Proteome Factory AG Company Profile

06:57 EST 19th December 2018 | BioPortfolio

The Proteome Factory AG is a modern biotech company specialized in proteomics, protein analysis, target validation and bioinformatics. The proteomic key technology platform significantly increases the chances to identify new drug targets in emerging disease and biomarkers of disease state. Additionally, the finding of biomarkers significantly enhances the opportunities for individual disease treatment. The Proteome Factory AG has developed an R&D key technology platform in life sciences and biotechnology. This technology platform is continuously optimized regarding efficiency, quality, and quantity. Combination of the core technologies proteomics, protein analysis, target validation and bioinformatics enables Proteome Factory AG to offer most rapid and reliable analyses of all kind of protein containing samples including body fluids, cells, tissues, and plants. The innovative proteomics platform ensures high sensitive and simultaneous analyses of a vast amount of proteins.Reverse-Proteomics (pharmaco proteomics) facilitates investigation of molecular mode of action and toxicology of drugs and other compounds. Utilization and development of modern bioinformatic technologies are most relevant to the Proteome Factory AG. Integrated data mining and processing enhance quality and speed of interpretation.
Beside high resolution 2D electrophoresis (up to 60x30 cm) latest gel-free LC-MS based techniques are applied to proteome analysis. In combination with new prefractionation techniques low abundant proteins can be analyzed allowing the identification of new high potential targets and biomarkers (e.g. by depletion of albumin from serum samples or analysis of albumin-bound proteins). Furthermore combination of de novo peptide sequencing by state-of-the-art mass spectrometry, HPLC, N-terminal protein and peptide sequencing allows Proteome Factory a reliable identification of post translational modifications (e.g. phosphorylation) and characterization of proteins’ primary structure.
The Proteome Factory AG has filed several patents for proteomic techniques. Selective Peptide Exclusion Chromatography (SPEC) allows a significant reduction of sample complexity while its content of information is not affected. Metal coded tagging (MeCAT) is a novel class of labeling reagents allowing quantitative multiplex analyses of several complex protein samples at the same time. First time MeCAT allows absolute quantification of proteins and biomolecules at a very sensitive level and a linear dynamic detection range of up to 9 orders of magnitude. Thus MeCAT is much more powerful than alternative techniques like stable isotope tagging.




Phone: 49 (0)30 20616265
Fax: 49 (0)30 20616267

News Articles [122 Associated News Articles listed on BioPortfolio]

Alzheimer disease pathology and the cerebrospinal fluid proteome

Altered proteome profiles have been reported in both postmortem brain tissues and body fluids of subjects with Alzheimer disease (AD), but their broad relationships with AD pathology, amyloid patholog...

Advanced Proteome Expands Partnership with Heidelberg

Advancing this partnership is based off of the companies also announcing positive results from an animal study. The post Advanced Proteome Expands Partnership with Heidelberg appeared first on Investi...

Proteogenomic workflow using canonical cancer proteome and cancer-specific proteome shows that many tumor-specific antigens derive from non-coding regions  #NBTHighlight

Proteogenomic workflow using canonical cancer proteome and cancer-specific proteome shows that many tumor-specific antigens derive from non-coding regions  #NBTHighlight

BeiGene adopts GE ‘turnkey’ factory for anti-PD-1 mAb production

BeiGene will use GE Healthcare Life Sciencesâ âoff-the-shelfâ factory to manufacture monoclonal antibodies in Guangdong Province, China.

Thermal Protein Profiling May Offer New Insights on Antibiotic Resistance

Scientists from the European Molecular Biology Laboratory (EMBL) say they have adapted an existing technique to study the melting behavior of proteins so that it can be used for the study of bact...

Global Smart Factory Industry

NEW YORK, Oct. 16, 2018 /PRNewswire/ -- This report analyzes the worldwide markets for Smart Factory in US$. The Global market is further analyzed by Read more...

Blockchain App Factory Defines 3 Important Considerations for Launching Your Own STO

SINGAPORE, Dec. 8, 2018 /PRNewswire/ -- Blockchain App Factory, a pioneer in providing end-to-end solutions for tokenized securities lists down three important factors for Security Read more...

H D erhält Auftrag für Modernisierung des Scania Smart Factory Lab

STOCKHOLM, October 3, 2018 /PRNewswire/ -- H&D Wireless hat seine Partnerschaft mit Scania ausgebaut und wird ein weiteres GEPS-Innenortungssystem in Scanias Smart Factory Lab-Konzept in Read mor...

PubMed Articles [249 Associated PubMed Articles listed on BioPortfolio]

Monitoring Proteome Stress in Live Cells Using HaloTag-Based Fluorogenic Sensor.

Fluorescent folding sensor is a powerful tool to detect proteome stresses, including heat, osmotic, oxidative, and drug induced stresses. Monitoring proteome stress using these sensors allows us to di...

Comparison of the Rat and Human Dorsal Root Ganglion Proteome.

Dorsal root ganglion (DRG) are a key tissue in the nervous system that have a role in neurological disease, particularly pain. Despite the importance of this tissue, the proteome of DRG is poorly unde...

An update of the functional mitochondrial human proteome network.

Due to the pivotal role of mitochondrial alterations in several diseases, the Human Proteome Organization (HUPO) has promoted in recent years an initiative to characterize the mitochondrial human prot...

Analysis of PNGase F-resistant N-glycopeptides using SugarQb for Proteome Discoverer 2.1 reveals cryptic substrate specificities.

SugarQb ( is a freely available collection of computational tools for the automated identification of intact glycopeptides from high-resolution HCD MS/MS data-sets in the P...

iTRAQ-based quantitative analysis of age-specific variations in salivary proteome of caries-susceptible individuals.

Human saliva is a protein-rich, easily accessible source of potential biomarkers for the diagnosis of oral and systemic diseases. However, little is known about the changes in salivary proteome associ...

Clinical Trials [44 Associated Clinical Trials listed on BioPortfolio]

Studying Exposure to Trichloroethylene in Factory Workers in Guangdong Province, China

RATIONALE: Exposure to trichloroethylene in the workplace may increase the risk of damaging white blood cells. Learning about the long-term effects of trichloroethylene exposure in factory...

Alterations in the Plasma Proteome of Early-Onset Severe Preeclampsia

The hypothesis of this study is that many plasma proteins are altered in concentration and structure in preeclampsia and the elucidation of these alterations will add to the poorly underst...

Effect of Exercise on Muscle Proteome Signature

The aim of the study is to investigate skeletal muscle proteome signature changes induced by exercise training in young men

Improving Anemia Status of Female Garment Workers in Bangladesh: An Evaluation of Pilot Intervention in Four Factories

The current study is aimed at evaluating nutrition interventions to be implemented for improving health and nutritional status of female garments workers in 4 selected garment factories in...

The Effects of Trout Fed With a Vegetable Based Feed on Cardiovascular Risk Markers and Plasma Proteome

Fish from the aquaculture sector constitutes an increasing part of the fish consumption in Denmark. The most important farmed fish in Denmark is the rainbow trout. Due to limited access of...

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Proteome Factory AG

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Proteome Consult offers specific expertise concerning the design and management of proteomics studies. Proteome Consult can draw on extensive expertise relating to the investigation of mammalian tiss...

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