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Gene Signal Company Profile

13:05 EDT 22nd March 2019 | BioPortfolio

Gene Signal (www.genesignal.com) is developing a robust pipeline of novel antisense oligonucleotides, proteins and monoclonal antibodies to treat a range of conditions based on its innovative angiogenesis modulating technology. The company’s most advanced therapeutic product is aganirsen (GS-101), an antisense oligonucleotide that has nearly completed phase III for the prevention of corneal graft rejection. Aganirsen is also entering phase II clinical trials for additional angiogenesis based diseases, such as wet age-related macular degeneration (AMD), neovascular glaucoma, and dermal indications. Antisense oligonucleotides confer distinctive advantages versus other biologics: they can be readily transported across cell membranes, are associated with low immunogenicity, and can be produced by simple chemical synthesis, unlike larger proteins and monoclonal antibodies that require cell culture and complex purification steps.


News Articles [1684 Associated News Articles listed on BioPortfolio]

Gene Signal: Eric Viaud. Discovering genes involved in the regulation of angiogenesis

In this episode of PharmaTelevision News Review, filmed at BioEurope 2012 in Hamburg, Germany, Fintan Walton talks to Eric Viaud, CEO at Gene Signal

With $100M MeiraGTx Deal, J&J Signals Bigger Move Into Gene Therapy

Gene therapy has come of age over the past few years. And Johnson & Johnson this morning gave its biggest signal yet that it wants in on the emerging field. J&J (NYSE: JNJ) has inked a deal wi...

Roche Bets $4.8B on Spark Therapeutics and the Future of Gene Therapy

Roche has agreed to buy Spark Therapeutics for $4.8 billion, the latest strong signal that major pharmaceutical companies are ready to gamble on the promise of gene therapy despite its uncertain comme...

Sarepta Touts New Data And A “Signal” With Duchenne Gene Therapy

For the first time, a gene therapy—a one-time, long-lasting treatment—has shown it may improve the lives of kids with Duchenne muscular dystrophy, a deadly genetic disease with no cure. Pa...

Sarepta Touts New Data And Benefit “Signal” With Duchenne Gene Therapy

For the first time, a gene therapy—a one-time, long-lasting treatment—has shown it may improve the lives of kids with Duchenne muscular dystrophy, a deadly genetic disease with no cure. Pa...

Wirelessly Powered MRI Signal Amplification System and Method

The invention is in the field of MRI, and more specifically relates to device and method that may provide great improvements in the area of interventional MRI. The technology describes an MRI detectio...

Research Reveals Central Signal Sorting Hub in Plants

A research study has revealed the central signal sorting hub that plants use to coordinate biological processes. Dr. Vinod Kumar of the John Innes Centre (JIC) said that their research has revealed th...

Vaccinex completes enrollment for SIGNAL Huntington’s disease trial

In June 2015, Vaccinex, the Huntington Study Group (HSG), and the University of Rochester’s Clinical Trials Coordination Center (CTCC) launched SIGNAL, the first clinical trial to investigate a ...

Drugs and Medications [4 Associated Drugs and Medications listed on BioPortfolio]

Feridex i.v. (ferumoxides injectable solution) [bayer healthcare pharmaceuticals inc.]

Feridex I.V. (ferumoxides injectable solution)

Clindamycin phosphate [oceanside pharmaceuticals]

Clindamycin Phosphate Topical Gel (clindamycin phosphate gel) topical gel, 1%

Clindagel [onset dermatologics llc]

Clindagel (clindamycin phosphate gel) topical gel, 1%

R-gene [pharmacia and upjohn company llc]

R-Gene 10Arginine Hydrochloride Injection, USP

PubMed Articles [2572 Associated PubMed Articles listed on BioPortfolio]

A novel mathematical method for disclosing oscillations in gene transcription: A comparative study.

Circadian rhythmicity, the 24-hour cycle responsive to light and dark, is determined by periodic oscillations in gene transcription. This phenomenon has broad ramifications in physiologic function. Re...

Downregulated microRNA-340-5p promotes proliferation and inhibits apoptosis of chondrocytes in osteoarthritis mice through inhibiting the extracellular signal-regulated kinase signaling pathway by negatively targeting the FMOD gene.

