therapy which takes place between the 10th and 11th October 2018, with an interactive pre-conference workshop on the 9t...

Exploring the potential application of short non‐coding RNA‐based genetic circuits in Chinese Hamster Ovary cells

The majority of cell engineering for recombinant protein production to date has relied on traditional genetic engineering strategies, such as gene overexpression and gene knock‐outs, to substantiall...

NIH Commits $190M to Somatic Gene-Editing Tools/Tech Research

The NIH said it plans to award approximately $190 million over six years to researchers, starting this year, toward developing tools and technologies designed to enable safe and effective genome editi...

New and improved CRISPR

David Liu, professor of chemistry and chemical biology at Harvard University is a pioneer of CRISPR-Cas9 gene-editing technology. He has now come up with two new upgrades for this gene editing tool th...

Medical News Today: Gene editing for cancer prevention may actually cause cancer

Gene editing tools have been hailed as promising in cancer prevention therapy. However, new research warns that they may, in fact, help to trigger cancer.

Using dbSNP and ClinVar to Classify Gene Variants

As we discussed previously, the gaps in our understanding of the human genome make variant classification an extremely difficult job. However, with each passing day our knowledge increases, and the to...

Gene By Gene Selects BC Platforms to Enhance its World Leading Genomic Data Processing Services

Through its division, Family Tree DNA, Gene by Gene was the first company globally to develop DNA testing for ancestry and genealogical purposes as a Read more...

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PubMed Articles [2360 Associated PubMed Articles listed on BioPortfolio]

GNC-app: A new Cytoscape app to rate gene networks biological coherence using gene-gene indirect relationships.

Gene networks are currently considered a powerful tool to model biological processes in the Bioinformatics field. A number of approaches to infer gene networks and various software tools to handle the...

SPRING: a kinetic interface for visualizing high dimensional single-cell expression data.

Single-cell gene expression profiling technologies can map the cell states in a tissue or organism. As these technologies become more common, there is a need for computational tools to explore the dat...

AGORA : Organellar genome annotation from the amino acid and nucleotide references.

Next-generation sequencing (NGS) technologies have led to the accumulation of highthroughput sequence data from various organisms in biology. To apply gene annotation of organellar genomes for various...

Exploring the potential application of short non-coding RNA-based genetic circuits in Chinese Hamster Ovary cells.

The majority of cell engineering for recombinant protein production to date has relied on traditional genetic engineering strategies, such as gene overexpression and gene knock-outs, to substantially ...

Evaluation of tools for highly variable gene discovery from single-cell RNA-seq data.

Traditional RNA sequencing (RNA-seq) allows the detection of gene expression variations between two or more cell populations through differentially expressed gene (DEG) analysis. However, genes that c...

Clinical Trials [2494 Associated Clinical Trials listed on BioPortfolio]

CMV Disease and IRIS in HIV-1 Infected Persons

Various diagnostic methods are available for CMV infection. But none of them could be a standard and highly valuable. Our first goal is to setup a series of molecular diagnostic tools for ...

LTFU for Gene Transfer Subjects With Hemophilia B

Several subjects enrolled in a multi-site, gene transfer clinical study to evaluate the intrahepatic administration of AAV2-hFIX16 vector for the treatment of severe hemophilia B between 2...

IMPACCT for Kids' Care

Health insurance is important for children. Public insurance programs are available to many children, but some families report being confused about how to get and keep this insurance. Comm...

Genomic Structural Variation in Cancer Susceptibility

This study will look for new types of gene changes that may be related to cancer in some patients. Some gene changes (mutations) are passed on from parents to offspring (child). Other gene...

Gene Therapy in Treating Patients With Cancer of The Liver

RATIONALE: Inserting the p53 gene into a person's tumor may improve the body's ability to fight liver cancer. PURPOSE: Phase I trial to study the effectiveness of gene therapy with the p5...

Companies [1326 Associated Companies listed on BioPortfolio]

Gene Tools LLC

Gene Tools is the sole commercial supplier for research quantities of Morpholino antisense oligos world-wide. Our Morpholino oligos are the premier tools for gene knockdown in developmental biology la...

Enzo Life Sciences Inc.

Enzo Biochem, Inc. is a leading life sciences and biotechnology company focused on harnessing genetic processes to develop research tools, diagnostics and therapeutics and providing reference laborato...

Welgen Incorporation

Welgen, Inc. was founded in 2002 to provide the fastest, most reliable technology available for the construction of recombinant adenoviruses and other research tools. We are currently located in a fac...

Sirion GmbH

SIRION offers tools and services for RNAi expression and solutions for customized adenovirus-mediated gene delivery. SIRIONs proprietary Q-tech technology enables efficient RNAi driven gene silencing ...


INHERINET (Gene Therapy of Hematopoietic Stem Cells for Inherited Diseases), an initiative founded by seven European research institutions, accumulates the expertise of biomedical scientists who have ...

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Relevant Topics

Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...

Antisense therapy
Most human diseases are caused by production of abnormal proteins or malfunctioning proteins.   Antisense therapy involves inhibiting production of these proteins.  When a gene is known to cause a specific disease and the genetic sequence ...

Drug Discovery
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...

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