Circadian Technologies Limited Company Profile

14:46 EDT 21st March 2018 | BioPortfolio

Circadian Technologies Limited is an emerging leader in the field of angiogenesis-based treatments for cancer. Focusing on a class of drug targets called Vascular Endothelial Growth Factors (VEGFs), we seek to develop truly novel therapies to extend and improve the lives of cancer sufferers. Circadians strengths are the following:

Intellectual Property Circadian owns the worlds largest and most comprehensive intellectual property estate covering the key angiogenesis targets VEGF-C, VEGF-D and VEGFR-3. These IP rights include over 50 patent families, 200 granted patents and 500 patents pending worldwide.

Pipeline Circadian has an internal product pipeline comprising biologics-based drugs to three angiogenesis targets. Circadians most advanced program, VGX-100, an antibody-drug targeting VEGF-C, is expected to enter clinical trials in 2011.

Partners Circadian has commercial partnerships with other leading biotechnology companies for the development of products based on the companys technology. Ark Therapeutics is evaluating Trinam in Phase 3 clinical trials. ImClone Systems, a subsidiary of Eli Lilly and Company, is conducting preclinical studies of an anti-VEGFR-3 antibody for cancer treatment.

Management Circadian is run by some of the most experienced and successful people in the Australian biotechnology industry, with an extensive track record of success in product and business development. Members of Circadians leadership team have held past roles with Amgen, Genentech, GlaxoWellcome, Schering and Sanofi-Aventis, among other leading companies.

Financial strength Circadian has a strong financial position and substantial cash reserves.


Circadian Technologies was one of Australias earliest biotechnology companies and was listed on the Australian Stock Exchange in 1985. Originally functioning as a commercial vehicle for outstanding, diverse biomedical research, the company successfully launched and spun out many of Australias most well-known biotechnology companies including Axon Instruments, Optiscan Imaging and Antisense Therapeutics. In 2008 Circadian modified its strategy to focus on the development of biologics-based therapies for cancer, in particular leveraging the product pipeline and broad intellectual property assets of its 100 percent-owned subsidiary, Vegenics Pty Ltd. Vegenics Pty Ltd formally holds the intellectual property rights to develop Vascular Endothelial Growth Factor (VEGF)-based therapies.

Source: Circadian Technologies


Level 1
10 Wallace Avenue


Phone: 61 3 9826 0399
Fax: 61 3 9824 0083

News Articles [308 Associated News Articles listed on BioPortfolio]

Our circadian clock sets the rhythm for our cells’ powerhouses

Cellular energy metabolism also follows the rhythm of the circadian clock. A new study has now shown exactly how this works by revealing the relationship between the circadian rhythm and the mitochond...

Circadian clock, sleep and the regulation of the human body

Night shifts: Circadian biology for public health

The award of the 2017 Nobel Prize in Physiology or Medicine has piqued public and scientific interest in circadian research (see Nature550, 18;10.1038/nature.2017.227362017). The time has come to tran...

Cancer Overrides the Circadian Clock to Survive

Misfolded proteins cause disruptions in circadian rhythm that contribute to tumor growth

Our circadian clock sets the rhythm for our cells' powerhouses

(University of Basel) Cellular energy metabolism also follows the rhythm of the circadian clock. A University of Basel study has now shown exactly how this works by revealing the relationship between ...

New pathway may provide clues to ‘jet-lag effect,’ regulating circadian rhythms

Russell G. FosterCHICAGO — A recently discovered pathway responsible for suppressing the effect of light on the body’s internal “clock” may also provide a potential target for the regulation o...

What makes circadian clocks tick?

(Biophysical Society) Circadian clocks arose as an adaptation to dramatic swings in daylight hours and temperature caused by the Earth's rotation, but we still don't fully understand how they work. Du...

Environmental toxin exposure may disrupt function of circadian clock, research shows

Can environmental toxins disrupt circadian rhythms - the biological "clock" whose disturbance is linked to chronic inflammation and a host of human disorders? Research showing a link between circadian...

PubMed Articles [600 Associated PubMed Articles listed on BioPortfolio]

Just-So Stories and Origin Myths: Phosphorylation and Structural Disorder in Circadian Clock Proteins.

Some longstanding dogmas in the circadian field warrant reexamination in light of recent studies focused on the role of post-translational modifications and intrinsic disorder in core circadian clock ...

Circadian Rhythms Disturbances in Alzheimer Disease: Current Concepts, Diagnosis, and Management.

The purpose of this review is to provide an overview of the research regarding circadian rhythms in Alzheimer disease (AD). Furthermore, this paper explores the role of melatonin in the pathogenesis o...

The Circadian expression of Piezo1, TRPV4, Connexin26, and VNUT, associated with the expression levels of the clock genes in mouse primary cultured urothelial cells.

To investigate circadian gene expressions in the mouse bladder urothelium to establish an experimental model and study the functions of the circadian rhythm.

Bioinformatic Analysis of Circadian Expression of Oncogenes and Tumor Suppressor Genes.

Circadian rhythms are physiological and behavioral cycles with a period of approximately 24 hours that control various functions including gene expression. Circadian disruption is associated with a va...

Circadian Rhythm Sleep-Wake Disorders.

The endogenous circadian rhythms are one of the cardinal processes that control sleep. They are self-sustaining biological rhythms with a periodicity of approximately 24 hours that may be entrained by...

Clinical Trials [517 Associated Clinical Trials listed on BioPortfolio]

Pilot Study of the Effects of Circadian Rhythms on the Treatment of Bipolar I Depression.

The objective of this pilot study is to test the feasibility of a larger planned trial. The objective of this larger trial will be to determine the extent to which aspects of circadian rhy...

Safety and Efficacy of VEC-162 on Circadian Rhythm in Healthy Adult Volunteers

The purpose of this study is to assess the safety and efficacy of VEC-162 compared to matching placebo on circadian phase shift and sleep parameters.

Obesity and Heart Health

A multidisciplinary investigation examining the circadian mechanisms regulating cardiovascular risk in obesity. Specifically, in a valid circadian protocol, the investigators aim to study ...

Circadian Adjusted LED Light's Effect in People Living in Elderly Housing

Europe is undergoing a demographic change with a rapidly growing population of 65 years+. This challenges municipalities and hospitals as the ageing citizens need care and treatment due to...

The Circadian Rhythm of Copeptin

The circadian rhythm of copeptin will be examined in healthy subjects.

Companies [1336 Associated Companies listed on BioPortfolio]

Circadian Technologies Limited

Circadian Technologies Limited is an emerging leader in the field of angiogenesis-based treatments for cancer. Focusing on a class of drug targets called Vascular Endothelial Growth Factors (VEGFs),...

Reset Therapeutics, Inc.

Reset, a discovery-stage biopharma company co-founded by leaders in the field of circadian biology and Bay City Capital, is developing first-in-class approaches to treating diseas...

First Warning Systems, Inc.

Temperature readings of breast tissue create Dynamic Thermal Finger Prints (DTFP) which are correlated to dysfunctional circadian genes. Multiple bioinformatics algorithms compare...

Microsulis Medical Limited

Founded in 1997, Microsulis Medical Limited is a UK-based medical device company that exploits specialist intellectual property in medical microwave design to create therapeutic d...

Immunocore Limited

Immunocore Limited is developing innovative biological therapeutics to treat a range of cancers, chronic viral infections and diabetes. Immunocore is a privately owned biotechnology company located ...

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