Synapse BV Company Profile

18:03 EDT 23rd June 2018 | BioPortfolio

Synapse BV is a working group within the Cardiovascular Research Institute Maastricht (CARIM) as well as a company within the Maastricht University Holding. It carries out developmental research in the field of the (patho-)physiology of haemostasis and thrombosis, operating in the niche between biochemistry and molecular biology on the one side and pharmaceutical- and clinical sciences on the other. It more specifically explores the overall function of the thrombin generating system in platelet poor- and platelet rich plasma and blood as a diagnostic tool and a pharmaceutical target. It cooperates with major pharmaceutical and diagnostic companies on such subjects as the mechanism of action of antiplatelet drugs and clotting factor inhibitors, the measurement of their effects in vitro and in vivo in animals and humans, as well as the development of diagnostic procedures based on the assessment of the overall function of the coagulation mechanism.


University MaastrichtP.O. Box 616
6200 MD


Phone: 31-43 3881675
Fax: 31-43 3884159

News Articles [16 Associated News Articles listed on BioPortfolio]

Remake, refill, reuse: Recycling at the synapse revealed

(Okinawa Institute of Science and Technology (OIST) Graduate University) OIST Researchers have shown that the speed of neurotransmitter recycling at the synapse is determined by the refilling speed of...

Superconducting synapse may be missing piece for 'artificial brains'

Researchers at the National Institute of Standards and Technology (NIST) have built a superconducting switch that "learns" like a biological system and could connect processors and store memories in ...

Engineers design artificial synapse for 'brain-on-a-chip' hardware

Engineers have designed an artificial synapse in such a way that they can precisely control the strength of an electric current flowing across it, similar to the way ions flow between neurons. The tea...

Spectrin is a mechanoresponsive protein shaping fusogenic synapse architecture during myoblast fusion

Synapse Biomedical Inc. Receives CE Approval for TransAeris, the First Medical Device Approved for the Treatment of Ventilator Induced Diaphragm Dysfunction (VIDD)

Synapse Biomedical (, an innovator in neurostimulation and manufacturer of the NeuRx Diaphragm Pacing System®, announced today, the CE Mark approval for...

Critical period inhibition of NKCC1 rectifies synapse plasticity in the somatosensory cortex and restores adult tactile response maps in fragile X mice

Engineers design artificial synapse for ‘brain-on-a-chip’ hardware

Researchers in the emerging field of neuromorphic computing have attempted to design computer chips that work like the human brain...

Fundamental rule of brain plasticity

A series of complex experiments in the visual cortex of mice has yielded a simple rule about plasticity: When a synapse strengthens, others immediately nearby weaken.

Drugs and Medications [3 Associated Drugs and Medications listed on BioPortfolio]

Desipramine hydrochloride [STAT RX USA LLC]

Desipramine Hydrochloride Tablets, USP

Desipramine hydrochloride [Sandoz Inc]

Desipramine Hydrochloride Tablets, USP

Desipramine hydrochloride [Rebel Distributors Corp]

Desipramine Hydrochloride Tablets, USP

PubMed Articles [97 Associated PubMed Articles listed on BioPortfolio]

Molecular diversity underlying cortical excitatory and inhibitory synapse development.

The complexity and precision of cortical circuitries is achieved during development due to the exquisite diversity of synapse types that is generated in a highly regulated manner. Here, we review the ...

Sestd1 Encodes a Developmentally Dynamic Synapse Protein That Complexes With BCR Rac1-GAP to Regulate Forebrain Dendrite, Spine and Synapse Formation.

Molecular Dissection of Neuroligin 2 and Slitrk3 Reveals an Essential Framework for GABAergic Synapse Development.

In the brain, many types of interneurons make functionally diverse inhibitory synapses onto principal neurons. Although numerous molecules have been identified to function in inhibitory synapse develo...

A MIG-15/JNK-1 MAP kinase cascade opposes RPM-1 signaling in synapse formation and learning.

The Pam/Highwire/RPM-1 (PHR) proteins are conserved intracellular signaling hubs that regulate synapse formation and axon termination. The C. elegans PHR protein, called RPM-1, acts as a ubiquitin lig...

TRPM7 Is Required for Normal Synapse Density, Learning, and Memory at Different Developmental Stages.

The TRPM7 chanzyme contributes to several biological and pathological processes in different tissues. However, its role in the CNS under physiological conditions remains unclear. Here, we show that TR...

Clinical Trials [6 Associated Clinical Trials listed on BioPortfolio]

SYN120 a Dual 5-HT6/5-HT2A Antagonist Proof of Concept Study to Evaluate Its Safety, Tolerability and Efficacy in Parkinson's Disease Dementia (SYNAPSE)

The purpose of this study placebo-controlled, randomized, double-blind study is to assess the safety and efficacy of SYN120 in patients with Parkinson's disease dementia (PDD) already trea...

Efficacy and Safety Study of Intravenous Progesterone in Patients With Severe Traumatic Brain Injury

The SyNAPSe trial will study if giving intravenous (i.v.) progesterone within 8 hours of the injury for a total of 120 hours to severe traumatic brain injury patients improves their recove...

The Role of the Coagulation Pathway at the Synapse in Prion Diseases

The study hypothesis is that that the deleterious effect of prions on the brain may be mediated (at least partially) by activation of serine proteases involved in the coagulation system. I...

Memantine and Changes of Biological Markers and Brain PET Imaging in Alzheimer's Disease

In AD, tau protein is abnormally hyperphosphorylated. Significant changes of hyperphosphorylated tau levels in CSF are found in AD patients. It has been shown in vitro that memantine can r...

Pembrolizumab and Gemcitabine Chemotherapy in Leiomyosarcoma and Undifferentiated Pleomorphic Sarcoma

Soft tissue sarcomas (STS) are a group of rare mesenchymal neoplasms affecting all ages. STS most commonly present as localised disease but despite surgery and adjuvant treatment more than...

Companies [8 Associated Companies listed on BioPortfolio]

Synapse Wireless, Inc.

Synapse Wireless, Inc. ( delivers proven, scalable M2M connectivity solutions designed to revolutionize business. Built on its award-winning SNAP® wire...

Synapse Biomedical, Inc.

Founded in 2002, Synapse Biomedical's mission is to provide life transforming treatments through the commercialization of neurostimulation platforms and build a sustainable enterp...


Established in 1997 by Managing Director Adam Sherlock to provide technology services exclusively to clients in the pharmaceutical and healthcare industries, The Synapse Partnership Limited operates t...

Synapse Biomedical Inc.

Synapse Biomedical, headquartered in Oberlin, Ohio, 30 miles west of Cleveland, was founded in 2002 to commercialize the NeuRx(TM) platform for treating a number of respiratory insufficiency condition...

Synapse Biomedical Inc

Synapse Biomedical, in collaboration with University Hospitals of Cleveland and Case Western Reserve University, is currently investigating the applications of the DPS System to people with respirator...

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Relevant Topics

Cardiovascular disease (CVD)
Acute Coronary Syndromes (ACS) Blood Cardiovascular Dialysis Hypertension Stent Stroke Vascular Cardiovascular disease (CVD) includes all the diseases of the heart and circulation including coronary heart disease (angina...

Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells.  In vertebrates, it is composed of blo...

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