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Medicago is a clinical-stage biopharmaceutical company developing novel vaccines and therapeutic proteins to address a broad range of infectious diseases worldwide. The Company is committed to providing highly effective and competitive vaccines and therapeutic proteins based on its proprietary Virus-Like Particles (VLPs) and manufacturing technologies. Medicago is a worldwide leader in the development of VLP vaccines using a transient expression system which produces recombinant vaccine antigens in plants. This technology has potential to offer more potent vaccines with speed and cost advantages over competitive technologies, enabling the development of a vaccine for testing in approximately one month after the identification and reception of genetic sequences from a pandemic strain. This production time frame has the potential to allow vaccination of the population before the first wave of a pandemic, and supply large volumes of vaccine antigens to the world market. Medicago also intends to expand development into other areas such as biosimilars and biodefense products where the benefits of our technologies can make a significant difference.
Medicago has reported positive results from its Phase II clinical trial with its avian flu H5 pandemic vaccine candidate. The vaccine was found to be safe, well tolerated and the results were among the most effective of the industry. Medicago also reported positive results from a U.S. Phase I human clinical trial with its seasonal influenza vaccine candidate. All vaccine doses were found to be safe, well tolerated and also induced a solid immune response that met the CHMP criteria, even with a single dose of 5 µg. Based on these results and subject to regulatory approval, Medicago intends to proceed with a U.S. Phase IIa trial for its seasonal quadrivalent vaccine with the recommended H1N1, H3N2 and two B influenza strains.
Medicago operates a 24,000-square-foot production facility located in the Technology Park in Quebec City, Canada. This facility includes a Biosafety level 2 greenhouse, an extraction and purification unit, and is cGMP compliant. Medicago is producing the preclinical and clinical lots required for the development of its influenza vaccines from its existing facility.
Medicago U.S.A., a wholly owned subsidiary of Medicago Inc., has completed the construction of its facility in Research Triangle Park (RTP), North Carolina. This Virus-Like-Particle plant-based vaccine facility includes a fully automated greenhouse and a state of the art extraction and purification unit. The 97,000-square-foot cGMP facility is targeted to produce 10 million doses of pandemic influenza vaccine per month. On an annual basis, the facility could have production capacity of 30 million doses of quadrivalent seasonal influenza vaccine or 120 million doses of pandemic influenza vaccine.
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Medicago truncatula is an established model for studying legume biology. More recently, it has also been exploited as a Molecular Farming platform for the production of recombinant proteins, with the ...
As the FDA meets to plan next year's flu vaccine, companies like Medicago are testing innovative technologies designed to minimize the risk of another devastating outbreak.
SummaryMedicago Inc Medicago, a subsidiary of Mitsubishi Tanabe Pharma Corp is a clinicalstage biotechnology company that develops and produces vaccines and antibodies. The company concentrates on the...
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Glutathione S-transferases are ubiquitous enzyme in plants, playing vital roles in several physiological and developmental processes. In this study we identified 73 GST genes from the genome of Medica...
Salt stress is one of the primary abiotic stresses responsible for decreasing crop yields worldwide. Germinating seeds can be greatly influenced by saline conditions. In this study, the physiological ...
Almost all legume plants have the capacity to form two types of root organs: lateral roots and nodules (that will host rhizobia that fix nitrogen). Transcriptomic analyses are useful to understand bot...
MtCLE12 and MtCLE13 encode CLAVATA3/EMBRYO-SURROUNDING REGION RELATED (CLE) peptides which regulate autoregulation of nodulation (AON) in Medicago through the shoot receptor, SUNN (SUPER NUMERIC NODUL...
Aluminum (Al) toxicity can induce oxidative and nitrosative stress, which limits growth and yield of crop plants. Nevertheless, plant tolerance to stress may be improved by symbiotic associations incl...
Medicago is a clinical-stage biopharmaceutical company developing novel vaccines and therapeutic proteins to address a broad range of infectious diseases worldwide. The Company is committed to provi...
We have published hundreds of Medicago news stories on BioPortfolio along with dozens of Medicago Clinical Trials and PubMed Articles about Medicago for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Medicago Companies in our database. You can also find out about relevant Medicago Drugs and Medications on this site too.
Biopharmaceuticals are medical drugs produced using biotechnology. They include proteins (including antibodies), nucleic acids (DNA, RNA or antisense oligonucleotides) and living microorganisms like virus and bacteria where the virulance of viruses and b...
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A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe, its toxins or one ...