Nanodisc, Inc. Company Profile

08:48 EDT 22nd September 2018 | BioPortfolio

Nanodisc, Inc. owns an exclusive, world-wide commercial license to all applications of Nanodiscs™ – nano scale, discoidal structures composed of specially engineered proteins and phospholipid bilayers. “Nanodiscs™ were discovered and developed by Dr. Sligar, Company Co-Founder, Professor at University of Illinois at Urbana Champaign and a principal investigator in the federally funded Nanotechnology Center (NSEC) at Northwestern University. Nanodiscs™ offer pharmaceutical researchers and developers a vastly superior way to work with “cell membrane-associated molecules” (such as receptors, ion channels and enzymes), generally amphipathic molecules which offer exciting potential as drugs and drug targets but which are difficult and expensive to study with traditional methods. Because Nanodiscs™ offer naturalistic presentation of target molecules in a soluble form, they allow scientists to study and use membrane proteins in whole new ways to discover drugs. Naturalistic presentation and solubility also support the creation of novel therapeutics utilizing or consisting partly of Nanodiscs. The Company’s current technology allows the manufacture of Nanodiscs™ achieving industrial scale at extremely low cost with excellent precision.



News Articles [3 Associated News Articles listed on BioPortfolio]

Delivering cancer treatment on a nanodisc helps eliminate tumours

In the wrestling match with cancer, chemoimmunotherapy is the new strong arm, and it is building muscle with a nanodisc disguised as "good cholesterol." Researchers at the University of Michigan Roge...

Delivering cancer treatment on a nanodisc helps eliminate tumors

(Michigan Medicine - University of Michigan) Researchers at the University of Michigan Rogel Cancer Center designed this new delivery system -- a drug hidden in a nanodisc -- to increase the number of...

Highly Efficient Transfer of 7TM Membrane Protein from Native Membrane to Covalently Circularized Nanodisc

Drugs and Medications [0 Results]


PubMed Articles [10 Associated PubMed Articles listed on BioPortfolio]

Nanodisc-Forming Scaffold Protein Promoted Retardation of Amyloid-Beta Aggregation.

Peptidic-nanodiscs are useful membrane-mimetic tools for structural and functional studies of membrane proteins, and membrane interacting peptides including amyloids. Here, we demonstrate anti-amyloid...

Sphingomyelin Ability to Act as Chiral Selector using Nanodisc Electrokinetic Chromatography.

Understanding how stereochemistry affects interactions with cell membranes is important for effective drug development. Chirality has been shown to greatly effect pharmaceutical distribution and metab...

Subcutaneous Nanodisc Vaccination with Neoantigens for Combination Cancer Immunotherapy.

While cancer immunotherapy provides new exciting treatment options for patients, there is an urgent need for new strategies that can synergize with immune checkpoint blockers and boost the patient res...

Covalently circularized nanodiscs; challenges and applications.

Covalently circularized nanodiscs (cNDs) represent a significant advance in the durability and applicability of nanodisc technology. The new cNDs demonstrate higher size homogeneity and improved stabi...

No Longer Hidden Secrets of Proton Pumping: The Resolution Revolution Enlightens V-ATPases.

In this issue of Molecular Cell, Roh et al. (2018) present a high-resolution cryo-EM structure of the nanodisc-reconstituted yeast Vproton channel that provides important new insights into subunit ar...

Clinical Trials [0 Results]


Companies [1 Associated Companies listed on BioPortfolio]

Nanodisc, Inc.

Nanodisc, Inc. owns an exclusive, world-wide commercial license to all applications of Nanodiscs™ – nano scale, discoidal structures composed of specially engineered proteins and phosphol...

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