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QTest Labs, Inc. Company Profile

17:13 EDT 22nd June 2018 | BioPortfolio

QTest Labs provides economical and rapid testing between drug discovery and preclinical trials . With a 2 week turn-around time and before conventional elaborate and expensive preclinical trials. QTest evaluates compounds for their effects on heart rate (RR interval), ventricular repolarization (QT and QTc), conductivity (P, PQ and QRS durations/intervals), inotropy (dP/dtmax), lusitropy (dP/dtmin) and coronary vascular resistance (dynes s cm-5). Studies are conducted on isolated perfused guinea pig hearts (Langendorff preparations) contracting isovolumetrically on a fluid-filled balloon. Recordings of high quality are of a bipolar cardiac electrogram, left ventricular pressure (LVP), and dLVP/dt. Coronary blood flow at a constant perfusion pressure is collected for 15 seconds. Most drug regulatory agencies accept studies conducted on isolated, perfused guinea pig hearts as a reasonable part of a comprehensive plan for drug safety evaluation. The value of using the Langendorff preparation is that it contains all tissues (e.g. Purkinje fibers, normal myocardium, “M” fibers) whose ionic channels may be affected by drugs. Therefore, although this preparation may be less sensitive than HERG channels or isolated superfused Purkinje fibers if a compound exerts toxicity on those structures, if the compound exerts potential toxicity by affecting some structures other than HERG channels or Purkinje fibers there is a possibility of identifying that potential toxicity in the Langendorff preparation possessing all cardiac tissues.

Location

6456 Fiesta Drive
Columbus
Ohio
43235
United States of America

Contact

Phone: 614-760-0800
Fax: 614-760-0900


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More Information about "QTest Labs, Inc." on BioPortfolio

We have published hundreds of QTest Labs, Inc. news stories on BioPortfolio along with dozens of QTest Labs, Inc. Clinical Trials and PubMed Articles about QTest Labs, Inc. for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of QTest Labs, Inc. Companies in our database. You can also find out about relevant QTest Labs, Inc. Drugs and Medications on this site too.

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Relevant Topics

Drug Discovery
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...

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