High Throughput Genomics, Inc Company Profile

14:13 EDT 19th June 2018 | BioPortfolio

High Throughput Genomics (HTG) was founded to: Develop and market ArrayPlate measurement of gene expression, DNA and proteins.
Develop and market gene expression quantitative Nuclease Protection Assays (qNPA™).
Satisfy unmet needs encountered at all levels of drug discovery, clinical development, and clinical practice.
Other commercialized methods for drug discovery lack sensitivity and have poor reproducibility. As a result low and moderately expressed genes that change slightly but significantly in disease states cannot be identified accurately against background assay noise.
HTG introduced the ArrayPlate, its first qNPA product, to measure multiple gene expression targets simultaneously. The ArrayPlate combines the high sample throughput of traditional microplates with HTG's novel Universal Array™ technology, permitting investigators to customize the genes measured in each well using a simple bench-top[ reagent addition procedure, producing self-customized arrays. With the combination of these two technologies, researchers now have access to the excellent sensitivity required to detect small changes and weak activity and the reproducibility of conventional biochemical assays in a multiplexed format permitting the measurement of sets of from 2 to 128 or more genes for high volume profiling of gene expression. In practical terms, this combination provides sensitivity down to 1,000 cells on 0.01 micrograms of total RNA and exceptional reproducibility of 3% to 13% coefficient of variation (C.V.) across the entire assay for cellular in vitro and in vivo tissue assays. The ability to easily measure gene expression from fixed tissue with the same high quality as from cells or frozen tissue is unique to qNPA


6296 E. Grant Road
United States of America


Phone: (520) 547-2827
Fax: (520) 547-2837

News Articles [894 Associated News Articles listed on BioPortfolio]

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PubMed Articles [1803 Associated PubMed Articles listed on BioPortfolio]

Chemical Genomics Translatability from Unicellular to Multicellular Models.

Chemical genomics has proven to be a useful and successful approach to study complex systems where conventional genetics fails to render feasible results. High-throughput phenotype screenings in model...

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Droplet-based microfluidic analysis and screening of single plant cells.

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Change of Title: Microarrays Becomes High-Throughput.

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Clinical Trials [2757 Associated Clinical Trials listed on BioPortfolio]

High Throughput Drug Sensitivity and Genomics Data in Developing Individualized Treatment in Patients With Relapsed or Refractory Multiple Myeloma or Plasma Cell Leukemia

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High Throughput Drug Sensitivity Assay and Genomics- Guided Treatment of Patients With Relapsed or Refractory Acute Leukemia

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Optimization of HIV-1 DNA Genotyping by High Throughput Sequencing to Document Antiretroviral Resistant Mutations

The analysis of HIV resistance to antiretrovirals (Sanger sequencing on RNA) is difficult when the viral load is undetectable or during therapeutic breaks. In these situations, the high th...

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Syndromic congenital neutropenia (SCN) includes a heterogeneous group of diseases characterized by congenital neutropenia associated with the involvement of other organs. Most patients hav...

Contribution of High-throughput Exome Sequencing in the Diagnosis of the Cause Fetal Polymalformation Syndromes

This research concerns the contribution of a new examination, high-throughput exome sequencing, in the diagnosis of the cause of polymalformative fetal syndromes. With currently available ...

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