Molecular Templates Inc. Company Profile

16:36 EDT 23rd March 2018 | BioPortfolio

Molecular Templates Inc. is creating an entirely new generation of potent anti-cancer agents based on proprietary applied proteomics technologies.The novel therapeutic agents in development by MTI are aimed particularly at melanoma, prostate and other metastatic cancers. Such agents are derived from the sophisticated mutation and selection of Shiga-like toxin (SLT) variants using recombinant DNA and proprietary ‘applied proteomics’ technologies.
New SLT therapeutic agents are created via a systematic approach involving the generation of a large number of mutant SLT genetic sequences that form a permanent combinatorial DNA library. From the library, SLT mutant genes are expressed and the corresponding protein toxins are screened for their ability to kill cancer cell-lines, whilst leaving normal human cell-lines unharmed.


MaRS Centre, 101 College Street, Suite 150
M5H 3W4


Phone: 416 946 2875
Fax: 416 946 6529

News Articles [482 Associated News Articles listed on BioPortfolio]

Molecular Templates reverse merges with Threshold Pharmaceuticals

Molecular Templates Inc. and Threshold Pharmaceuticals Inc. have reversed merged to form a new entity, which will take the Molecular Templates name and focus on continued development of two key cancer...

Molecular Templates closes $40mm PIPE following reverse merger

Oncology firm Molecular Templates Inc. grossed $40mm through a private placement of 5.8mm units priced at $6.90. Each unit was comprised of one common share and a warrant to purchase 0.50 shares of co...

Takeda, Molecular Templates collaborate in oncology drug discovery

Takeda Pharmaceutical Co. Ltd., through its Millennium Pharmaceuticals division (now known as Takeda Oncology), and Molecular Templates Inc. (MTI) have agreed to collaborate on multi-target drug disc...

Molecular Templates enters $10mm debt facility with Perceptive; draws down $5mm

Molecular Templates Inc. (developing engineered toxin bodies as cancer therapeutics) closed a $10mm debt facility with Perceptive Advisors. The company drew down a $5mm term loan immediately, and will...

AbCheck, Molecular Templates partner to identify oncology antibodies

Molecular Templates Provides Corporate Update and Outlines 2018 Milestones

Takeda Nominated Two Targets Under Research Collaboration in Dec. 2017 Updated MT-3724 Clinical Results Expected in 1H18 At Least Two New MTEM Products to Enter the Clinic in 2018 AUSTIN, Texas...

Molecular Templates, Inc. Reports Third Quarter 2017 Financial Results

Completed Merger with Threshold Pharmaceuticals in August  Recent Equity Financings of $60 Million Provide Cash Runway into late 2019 MT-3724 Advancing in Clinical Trials with New Data Expected...

Molecular Templates to Present at the Oppenheimer 28th Annual Healthcare Conference

AUSTIN, Texas, March 19, 2018 (GLOBE NEWSWIRE) -- Molecular Templates, Inc., (Nasdaq:MTEM) a clinical stage biopharmaceutical company focused on the discovery and development of Engineered Toxin ...

Drugs and Medications [2 Associated Drugs and Medications listed on BioPortfolio]

Nilandron [sanofi-aventis U.S. LLC]

NILANDRON (nilutamide)Tablets

Salsalate [Libertas Pharma, Inc.]

Salsalate Tablets, USP 500 and 750 mgRx Only

PubMed Articles [716 Associated PubMed Articles listed on BioPortfolio]

Combined Layer/Particle Approaches in Surface Molecular Imprinting of Proteins: Signal Enhancement and Competition.

Herein we report novel approaches to the molecular imprinting of proteins utilizing templates sizing around 10 nm and some 100 nm. The first step comprised synthesizing nanoparticles of molecularly im...

Evaluation of standardized and study-specific diffusion tensor imaging templates of the adult human brain: Template characteristics, spatial normalization accuracy, and detection of small inter-group FA differences.

Digital diffusion tensor imaging (DTI) templates of the adult human brain are commonly used in neuroimaging research, and their characteristics influence the accuracy of the application. However, a sy...

An Investigation into the Trueness and Precision of Copy Denture Templates Produced by Rapid Prototyping and Conventional Means.

To assess the trueness and precision of copy denture templates produced using traditional methods and 3D printing.

Automated reaction database and reaction network analysis: extraction of reaction templates using cheminformatics.

Both the automated generation of reaction networks and the automated prediction of synthetic trees require, in one way or another, the definition of possible transformations a molecule can undergo. On...

NGS-based analysis of base-substitution signatures created by yeast DNA polymerase eta and zeta on undamaged and abasic DNA templates in vitro.

Translesion synthesis (TLS) is the mechanism in which DNA polymerases (TLS polymerases) bypass unrepaired template damage with high error rates. DNA polymerase η and ζ (Polη and Polζ) are major TL...

Clinical Trials [1201 Associated Clinical Trials listed on BioPortfolio]

Study of Medical Student Use of Templates to Document Outpatient Asthma Care in Electronic Medical Record

The purpose of the study is to measure the effectiveness of a social marketing-based medical education intervention on student use of evidence-based templates for documenting outpatient as...

Accuracy of Dental Implant Placement Using Two Different CBCT-derived Templates

The main purpose of the present study is to evaluate the dental implant placement using two different CBCT-derived templates and to study the related factors that affect accuracy so as to ...

The Application of Ticagrelor Combined With Low Molecular Weight Heparin During PCI

The purpose of this study is to determine ticagrelor combining with low molecular weight heparin is effective and safe during PCI or not.

In Vivo EGFR Molecular Classification

The investigators developed 18F-MPG as a targeted molecular imaging agent for noninvasive and repeatable detecting EGFR-activating mutational status.

Clinical Value of Molecular Genetic Analyzes in Gynecological Malignomas

The aim of the planned research project is to find out the clinical significance of molecular genetic analyzes in gynecological malignomas. In particular, it will be investigated how the k...

Companies [855 Associated Companies listed on BioPortfolio]

Molecular Templates

Molecular Templates is a biopharmaceutical company focused on the discovery and development of targeted biologic therapeutics using its novel Engineered Toxin Bodies (ETB) platfor...

Molecular Templates, Inc.

Molecular Templates is a venture-backed biopharmaceutical company focused on the discovery and development of a new class of targeted biologic therapeutics called Engineered Toxin...

Molecular Templates Inc.

Molecular Templates Inc. is creating an entirely new generation of potent anti-cancer agents based on proprietary applied proteomics technologies.The novel therapeutic agents in development by MTI are...

Goldfarb Branham LLP

ABT Molecular Imaging

ABT Molecular Imaging is a medical imaging company marketing its Generator, a production platform which produces unit doses of molecular imaging drugs for positron emission tomogr...

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