Synapse BV Company Profile

16:59 EST 21st January 2019 | BioPortfolio

Synapse BV is a working group within the Cardiovascular Research Institute Maastricht (CARIM) as well as a company within the Maastricht University Holding. It carries out developmental research in the field of the (patho-)physiology of haemostasis and thrombosis, operating in the niche between biochemistry and molecular biology on the one side and pharmaceutical- and clinical sciences on the other. It more specifically explores the overall function of the thrombin generating system in platelet poor- and platelet rich plasma and blood as a diagnostic tool and a pharmaceutical target. It cooperates with major pharmaceutical and diagnostic companies on such subjects as the mechanism of action of antiplatelet drugs and clotting factor inhibitors, the measurement of their effects in vitro and in vivo in animals and humans, as well as the development of diagnostic procedures based on the assessment of the overall function of the coagulation mechanism.


University MaastrichtP.O. Box 616
6200 MD


Phone: 31-43 3881675
Fax: 31-43 3884159

News Articles [25 Associated News Articles listed on BioPortfolio]

Fujifilm Inks Deals For Four New Synapse Enterprise Imaging Solution Deployments

STAMFORD, Conn.—FUJIFILM Medical Systems U.S.A., Inc., a leading provider of Enterprise Imaging and Medical Informatics solutions, continues to see growth as the Enterprise Imaging partner of choice...

Fujifilm Medical secures four new contracts for enterprise imaging solutions

Fujifilm Medical signed contracts with Lee Health, Nemours Children’s Health System, Hackensack Radiology Group, Anderson Health System. The contracts include Synapse 5 PACS, Synapse 3D, Synapse...

Engineers Model an Artificial Synapse After the Human Brain

NewsA team of researchers have developed an artificial synapse that does not process information like a digital computer, but rather mimics the analog way the human brain completes tasks.

Memristive device as an active synapse

(Lobachevsky University) Biological neurons are coupled unidirectionally through a special junction called a synapse. An electrical signal is transmitted along a neuron after some biochemical reaction...

If Only A.I. Had a Brain—Engineers Model an Artificial Synapse After the Human Brain

NewsResearchers have developed an "artificial synapse" that does not process information like a digital computer but mimics how the human brain completes tasks.

Neuregulin 3 promotes excitatory synapse formation on hippocampal interneurons

Hippocampal GABAergic interneurons are crucial for cortical network function and have been implicated in psychiatric disorders. We show here that Neuregulin 3 (Nrg3), a relatively little investigated ...

Early changes to synapse gene regulation may cause Alzheimer's disease

(Tokyo Medical and Dental University) TMDU-led Japanese research revealed a role for splicing proteins in the pathology of Alzheimer's disease. Increased phosphorylation of the SRRM2 protein, seen in ...

Synapse-specific plasticity governs the identity of overlapping memory traces

(Japan Science and Technology Agency) Each memory is stored in a specific population of neurons called engram cells. When a memory is linked with another to generate an associative memory, two memory ...

Drugs and Medications [0 Results]


PubMed Articles [92 Associated PubMed Articles listed on BioPortfolio]

Astrocytes "Chordinate" Synapse Maturation and Plasticity.

A key step in excitatory synapse maturation is the switch in AMPA receptor subunit composition to GluA2-containing calcium-impermeable receptors. Now, Blanco-Suarez et al. (2018) demonstrate that ast...

The Long and Short of It: A Dwarf Neurexin Suffices for Synapse Assembly.

Neurexins have been established as a major coordinator of synapse assembly, functioning through interactions with postsynaptic cell adhesion molecules. Kurshan et al. (2018) now show that a C. elega...

Class 4 Semaphorins and Plexin-B receptors regulate GABAergic and glutamatergic synapse development in the mammalian hippocampus.

To understand how proper circuit formation and function is established in the mammalian brain, it is necessary to define the genes and signaling pathways that instruct excitatory and inhibitory synaps...

A Protocol to Study T-Cell Signaling in an Immune Synapse by Microscopy.

The immune synapse is a complex cellular structure that enables cell-cell communications between immune cells, mainly at the interface of an effector T-cell and an antigen-presenting cell (APC) that e...

Rap2 and TNIK control Plexin-dependent tiled synaptic innervation in .

During development, neurons form synapses with their fate-determined targets. While we begin to elucidate the mechanisms by which extracellular ligand-receptor interactions enhance synapse specificity...

Clinical Trials [11 Associated Clinical Trials listed on BioPortfolio]

SYN120 a Dual 5-HT6/5-HT2A Antagonist Proof of Concept Study to Evaluate Its Safety, Tolerability and Efficacy in Parkinson's Disease Dementia (SYNAPSE)

The purpose of this study placebo-controlled, randomized, double-blind study is to assess the safety and efficacy of SYN120 in patients with Parkinson's disease dementia (PDD) already trea...

Efficacy and Safety Study of Intravenous Progesterone in Patients With Severe Traumatic Brain Injury

The SyNAPSe trial will study if giving intravenous (i.v.) progesterone within 8 hours of the injury for a total of 120 hours to severe traumatic brain injury patients improves their recove...

Altered Connections in the Spinal Cord to Reduce Hand Impairment After Stroke

The goals of this study are to leverage principles of spike timing-dependent plasticity (STDP) via non-invasive stimulation techniques to strengthen corticospinal transmission. Few studies...

The Role of the Coagulation Pathway at the Synapse in Prion Diseases

The study hypothesis is that that the deleterious effect of prions on the brain may be mediated (at least partially) by activation of serine proteases involved in the coagulation system. I...

the Efficacy and Safety of Sugammadex in Children 0-2 Years Old

Sugammadex is a selective antidote to muscle relaxants rocuronium bromide and vecuronium bromide. Sugammadex is a modified gamma-cyclodextrin, a compound that selectively binds rocuronium ...

Companies [8 Associated Companies listed on BioPortfolio]

Synapse Wireless, Inc.

Synapse Wireless, Inc. ( delivers proven, scalable M2M connectivity solutions designed to revolutionize business. Built on its award-winning SNAP® wire...

Synapse Biomedical, Inc.

Founded in 2002, Synapse Biomedical's mission is to provide life transforming treatments through the commercialization of neurostimulation platforms and build a sustainable enterp...


Established in 1997 by Managing Director Adam Sherlock to provide technology services exclusively to clients in the pharmaceutical and healthcare industries, The Synapse Partnership Limited operates t...

Synapse Biomedical Inc.

Synapse Biomedical, headquartered in Oberlin, Ohio, 30 miles west of Cleveland, was founded in 2002 to commercialize the NeuRx(TM) platform for treating a number of respiratory insufficiency condition...

Synapse Biomedical Inc

Synapse Biomedical, in collaboration with University Hospitals of Cleveland and Case Western Reserve University, is currently investigating the applications of the DPS System to people with respirator...

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Cardiovascular disease (CVD)
Acute Coronary Syndromes (ACS) Blood Cardiovascular Dialysis Hypertension Stent Stroke Vascular Cardiovascular disease (CVD) includes all the diseases of the heart and circulation including coronary heart disease (angina...

Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells.  In vertebrates, it is composed of blo...

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