High Throughput Genomics, Inc Company Profile

10:06 EST 12th December 2018 | BioPortfolio

High Throughput Genomics (HTG) was founded to: Develop and market ArrayPlate measurement of gene expression, DNA and proteins.
Develop and market gene expression quantitative Nuclease Protection Assays (qNPA™).
Satisfy unmet needs encountered at all levels of drug discovery, clinical development, and clinical practice.
Other commercialized methods for drug discovery lack sensitivity and have poor reproducibility. As a result low and moderately expressed genes that change slightly but significantly in disease states cannot be identified accurately against background assay noise.
HTG introduced the ArrayPlate, its first qNPA product, to measure multiple gene expression targets simultaneously. The ArrayPlate combines the high sample throughput of traditional microplates with HTG's novel Universal Array™ technology, permitting investigators to customize the genes measured in each well using a simple bench-top[ reagent addition procedure, producing self-customized arrays. With the combination of these two technologies, researchers now have access to the excellent sensitivity required to detect small changes and weak activity and the reproducibility of conventional biochemical assays in a multiplexed format permitting the measurement of sets of from 2 to 128 or more genes for high volume profiling of gene expression. In practical terms, this combination provides sensitivity down to 1,000 cells on 0.01 micrograms of total RNA and exceptional reproducibility of 3% to 13% coefficient of variation (C.V.) across the entire assay for cellular in vitro and in vivo tissue assays. The ability to easily measure gene expression from fixed tissue with the same high quality as from cells or frozen tissue is unique to qNPA


6296 E. Grant Road
United States of America


Phone: (520) 547-2827
Fax: (520) 547-2837

News Articles [1034 Associated News Articles listed on BioPortfolio]

Creating an Automated High-Throughput Flow Cytometry System

NewsResearchers from the Genomics Institute of the Novartis Research Foundation highlights a diversity of approaches that their automated high-throughput flow cytometry has enabled for phenotypic drug...

Whole Animal Feeding Flat (WAFFL): A High-throughput Platform for the Automated Handling of Flies

Drosophila is well-suited organism to be use in high-throughput studies due to their short, defined life cycle and genetic tools. However, current high-throughput fly methodologies are not ideal. They...

Global High-throughput Satellite Market - Focus on Application (Broadband, Enterprise, ...

LONDON, Oct. 2, 2018 /PRNewswire/ -- Global High-throughput Satellite Market to Reach $7.31 Billion by 2023 The global high-throughput satellite market has exhibited a high Read more...

UTA, Texas A&M create Texas Genomics Core Alliance

(University of Texas at Arlington) Texas A&M University and The University of Texas at Arlington have established The Texas Genomics Core Alliance to increase access to and decrease costs of cutting-e...

Saarland University cooperates with leading Chinese genomics organization BGI

(Saarland University) In order to detect neurodegeneration in time and to pave the way for curing dementia in the future, scientists are exploring the potential of small non-coding RNAs, parts of the ...

NIHR whitepaper claims UK needs High Throughput Centres after Brexit

The National Institute for Health Research (NIHR) has released a new whitepaper outlining the substantial benefits NHS High Throughput Centres could bring to UK patients and the NHS. The policy paper ...

healthcare, bioinformatics, molecular evolution, chemoinformatics, antisense, tissue sealants

Provider,of,conferences, and, publications, on, combinatorial, chemistry, high, throughput, screening, bioinformatics, drug, discovery, and, genomics

high throughput screening, fluorescence polarization, analyst, immunoassay, microplates, well plates


Drugs and Medications [0 Results]


PubMed Articles [1789 Associated PubMed Articles listed on BioPortfolio]

Corrigendum: SeroBA: rapid high-throughput serotyping of Streptococcus pneumoniae from whole genome sequence data.

Comparative Analysis of Droplet-Based Ultra-High-Throughput Single-Cell RNA-Seq Systems.

Since its establishment in 2009, single-cell RNA sequencing (RNA-seq) has been a major driver behind progress in biomedical research. In developmental biology and stem cell studies, the ability to pro...

Chemical Genomics Translatability from Unicellular to Multicellular Models.

Chemical genomics has proven to be a useful and successful approach to study complex systems where conventional genetics fails to render feasible results. High-throughput phenotype screenings in model...

Nucleic acid-barcoding technologies: converting DNA sequencing into a broad-spectrum molecular counter.

The emergence of high-throughput DNA sequencing technologies sparked an immediate revolution in the field of genomics that has rippled into many branches of the life and physical sciences. The remarka...

High-throughput proteomic profiling of the fish liver following bacterial infection.

High-throughput proteomics was used to determine the role of the fish liver in defense responses to bacterial infection. This was done using a rainbow trout (Oncorhynchus mykiss) model following infec...

Clinical Trials [3008 Associated Clinical Trials listed on BioPortfolio]

High Throughput Drug Sensitivity and Genomics Data in Developing Individualized Treatment in Patients With Relapsed or Refractory Multiple Myeloma or Plasma Cell Leukemia

This pilot clinical trial studies whether using high throughput drug sensitivity and genomics data is feasible in developing individualized treatment in patients with multiple myeloma or p...

High Throughput Drug Sensitivity Assay and Genomics- Guided Treatment of Patients With Relapsed or Refractory Acute Leukemia

This clinical trial studies the feasibility of choosing treatment based on a high throughput ex vivo drug sensitivity assay in combination with mutation analysis for patients with acute le...

Evaluation of the Diagnostic Contribution of High-throughput Exome Sequencing for Patients With Convulsive Encephalopathy of Unknown Etiology: Pilot Study to Improve Genetic Counselling

Congenital epileptic encephalopathies (EE) are predominantly genetic in origin. Their diagnosis is hampered by the large number of genes involved and their low recurrence. Genetic study in...

Optimization of HIV-1 DNA Genotyping by High Throughput Sequencing to Document Antiretroviral Resistant Mutations

The analysis of HIV resistance to antiretrovirals (Sanger sequencing on RNA) is difficult when the viral load is undetectable or during therapeutic breaks. In these situations, the high th...

Screening for Genes in Patients With Congenital Neutropenia

Syndromic congenital neutropenia (SCN) includes a heterogeneous group of diseases characterized by congenital neutropenia associated with the involvement of other organs. Most patients hav...

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Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...

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