Human Protein Atlas (HPA) Company Profile

19:00 EST 9th December 2018 | BioPortfolio

The protein atlas contains histological images from sections of human tissue. These images are equivalent to what is seen in a microscope when examining sections of tissue on glass slides. Each antibody in the database has been used for immunohistochemical staining of both normal and cancer tissue. The immunohistochemical protocols used result in a brown-black staining, localized where an antibody has bound to its corresponding antigen. The tissue section is furthermore histochemically stained with hematoxylin to enable visualization of microscopical features. Hematoxylin staining is unspecific and results in a blue coloring of both cells and extracellular material.Tissue microarrays have been used to enable immunohistochemical staining of a large number and variety of normal and cancerous tissues. The design of used tissue microarrays include samples of 48 different normal tissue types and 20 different types of cancer. For each antibody, protein expression patterns in normal tissue can be viewed as triplicates from 144 different individuals and in cancer tissue viewed as duplicates from 216 different patients. Normally, a fraction of the 576 images are missing for each antibody due to technical issues. Samples of normal and cancer tissue have been collected from anonymized paraffin embedded material of surgical specimens, in accordance with approval from the local ethics committee





News Articles [1530 Associated News Articles listed on BioPortfolio]

Sixty seconds on . . . the Human Cell Atlas

Ah, an atlas where are we going?On a journey into the human body. This is a reference atlas of all human cells ( that has the potential to “impactalmost every aspect of biolog...

Experimental and computational framework for a dynamic protein atlas of human cell division

Chan Zuckerberg Initiative and Helmsley Charitable Trust team up on Human Cell Atlas

The Human Cell Atlas is a global scientist-led research

Ambitious ‘Human Cell Atlas’ Aims to Catalog Every Type of Cell in the Body

(NPR) – For the last two years Regev, a professor of biology at MIT, has been co-leading a massive international effort to get that answer. Called the Human Cell Atlas Consortium, the effort aim...

Human Cell Atlas study of early pregnancy shows how mother's immune system is modified

The first Human Cell Atlas study of early pregnancy in humans has shown how the function of the maternal immune system is affected by cells from the developing placenta.

From the Human Cell Atlas to dynamic immune maps in human disease

Brain cancer atlas debuted

A team of internationally renowned neurologists, bioinformaticians, and pathologists from the United States and India recently published details of the Ivy Glioblastoma Atlas in Science. The atlas m...

#jobs #lifescience Wellcome Sanger Institute: Senior Software Developer – Human Cell Atlas & Teichmann Lab

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Wellcome Sanger Institute: Senior Software Developer – Human Cell Atlas...

PubMed Articles [5064 Associated PubMed Articles listed on BioPortfolio]

HAVCR1 expression might be a novel prognostic factor for gastric cancer.

Hepatitis A virus cellular receptor 1 (HAVCR1), which is also known as T-cell immunoglobulin and mucin domain 1 (TIM-1) is a TIM gene family member. In this study, we aimed to characterize the express...

Book Review: The Breastfeeding Atlas Wilson-Clay B. Hoover K. ( 2017 ). The Breastfeeding Atlas ( 6th ed.) . Manchaca, TX : LactNews Press . 206 pp. $80.00 (spiral bound paperback), ISBN-13: 978-0-9672758-4-0 .

From the Human Cell Atlas to dynamic immune maps in human disease.

A probabilistic atlas of the human thalamic nuclei combining ex vivo MRI and histology.

The human thalamus is a brain structure that comprises numerous, highly specific nuclei. Since these nuclei are known to have different functions and to be connected to different areas of the cerebral...

Can atlas-based auto-segmentation ever be perfect? Insights from Extreme Value Theory.

Atlas-based segmentation is used in radiotherapy planning to accelerate the delineation of organs at risk (OARs). Atlas selection has been proposed to improve the performance of segmentation, assuming...

Clinical Trials [4879 Associated Clinical Trials listed on BioPortfolio]

Atlas of Human Cognition by SEEG (MAPCOG-SEEG)

The main objective of MAPCOG_SEEG is to create a database including brain recordings of cognition performed in clinical routine in patients during the pre-surgical SEEG assessment. This ai...

European Post-Market Study for Medial Knee Osteoarthritis Treated With the Atlas Knee System for Load Reduction

The objective of this study is to collect post market data on safety and performance of the Atlas Knee System in patients with osteoarthritis (OA) of the medial knee compartment through a ...

Developing an Atlas to Teach Nurses to Clean Micro-instruments Used in Cataract Surgery: Effect on Patient Safety

Aims and objectives The purpose of this study was to develop an atlas to explore the effect of micro-instrument cleaning on the safety of cataract surgery. Background Cataract surgery saf...

Noninferiority Trial of Liquid Human Milk Fortifier (HMF) Hydrolyzed Protein Versus Liquid HMF With Supplemental Liquid Protein

Breast milk is readily accepted as the ideal source of nutrition for almost all infants, including premature or very low birth weight infants. However, these high-risk infants require the ...

Atlas Predicted DBS Settings in Essential Tremor

Programming Deep Brain Stimulation for the treatment of Essential Tremor can be a time intensive process. Using an atlas created using functional tremor responses in the operating room to ...

Companies [1726 Associated Companies listed on BioPortfolio]

Confirmant Limited

Formed in June 2001, Confirmant is a joint venture between OGS and Marconi. It was conceived to develop, commercialise and market the output from OGS high throughput proteomics process.The first produ...

Human Protein Atlas (HPA)

The protein atlas contains histological images from sections of human tissue. These images are equivalent to what is seen in a microscope when examining sections of tissue on glass slides. Each antibo...

Atlas Medical Software

Atlas Medical delivers cost-effective outreach solutions for the healthcare enterprise that include integrated CPOE for Laboratory, Radiology, ePrescribing and other disciplines, ...

Atlas Development Corporation

ATLAS Medical delivers cost-effective outreach and clinical solutions for the healthcare enterprise that include integrated CPOE for Laboratory, Radiology, ePrescribing and ...

Padlock Therapeutics

Padlock Therapeutics is a private, Cambridge, Massachusetts-based biotechnology company dedicated to creating new medicines to treat destructive autoimmune diseases. The company l...

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Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...

Cancer Disease
Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for the organ or type of cell in which they start - for example, cancer that begins in the colon is called colon cancer; cancer th...

An antibody is a protein produced by the body's immune system when it detects harmful substances, called antigens. Examples of antigens include microorganisms (such as bacteria, fungi, parasites, and viruses) and chemicals. Antibodies may be produc...

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