Paradigm Therapeutics Ltd Company Profile

03:13 EDT 23rd March 2018 | BioPortfolio

Paradigm Therapeutics was founded in 1999 and has established world class target identification and validation capabilities based on gene knock out technology and in vivo pharmacology. The acquisition of Amedis Pharmaceuticals in January 2005 added key medicinal chemistry skills. The combined company has focused on the identification of novel, small molecule tractable targets with defined therapeutic utility within key gene families such as G-protein coupled receptors (GPCRs), ion channels and proteases. The company has developed a drug discovery pipeline comprising targets and late stage pre-clinical projects in key areas of unmet medical need in pain, CNS disorders, hormone dependent diseases such as prostate and breast cancer and metabolic diseases such as diabetes, hyperlipidemias, obesity and osteoporosis. In June 2005 Paradigm Therapeutics announced two major collaborations with Ortho-McNeil Pharmaceuticals (J&J) in pain and urinary urge incontinence and with Takeda in CNS disorders. The company is based in Cambridge UK and Singapore.


418 Cambridge Science Park
United Kingdom


Phone: 44 (0)1223 477910
Fax: 44 (0)1223 477911

News Articles [811 Associated News Articles listed on BioPortfolio]

Paradigm provides positive Phase IIa data of pentosan polysulfate

Australia-based Paradigm Biopharmaceuticals has reported positive top-line results from a Phase IIa clinical trial of pentosan polysulfate (PPS) conducted in...Read More... The post Paradigm provides ...

Should we be using a treat-to-target paradigm in addressing skeletal fragility?

The prevailing paradigm for treating patients with osteoporosis is to begin with a generic oral bisphosphonate, such as alendronate, unless there is a contraindication for doing so. Patients are usual...

Global Veterinary Therapeutics Market to Mark CAGR of 6.0% Over Next 10 Years - announces publication of its recently generated research report titled, "GlobalVeterinary Therapeutics MarketBy Type (Therapeutics Drugs, Therapeutics Vaccines, Feed Additives The...

PE Biosystems, Paradigm Genetics to Develop Bioinformatics Software for Functional Genomics

PE Biosystems Group (Foster City, CA) and Paradigm Genetics Inc. (Research Triangle Park, NC) have signed a five-year collaborative research agreement to develop bioinformatics software for functional...

What You Need to Know About Indalo Therapeutics

Indalo Therapeutics is based in St. Louis and was formed in October 2016 from the merger of Antegrin Therapeutics and Cascadia Therapeutics.

Paracel Genomic Analysis System Installed at Paradigm Genetics

Paradigm Genetics Inc. (Research Triangle Park, NC) has installed Paracel Inc.'s (Pasadena, CA) latest generation genomic analysis system, GeneMatcher, at their Research Triangle Park, NC headquarters...

Technical Perspectives on Argos Therapeutics, Omeros, Regulus Therapeutics, and Rhythm Pharma

Argos Therapeutics Durham, North Carolinaheadquartered Argos Therapeutics Inc.'s stock finished last Friday's session 3.20% higher at $0.15. A total volume of 1.81 million Read more...

Capricor Therapeutics to Present at the Piper Jaffray Healthcare Conference

About Capricor Therapeutics Capricor Therapeutics, Inc. (NASDAQ: CAPR) is a clinical-stage biotechnology company focused on the discovery, development and commercialization of first-in-class biolog...

PubMed Articles [632 Associated PubMed Articles listed on BioPortfolio]

Yet Another Glucose Variability Index: Time for a Paradigm Change?

Recent developments in intracellular protein delivery.

Protein therapeutics based on transcription factors, gene editing enzymes, signaling proteins and protein antigens, have the potential to provide cures for a wide number of untreatable diseases, but c...

Alternative therapeutics for self-limiting infections-An indirect approach to the antibiotic resistance challenge.

Alternative therapeutics for infectious diseases is a top priority, but what infections should be the primary targets? At present there is a focus on therapies for severe infections, for which effecti...

Regenerative Rehabilitation: Applied Biophysics Meets Stem Cell Therapeutics.

The emerging field of regenerative rehabilitation integrates biological and bioengineering advances in regenerative medicine with rehabilitative sciences. Here we highlight recent stem cell-based exam...

Cue-induced craving among inhalant users: Development and preliminary validation of a visual cue paradigm.

Cue-induced craving is known to be associated with a higher risk of relapse, wherein drug-specific cues become conditioned stimuli, eliciting conditioned responses. Cue-reactivity paradigm are importa...

Clinical Trials [338 Associated Clinical Trials listed on BioPortfolio]

Feasibility Study of Effective Methods for Training Pump Naïve Subjects To Use The Paradigm® System And Evaluate Effectiveness

Feasibility study to compare the effectiveness of the Paradigm Sensor Augmented System versus subjects continuing to administer insulin in multiple dose injections. Evaluate the educationa...

Impact of Ibis on Patients With Advanced COPD

The purpose of this research is to determine if Ibis™, a digital therapeutics solution developed by Senscio Systems, reduces the emergency room visits and hospitalizations of patients wi...

Use of the Paradigm 722 System to Improve Glycemic Control in Adult and Adolescent Subjects With Type 1 Diabetes

The purpose of this study is to determine whether Type 1 Diabetic subjects using the Paradigm 722 System, which is a glucose sensor-augmented insulin pump, can improve glycemic control whe...

HDL Acute Lipid Optimization in Homozygous Familial Hypercholesterolemia

Assess the effect on coronary atheroma of serial infusions of autologous selectively delipidated HDL/preβ enriched plasma following use of HDL Therapeutics PDS-2™ System

Trial Comparing Different Stimulation Paradigms in Patients Treated With Vagus Nerve Stimulation for Refractory Epilepsy

Patients with refractory epilepsy who are candidates for a treatment with vagus nerve stimulation will be prospectively randomized into 3 arms with different vagus nerve stimulation paradi...

Companies [1264 Associated Companies listed on BioPortfolio]

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The Paradigm Award Committee

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Paradigm Medical Industries

Founded in 1996, Paradigm Medical Industries, Inc. develops, manufactures, and markets diagnostic and surgical equipment for the ophthalmic market. The company specialized in powerful, easy-to-use, v...

Nimbus Therapeutics, LLC

Nimbus Therapeutics is a biotechnology company headquartered in Cambridge, Mass., that is pioneering a new computational technology-driven paradigm to rapidly advance a diverse pi...

Advance Paradigm Incorporated

Advance Paradigm is a leading independent provider of health benefit management services, providing pharmacy benefit management, disease management and clinical research programs. Advance Paradigm's m...

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