Domain Therapeutics Company Profile

10:37 EDT 21st June 2018 | BioPortfolio

Domain Therapeutics is a biopharmaceutical company located in Strasbourg, France, dedicated to the discovery and early development of small molecules targeting G-coupled Protein Receptors (GPCRs), one of the best classes of drug targets.

Domain Therapeutics is using its innovative and proprietary technology platform DTect-All™ to identify orthosteric and allosteric ligands of GPCRs, including the so called Silent Allosteric Modulators (SAMs) that represent a unique source of compounds that cannot be discovered by standard technologies. DTect-All™ is able to address difficult GPCRs such as orphan and peptidic GPCRs.

The company’s pipeline is composed of new chemical entities ranging from hits to optimized leads targeting hot GPCRs for leading indications such as Parkinson’s disease, schizophrenia, Alzheimer’s disease and diabetes.


Boulevard Sébastien Brant


Phone: +33 3 90 40 61 50
Fax: +33 3 90 40 61 55

News Articles [1213 Associated News Articles listed on BioPortfolio]

Domain Therapeutics receives $125m to assign its intellectual property

Domain Therapeutics to receive up to $125 million for assignment of its intellectual property covering the Foliglurax mGluR4 PAM series discovered by a French biotech

Domain licenses GPCR technology to Bristol-Myers Squibb

Bristol-Myers Squibb Co. licensed nonexclusive rights to Domain Therapeutics SA's bioSens-All platform.

Domain Therapeutics Grants Bristol-Myers Squibb Non-Exclusive License for G protein-Coupled Receptor bioSens-All™ Technology

Technology provides access to new generation of sensitive biosensors to enhance drug discovery. Domain Therapeutics, a France- and Quebec-based biopharmaceutical company that specializes in the resear...

Hydrogen-mediated magnetic domain formation and domain wall motion in Co30Pd70 alloy films

Real-time observation of flexible domain movements in CRISPR-Cas9

The CRISPR-associated protein Cas9 is widely used for genome editing because it cleaves target DNA through the assistance of a single-guide RNA (sgRNA). Structural studies have revealed the multi-doma...

Transmembrane redox control and proteolysis of PdeC, a novel type of c-di-GMP phosphodiesterase

The nucleotide second messenger c-di-GMP nearly ubiquitously promotes bacterial biofilm formation, with enzymes that synthesize and degrade c-di-GMP being controlled by diverse N-terminal sensor domai...

Revealed: The Army and Air Force Are Working on New War Plans for the Future

The U.S. Army and Air Force are teaming up with a series of new Wargames to develop new cross-domain warfare doctrine. The Army and the Air Force are launching a new, collaborative war-gaming operati...

PTRN-1/CAMSAP promotes CYK-1/formin-dependent actin polymerization during endocytic recycling

Cargo sorting and membrane carrier initiation in recycling endosomes require appropriately coordinated actin dynamics. However, the mechanism underlying the regulation of actin organization during rec...

PubMed Articles [1273 Associated PubMed Articles listed on BioPortfolio]

Engineering Bifunctional Enzymes Capable of Adenylating and Selectively Methylating the Side Chain or Core of Amino Acids.

Nonribosomal peptides (NRPs) are known sources of therapeutics. Some nonribosomal peptide synthetase assembly lines contain unique functional interrupted adenylation (A) domains, where nature has comb...

Protein engineering allows for mild affinity-based elution of therapeutic antibodies.

Presented here is an engineered protein domain, based on Protein A, that displays a calcium-dependent binding to antibodies. This protein, Z, is shown to efficiently function as an affinity ligand for...

Autophagic Regulation of p62 is Critical for Cancer Therapy.

Sequestosome1 (p62/SQSTM 1) is a multidomain protein that interacts with the autophagy machinery as a key adaptor of target cargo. It interacts with phagophores through the LC3-interacting (LIR) domai...

RNA Therapeutics (Almost) Comes of Age: Targeting, Delivery and Endosomal Escape.

The regulation mechanisms of AhR by molecular chaperone complex.

The AhR, so called the dioxin receptor, is a member of the nuclear receptor superfamily. The ligand-free AhR forms a cytosolic protein complex with the molecular chaperone HSP90, co-chaperone p23, and...

Clinical Trials [347 Associated Clinical Trials listed on BioPortfolio]

Ocular Imaging With Spectral Domain Optical Coherence Tomography

The purpose of this study is to analyze macular retinal thickness and macular volume using the spectral domain - optical coherence tomography (SD-OCT) in normal eyes and in eyes with vario...

Pilot Study To Evaluate Optical Frequency Domain Imaging For Diagnosis Of Central Airway Disease

To evaluate the potential of a new imaging device, termed Optical Frequency Domain Imaging (OFDI), in the early diagnosing of pulmonary malignancies in the central airways.

Impact of Ibis on Patients With Advanced COPD

The purpose of this research is to determine if Ibis™, a digital therapeutics solution developed by Senscio Systems, reduces the emergency room visits and hospitalizations of patients wi...

HDL Acute Lipid Optimization in Homozygous Familial Hypercholesterolemia

Assess the effect on coronary atheroma of serial infusions of autologous selectively delipidated HDL/preβ enriched plasma following use of HDL Therapeutics PDS-2™ System

Protocol of Multi-domain Attention Training

This study sought to investigate the changes in attention in older adults with mild cognitive impairment after Multi-domain Attention Training .

Companies [1426 Associated Companies listed on BioPortfolio]

Domain Therapeutics

Domain Therapeutics is a biopharmaceutical company located in Strasbourg, France, dedicated to the discovery and early development of small molecules targeting G-coupled Protein Receptors (GPCRs), o... was founded in 2009 with a simple goal - to help domain investors evolve from a singular dependence on domain parking to a more diversified array of value creation strategies that unlock the ...

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Whether you are looking for the perfect domain name for a new web site or simply trying to increase traffic to your existing web site, you will find it at BuyDomains. With our exclusive selection of o...

NameMedia, Inc.BuyDomains Division

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Domain devotes considerable attention and resources to the earliest stage companies that we incorporate ourselves and initially support within our offices. In these instances, Domain forms a company ...

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