Osteoarthritis (OA) is a degenerative joint disease that leads to the destruction of joint function. The aim of this study is to investigate the effects of microRNA-340-5p (miR-340-5p) and its target ...

Enhanced secretion of cyclodextrin glucanotransferase (CGTase) by Lactococcus lactis using heterologous signal peptides and optimization of cultivation conditions.

In previous studies of Lactococcus lactis, the levels of proteins secreted using heterologous signal peptides were observed to be lower than those obtained using the signal peptide from Usp45, the maj...

Self-sustaining Positive Feedback Loops in Discrete and Continuous Systems.

We consider a dynamic framework frequently used to model gene regulatory and signal transduction networks: monotonic ODEs that are composed of Hill functions. We derive conditions under which activity...

Discovering coherency of specific gene expression and optical reflectance properties of barley genotypes differing for resistance reactions against powdery mildew.

Hyperspectral imaging has proved its potential for evaluating complex plant-pathogen interactions. However, a closer link of the spectral signatures and genotypic characteristics remains elusive. Here...

Clinical Trials [2500 Associated Clinical Trials listed on BioPortfolio]

Investigation of Lithium on Signal Transduction, Gene Expression and Brain Myo-Inositol Levels in Manic Patients

This study investigates the effects of Lithium treatment on signal transduction pathways, gene expression and brain neurochemistry and structure in patients with Bipolar disorder. It is hy...

Noninvasively Predicting Gene Status of Glioma

Malignant gliomas are the most common and deadly primary brain tumors in adults. The clinical outcome of patients with glioblastoma depends on key molecular genetic alteration. Specificall...

Assessment of HyperQ Signal for Detecting Ischemia During Dobutamine Stress ECG

The purpose of the study is to verify the ability of the HyperQ signal to detect Dobutamine induced Ischemia. The gold standard for ischemia will be the results of Angiography if performed...

CLCF1 Gene Associated With Postmenopausal Osteoporosis of Kidney Yin Deficiency Syndrome

For nearly 112 million patients with osteoporosis in China, it is of great significance for preventing and treating by clearly understanding the molecular mechanism of kidney deficiency. T...

Effect of Pulsing Electrical Fields on Lower Extremity Diabetic Neuropathy: A Pilot, Open-Label Study

To determine if pulsed electric field therapy reduces lower leg and foot pain associated with diabetic neuropathy and lessens the need for medication. The MedRelief device sends a sub-thr...

Companies [683 Associated Companies listed on BioPortfolio]

Signal Bay Inc.

Signal Bay Inc., through its wholly owned subsidiaries Signal Bay Research, Inc. and Signal Bay Services, Inc. provides information, analysis, advisory services, and operating ser...

Gene Signal

Gene Signal (www.genesignal.com) is developing a robust pipeline of novel antisense oligonucleotides, proteins and monoclonal antibodies to treat a range of conditions based ...

Signal Bay, Inc.

Signal Bay Inc., home of the Cannabis Consultant Marketplace, provides research and expert consulting services to the legal cannabis industry. CANNAiQ, Signal Bay’s informati...

Signal Patterns

Signal Patterns develops social web applications that characterize and connect users to each other based on their interests, personality and preferences. With these scientific-based applications, ...

Signal Genetics

Signal Genetics is a privately held predictive genetic testing company focused on oncology. The goal of Signal Genetics is to provide cancer patients with their correlated predictive outcome of diseas...

More Information about "Gene Signal" on BioPortfolio

We have published hundreds of Gene Signal news stories on BioPortfolio along with dozens of Gene Signal Clinical Trials and PubMed Articles about Gene Signal for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Gene Signal Companies in our database. You can also find out about relevant Gene Signal Drugs and Medications on this site too.

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Relevant Topics

Bioinformatics
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...

Antisense therapy
Most human diseases are caused by production of abnormal proteins or malfunctioning proteins.   Antisense therapy involves inhibiting production of these proteins.  When a gene is known to cause a specific disease and the genetic sequence ...

Clincial Trials
In a clinical trial or interventional study, participants receive specific interventions according to the research plan or protocol created by the investigators. These interventions may be medical products, such as drugs or devices; procedures; or change...


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