Circadian Technologies Limited Company Profile

22:29 EST 14th December 2018 | BioPortfolio

Circadian Technologies Limited is an emerging leader in the field of angiogenesis-based treatments for cancer. Focusing on a class of drug targets called Vascular Endothelial Growth Factors (VEGFs), we seek to develop truly novel therapies to extend and improve the lives of cancer sufferers. Circadians strengths are the following:

Intellectual Property Circadian owns the worlds largest and most comprehensive intellectual property estate covering the key angiogenesis targets VEGF-C, VEGF-D and VEGFR-3. These IP rights include over 50 patent families, 200 granted patents and 500 patents pending worldwide.

Pipeline Circadian has an internal product pipeline comprising biologics-based drugs to three angiogenesis targets. Circadians most advanced program, VGX-100, an antibody-drug targeting VEGF-C, is expected to enter clinical trials in 2011.

Partners Circadian has commercial partnerships with other leading biotechnology companies for the development of products based on the companys technology. Ark Therapeutics is evaluating Trinam in Phase 3 clinical trials. ImClone Systems, a subsidiary of Eli Lilly and Company, is conducting preclinical studies of an anti-VEGFR-3 antibody for cancer treatment.

Management Circadian is run by some of the most experienced and successful people in the Australian biotechnology industry, with an extensive track record of success in product and business development. Members of Circadians leadership team have held past roles with Amgen, Genentech, GlaxoWellcome, Schering and Sanofi-Aventis, among other leading companies.

Financial strength Circadian has a strong financial position and substantial cash reserves.


Circadian Technologies was one of Australias earliest biotechnology companies and was listed on the Australian Stock Exchange in 1985. Originally functioning as a commercial vehicle for outstanding, diverse biomedical research, the company successfully launched and spun out many of Australias most well-known biotechnology companies including Axon Instruments, Optiscan Imaging and Antisense Therapeutics. In 2008 Circadian modified its strategy to focus on the development of biologics-based therapies for cancer, in particular leveraging the product pipeline and broad intellectual property assets of its 100 percent-owned subsidiary, Vegenics Pty Ltd. Vegenics Pty Ltd formally holds the intellectual property rights to develop Vascular Endothelial Growth Factor (VEGF)-based therapies.

Source: Circadian Technologies


Level 1
10 Wallace Avenue


Phone: 61 3 9826 0399
Fax: 61 3 9824 0083

News Articles [340 Associated News Articles listed on BioPortfolio]

Disrupted circadian clocks and altered tissue mechanics in primary human breast tumours

Circadian rhythms maintain tissue homeostasis during the 24-h day-night cycle. Cell-autonomous circadian clocks play fundamental roles in cell division, DNA damage responses and metabolism. Circadian ...

Ghrelin is impacted by the endogenous circadian system and by circadian misalignment in humans

Circadian System, Misalignment Have Distinct Impact on Insulin

WEDNESDAY, July 11, 2018 -- The endogenous circadian system, behavioral cycle, and circadian misalignment have distinct effects on insulin sensitivity and β-cell function, according to a study publis...

Circadian Regulator Effective for Jet Lag

The circadian regulator tasimelteon improves nightly sleep time and next-day alertness in transatlantic travelers with jet lag disorder. Medscape Medical News

Seizure Cycles May Follow Circadian Rhythms

Epileptic seizures often follow a circadian rhythm, which may eventually help guide therapy, researchers say. Medscape Medical News

Genetic link discovered between circadian rhythms and mood disorders

In the largest ever genetic study of circadian rest-activity cycles in humans, scientists at the University of Glasgow, supported by data from the NIHR oxford Biomedical Research Centre (BRC), have id...

[Review] Circadian rhythm and epilepsy

Advances in diagnostic technology, including chronic intracranial EEG recordings, have confirmed the clinical observation of different temporal patterns of epileptic activity and seizure occurrence ov...

Research focuses on a new frontier in circadian rhythms

(Rensselaer Polytechnic Institute) A new frontier in the science of circadian rhythms -- whose disruption is linked to major diseases like cancer and diabetes -- suggests a previously unknown mechanis...

PubMed Articles [574 Associated PubMed Articles listed on BioPortfolio]

Ultraviolet b radiation modifies circadian time in epidermal skin and in subcutaneous adipose tissue.

Recent findings suggest that circadian time regulates cellular functions in the skin and may affect protection against ultraviolet radiation (UVR). It is not known, however, whether UVR through skin d...

Neurodegeneration-associated FUS is a novel regulator of circadian gene expression.

Circadian rhythms are oscillating physiological and behavioral changes governed by an internal molecular clock, and dysfunctions in circadian rhythms have been associated with ageing and various neuro...

Circadian and Sleep Circuits Ring Together.

Prolonged wakefulness stimulates the homeostatic need to sleep, but transition to sleep also depends on the circadian time of day. However, links between circadian and homeostatic influences are not w...

Hypothesis: ubiquitous circadian disruption can cause cancer.

Circadian disruption (CD) was implicated in chains of cancer causation when the International Agency for Research on Cancer classified shift-work involving circadian disruption as probably carcinogeni...

Modeling the crosstalk between the circadian clock and ROS in Neurospora crassa.

The circadian clock regulates the expression of clock-controlled genes and adapts to environmental changes. Reactive oxygen species (ROS) also undergo circadian rhythms and have a role in circadian ti...

Clinical Trials [651 Associated Clinical Trials listed on BioPortfolio]

Pilot Study of the Effects of Circadian Rhythms on the Treatment of Bipolar I Depression.

The objective of this pilot study is to test the feasibility of a larger planned trial. The objective of this larger trial will be to determine the extent to which aspects of circadian rhy...

Implementing and Sustaining a Transdiagnostic Sleep and Circadian Treatment

The goal is to collect pilot data on an adapted version of the Transdiagnostic Sleep and Circadian intervention (TranS-C), referred to as 'Fitted TranS-C'. We seek to determine if Fitted T...

Safety and Efficacy of VEC-162 on Circadian Rhythm in Healthy Adult Volunteers

The purpose of this study is to assess the safety and efficacy of VEC-162 compared to matching placebo on circadian phase shift and sleep parameters.

Obesity and Heart Health

A multidisciplinary investigation examining the circadian mechanisms regulating cardiovascular risk in obesity. Specifically, in a valid circadian protocol, the investigators aim to study ...

Circadian Adjusted LED Light's Effect in People Living in Elderly Housing

Europe is undergoing a demographic change with a rapidly growing population of 65 years+. This challenges municipalities and hospitals as the ageing citizens need care and treatment due to...

Companies [1379 Associated Companies listed on BioPortfolio]

Circadian Technologies Limited

Circadian Technologies Limited is an emerging leader in the field of angiogenesis-based treatments for cancer. Focusing on a class of drug targets called Vascular Endothelial Growth Factors (VEGFs),...

Reset Therapeutics, Inc.

Reset, a discovery-stage biopharma company co-founded by leaders in the field of circadian biology and Bay City Capital, is developing first-in-class approaches to treating diseas...

First Warning Systems, Inc.

Temperature readings of breast tissue create Dynamic Thermal Finger Prints (DTFP) which are correlated to dysfunctional circadian genes. Multiple bioinformatics algorithms compare...

Microsulis Medical Limited

Founded in 1997, Microsulis Medical Limited is a UK-based medical device company that exploits specialist intellectual property in medical microwave design to create therapeutic d...

Immunocore Limited

Immunocore Limited is developing innovative biological therapeutics to treat a range of cancers, chronic viral infections and diabetes. Immunocore is a privately owned biotechnology company located ...

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