Nabi Biopharmaceuticals Company Profile

07:03 EST 12th December 2018 | BioPortfolio

NABI Biopharmaceuticals are a biopharmaceutical company focused on the development of products that address unmet medical needs in the areas of nicotine addiction and infectious disease. We leverage our experience and knowledge in powering the human immune system to target serious medical conditions in these areas. Our lead products in development are NicVAX® [ Nicotine Conjugate Vaccine ], an innovative and proprietary investigational vaccine for treatment of nicotine addiction and prevention of smoking relapse, and StaphVAX® [ Staphylococcus aureus Vaccine ], a new pentavalent vaccine designed to prevent S.aureus infections including those infections caused by the most dangerous antibiotic-resistant strains of S.aureus .

NicVAX is an investigational vaccine based on patented technology. Nicotine, a small molecule, can cross the blood-brain barrier and reach specific receptors in the brain, thereby leading to the highly addictive pleasure sensation experienced by smokers and users of nicotine products. NicVAX is designed to stimulate the immune system to produce antibodies that bind to nicotine. A nicotine molecule attached to an antibody is too large to cross the blood-brain barrier, and thus is unable to reach the receptors in the brain and trigger pleasure sensations. In November 2007, we announced the successful completion of a Phase IIb “proof-of-concept” clinical trial for our NicVAX development program. The Phase IIb study showed statistically significant rates of smoking cessation and continuous long-term smoking abstinence at 6 and 12 months for subjects injected with NicVAX as compared with subjects injected with a placebo.

StaphVAX is an investigational vaccine based on patented technology, including technology that we have licensed on an exclusive basis from the National Institutes of Health, or NIH. We are developing StaphVAX for use in patients who are at high risk of S.aureus infection and who are able to respond to a vaccine by producing their own antibodies.

NicVAX and StaphVAX will require additional development, including preclinical testing and human studies for StaphVAX and additional human testing for NicVAX as well as regulatory approvals, before we can market them. We are continuing to develop NicVAX and StaphVAX while we search for partners who will assist in the further development and commercialization of these products.


12276 Wilkins Ave
United States of America


Phone: 301-255-6803
Fax: 301-770-3097

News Articles [174 Associated News Articles listed on BioPortfolio]

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Transgene and Tasly Biopharmaceuticals Conclude Strategic Agreements for the Rights of Transgene's Virus-Based Immunotherapies TG6002 and TG1050 in Greater China

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PubMed Articles [36 Associated PubMed Articles listed on BioPortfolio]

A unique benzimidazole-naphthalene hybrid molecule for independent detection of Zn and N ions: Experimental and theoretical investigations.

Single crystal X-ray structurally characterized benzimidazole-naphthalene hybrid (NABI) functions as a unique dual analyte sensor that can detect Zn cation and N anion independently. The NABI forms ch...

Acknowledgement to Referees.

Characterisation of protein aggregation with the Smoluchowski coagulation approach for use in biopharmaceuticals.

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Harnessing the power of an expanded genetic code toward next-generation biopharmaceuticals.

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Selective N-terminal acylation of peptides and proteins with a Gly-His tag sequence.

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Clinical Trials [3 Associated Clinical Trials listed on BioPortfolio]

Open Label Phase 3 Study of NABI-IGIV 10% [(HUMAN)] In Subjects With Primary Immune Deficiency Disorders (PIDD)

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Nicotine Vaccination and Nicotinic Receptor Occupancy

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A Phase III Clinical Trial of a Haemophilus Influenzae Type b (Hib) Conjugate Vaccine

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