Nanodisc, Inc. Company Profile

21:04 EST 10th December 2018 | BioPortfolio

Nanodisc, Inc. owns an exclusive, world-wide commercial license to all applications of Nanodiscs™ – nano scale, discoidal structures composed of specially engineered proteins and phospholipid bilayers. “Nanodiscs™ were discovered and developed by Dr. Sligar, Company Co-Founder, Professor at University of Illinois at Urbana Champaign and a principal investigator in the federally funded Nanotechnology Center (NSEC) at Northwestern University. Nanodiscs™ offer pharmaceutical researchers and developers a vastly superior way to work with “cell membrane-associated molecules” (such as receptors, ion channels and enzymes), generally amphipathic molecules which offer exciting potential as drugs and drug targets but which are difficult and expensive to study with traditional methods. Because Nanodiscs™ offer naturalistic presentation of target molecules in a soluble form, they allow scientists to study and use membrane proteins in whole new ways to discover drugs. Naturalistic presentation and solubility also support the creation of novel therapeutics utilizing or consisting partly of Nanodiscs. The Company’s current technology allows the manufacture of Nanodiscs™ achieving industrial scale at extremely low cost with excellent precision.



Drugs and Medications [0 Results]


PubMed Articles [9 Associated PubMed Articles listed on BioPortfolio]

Nanodisc-Forming Scaffold Protein Promoted Retardation of Amyloid-Beta Aggregation.

Peptidic-nanodiscs are useful membrane-mimetic tools for structural and functional studies of membrane proteins, and membrane interacting peptides including amyloids. Here, we demonstrate anti-amyloid...

Sphingomyelin Ability to Act as Chiral Selector using Nanodisc Electrokinetic Chromatography.

Understanding how stereochemistry affects interactions with cell membranes is important for effective drug development. Chirality has been shown to greatly effect pharmaceutical distribution and metab...

A Nanodisc-Cell Fusion Assay with Single-Pore Sensitivity and Sub-millisecond Time Resolution.

During exocytosis, vesicles fuse with the plasma membrane and release their contents. The fusion pore is the initial, nanometer-sized connection between the plasma membrane and the cargo-laden vesicle...

Using Nanodiscs to Probe Ca-Dependent Membrane Interaction of Synaptotagmin-1.

In this chapter, we introduce a nanodisc-based experimental platform to study Ca-triggered membrane interaction of synaptotagmin-1. We describe and discuss in detail how to assemble this soluble mimet...

The Peptidisc, a simple method for stabilizing membrane proteins in detergent-free solution.

Membrane proteins are difficult to work with due to their insolubility in aqueous solution and quite often their poor stability in detergent micelles. Here, we present the peptidisc for their facile c...

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Companies [1 Associated Companies listed on BioPortfolio]

Nanodisc, Inc.

Nanodisc, Inc. owns an exclusive, world-wide commercial license to all applications of Nanodiscs™ – nano scale, discoidal structures composed of specially engineered proteins and phosphol...

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Collaborations in biotechnology
Commercial and academic collaborations are used throughout the biotechnology and pharmaceutical sector to enhance research and product development. Collaborations can take the form of research and evaluation agreements, licensing, partnerships etc. ...

Nanotechnology is the engineering of functional systems at the molecular scale. This covers both current work and concepts that are more advanced.  In its original sense, 'nanotechnology' refers to the projected ability to construct items fr...

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