International Society for the Study of Xenobiotics Company Profile

00:11 EDT 24th March 2018 | BioPortfolio

Man's use of xenobiotics dates from antiquity but interest in foreign compound metabolism dates from only the mid-19th century when the knowledge and techniques of organic chemistry were first applied to its study. For nearly a century thereafter biotransformation was generally equated with "detoxication" or the elimination of a compound's biological activity.This view changed in the late 1930s with the discovery that the synthetic azo-dye Prontosil owed its life-saving antibacterial activity to its metabolite, sulfanilamide. Since the 1950s the biological effects of numerous xenobiotic substances have been shown to be due to biotransformation products rather than the parent compound. The importance of biotransformation and other aspects of the interaction of xenobiotics with living systems has not escaped the notice of regulatory agencies worldwide. Their need for scientific knowledge on which to base regulations and safety evaluations for chemicals and drugs provides one important motivation for the study of xenobiotics. Of necessity, scientists working in such diverse fields as clinical and basic pharmacology, biochemistry, toxicology and oncology became drawn into metabolism studies, both in universities and research institutes and in the pharmaceutical, chemical, agro-chemical, food processing, tobacco and cosmetic industries. In 1981, a small group of scientists, brought together during the1970s under the aegis of the Gordon Research Conferences on Drug Metabolism, took the bold step of suggesting the organization of an international society to promote the interaction of scientists dedicated broadly to the study of xenobiotics in living systems. Thus the International Society for the Study of Xenobiotics was formed.


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Prognostic significance of the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification of stage I lung adenocarcinoma: A retrospective study based on analysis of 110 Chinese patients.

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Noninvasive quantitative analysis of ceramide in skin of healthy Chinese population.

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Comparison of two kinds of skin imaging analysis software: VISIA® from Canfield and IPP® from Media Cybernetics.

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Characterization of sweat induced with pilocarpine, physical exercise, and collected passively by metabolomic analysis.

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Concentration-controlled Therapy of Mycophenolate Mofetil (MMF) in Proliferative Lupus Nephritis

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Human Study of Hydroxytyrosol on Phase II Enzymes in Healthy Subjects

Explore the detoxifying potential of hydroxytyrosol and its effects on Phase II enzyme expression (leading to xenobiotics detoxification in the liver).

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International Society for the Study of Xenobiotics

Man's use of xenobiotics dates from antiquity but interest in foreign compound metabolism dates from only the mid-19th century when the knowledge and techniques of organic chemistry were first applied...

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The Gerontological Society of America

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