Phage Biotech Ltd. Company Profile

18:45 EDT 22nd June 2018 | BioPortfolio

Phage-Biotech Ltd. was incorporated in March 2000, as a new player in the emerging field of Phage Therapy. The Company’s mission is to develop proprietary Phage-based anti-infective therapeutics to combat the increasing number of antibiotic-resistant infections worldwide. The Company has two short-term strategic objectives:To identify and formulate proprietary topical Phage preparations from discovery through pre-clinical trials, with an initial focus on anti-Pseudomonas therapeutics, andTo develop and out-license proprietary reagents and buffers to promote Phage stability, adsorption, and infectivity of phage-based therapeutics.The Opportunity. Antibiotic resistant infectious diseases impose a significant burden on society, and surpass $30 billion in annual direct treatment costs in the U.S. alone. The high cost stems from several key factors: (1) Individuals infected with drug resistant organisms usually have a poor prognosis and are more likely to require hospitalization and (2) drug-resistant infections acquired in hospitals nearly triple the cost of hospital stays. The cost of antibiotic resistance is expected to grow larger as medical experts anticipate record increases of antibacterial resistance in the next decade.
Two factors emphasize the urgent need to continue research and development into new and innovative drugs for infectious diseases:Today’s escalating antibiotic crisis is the direct result of large scale and indiscriminant over-use of anti-infective drugs. Both the FDA and the CDC recognize that even if all antibiotic use were indeed to become appropriate, a mission almost impossible to achieve, resistance would not disappear. Pharmaceutical companies have exhausted the arsenal of known antibiotic classes. Currently, the launch of new antibacterial products usually includes stronger dose formulations of old antibiotic classes. This results in the development of more antibiotic resistant strains and increased resistance of current strains. New classes of antibiotics are desperately needed.Phage Therapy. Phage Therapy offers a new effective weapon to combat infectious diseases, for both resistant and sensitive bacteria strains. In Eastern Europe, Phage Therapy has been routinely used to treat a wide range of bacterial infections for over 70 years, with high efficacy and minimal side effects. Studies have demonstrated that commercial phage mixtures can achieve bacterial elimination in up to 80% or higher of clinical strains, a very high success rate compared to currently used new generation antibiotics, which typically reach only 60% success.


4 Pekeris St. Rabin Science Park


Phone: 972-8-9471837
Fax: 972-8-9471845

News Articles [1743 Associated News Articles listed on BioPortfolio]

First phage therapy center in the U.S. signals growing acceptance

Phage therapy went out of fashion in the U.S. decades ago. Now a new center at the University of California, San Diego wants to revive it to combat antibiotic-resistant infections.

Antibiotic Development Question: Should A Phage Library Equal One Application?

FDA may have to take a personalized medicine approach when deciding how to classify a phage bank used to create...   

Biotech raises funds to help produce phage therapies for bacterial infections

Biotechnology company, Pherecydes Pharma, has raised €8.7 million in a Series B round of funding, which it plans to use to support the production of phages for compassionate use in accordance with g...

Turning a phage

(University of California - San Diego) With microbial resistance to antibiotics growing into a major global health crisis, researchers at University of California San Diego School of Medicine, in coll...

Bacteria-Killing Viruses Could Stop You From Getting Food Poisoning

A group of Finnish scientists has demonstrated that phage could be used to prevent food poisoning by killing dangerous foodborne pathogens like Yersinia enterocolitica. Researchers at the University o...

Lesaffre invests €15.5m in phage start-up

Engineered Bacteriophage with Dual Tail Fibers that Targets Non-Native Pathogenic Host

Bacteriophage (“Phage”) is a virus that can infect and kill bacteria. Because of this ability, phage is now being considered as an alternative to antibiotics that fail to treat infections caused b...

Antibody selection method improves on phage display

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Stelara [Janssen Biotech, Inc.]

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PubMed Articles [183 Associated PubMed Articles listed on BioPortfolio]

Contemporary Phage Biology: From Classic Models to New Insights.

Bacteriophages, discovered about a century ago, have been pivotal as models for understanding the fundamental principles of molecular biology. While interest in phage biology declined after the phage ...

Sequencing, genome analysis and host range of a novel Ralstonia phage, RsoP1EGY, isolated in Egypt.

A novel Ralstonia phage was isolated from soil in Egypt. It was designated Ralstonia phage RsoP1EGY using our phage identifier naming approach to reflect the phage's bacterial host species, characteri...

Expert Opinion on Three Phage Therapy Related Topics: Bacterial Phage Resistance, Phage Training and Prophages in Bacterial Production Strains.

Phage therapy is increasingly put forward as a "new" potential tool in the fight against antibiotic resistant infections. During the "Centennial Celebration of Bacteriophage Research" conference in Tb...

Bypassing bacterial infection in phage display by sequencing DNA released from phage particles.

Phage display relies on a bacterial infection step in which the phage particles are replicated to perform multiple affinity selection rounds and to enable the identification of isolated clones by DNA ...

In Vivo Studies on the Influence of Bacteriophage Preparations on the Autoimmune Inflammatory Process.

Phage preparations used for phage therapy may have not only direct antibacterial action but also immunomodulating effects mediated by phages themselves as well as by bacterial antigens. Therefore phag...

Clinical Trials [18 Associated Clinical Trials listed on BioPortfolio]

Evaluation and Detection of Facial Propionibacterium Acnes Bacteria and Phage

This multi-center, outpatient study will extract and evaluate the presence of facial P. acnes bacteria and phage strains using pore strips on up to 400 human subjects.

Ascending Dose Study of the Safety of AB-SA01 When Topically Applied to Intact Skin of Healthy Adults

This study will examine the safety of ascending doses of AB-SA01 when topically applied to intact skin of healthy adults.

A Phase 3 Clinical Trial for a Rabies Vaccine (Vero Cell) for Human Use in Healthy Chinese Subjects

The purpose of this single-centre, randomized, double-blind, parallel control, phase 3 study is to evaluate the safety and immunogenicity of a rabies vaccine (Vero Cell) for human use in h...

Phase I Hepatitis C Vaccine Trial of Virosome-formulated Peptides

Pevion Biotech has designed a therapeutic vaccine to treat patients who suffer from chronic hepatitis C virus infection. The vaccine is based on a combination of the PeviPRO and PeviTER pl...

Phage II Trial of Stathmin as Predictive Biomarker for TPF Induction Chemotherapy in OSCC

To investigate the predictive value of stathmin expression as a predictive biomarker in OSCC patients, who treated with TPF (docetaxel, cisplatin and 5-fluorouracil ) induction chemotherap...

Companies [929 Associated Companies listed on BioPortfolio]

Phage Biotech Ltd.

Phage-Biotech Ltd. was incorporated in March 2000, as a new player in the emerging field of Phage Therapy. The Company’s mission is to develop proprietary Phage-based anti-infective therapeutics to ...

Phage Biotechnology Corp

Phage Biotechnology Corporation (Phage) is a Delaware Corporation, incorporated in 1998 and headquartered in Las Vegas, Nevada. The company has a manufacturing plant in Irvine, California, with resear...

Vincogen Corporation

Vincogen Corporation is a RF ID Biochip company established in year 2000 and has developed a proprietary radio-frequency (RF) biochip platform and T4 Phage Display platforms for use in several applica...

Special Phage Services

Few inventions in science and medicine have had such a profound effect on human health as the discovery and subsequent development of antibiotics. Following their introduction during World War II ma...

Adaptive Phage Therapeutics, Inc.

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