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Domain Therapeutics Company Profile

04:36 EDT 20th September 2018 | BioPortfolio

Domain Therapeutics is a biopharmaceutical company located in Strasbourg, France, dedicated to the discovery and early development of small molecules targeting G-coupled Protein Receptors (GPCRs), one of the best classes of drug targets.

Domain Therapeutics is using its innovative and proprietary technology platform DTect-All™ to identify orthosteric and allosteric ligands of GPCRs, including the so called Silent Allosteric Modulators (SAMs) that represent a unique source of compounds that cannot be discovered by standard technologies. DTect-All™ is able to address difficult GPCRs such as orphan and peptidic GPCRs.

The company’s pipeline is composed of new chemical entities ranging from hits to optimized leads targeting hot GPCRs for leading indications such as Parkinson’s disease, schizophrenia, Alzheimer’s disease and diabetes.

Location

BIOPARC
Boulevard Sébastien Brant
ILLKIRCH-STRASBOURG
67400
FR

Contact

Phone: +33 3 90 40 61 50
Fax: +33 3 90 40 61 55
Email: contact@domaintherapeutics.com


News Articles [827 Associated News Articles listed on BioPortfolio]

Domain Therapeutics receives $125m to assign its intellectual property

Domain Therapeutics to receive up to $125 million for assignment of its intellectual property covering the Foliglurax mGluR4 PAM series discovered by a French biotech

Domain licenses GPCR technology to Bristol-Myers Squibb

Bristol-Myers Squibb Co. licensed nonexclusive rights to Domain Therapeutics SA's bioSens-All platform.

Domain Therapeutics Grants Bristol-Myers Squibb Non-Exclusive License for G protein-Coupled Receptor bioSens-All™ Technology

Technology provides access to new generation of sensitive biosensors to enhance drug discovery. Domain Therapeutics, a France- and Quebec-based biopharmaceutical company that specializes in the resear...

Hydrogen-mediated magnetic domain formation and domain wall motion in Co30Pd70 alloy films

The ZZ domain of p300 mediates specificity of the adjacent HAT domain for histone H3

Real-time observation of flexible domain movements in CRISPR-Cas9

The CRISPR-associated protein Cas9 is widely used for genome editing because it cleaves target DNA through the assistance of a single-guide RNA (sgRNA). Structural studies have revealed the multi-doma...

Transmembrane redox control and proteolysis of PdeC, a novel type of c-di-GMP phosphodiesterase

The nucleotide second messenger c-di-GMP nearly ubiquitously promotes bacterial biofilm formation, with enzymes that synthesize and degrade c-di-GMP being controlled by diverse N-terminal sensor domai...

California.com Domain Name Acquired by One Planet Ops

WALNUT CREEK, Calif., Aug. 22, 2018 /PRNewswire/ -- One Planet Ops, Inc. announced today that it has acquired the domain name California.com, and intends to Read more...

PubMed Articles [1305 Associated PubMed Articles listed on BioPortfolio]

Protein engineering allows for mild affinity-based elution of therapeutic antibodies.

Presented here is an engineered protein domain, based on Protein A, that displays a calcium-dependent binding to antibodies. This protein, Z, is shown to efficiently function as an affinity ligand for...

Investigation of the interaction of allergens of Glycine max with IgE-antibody for designing of peptidomimetics based anti-allergen.

Allergen induced IgE dependent type I hypersensitivity is the main cause of the allergy, which would be a burden on medical setup in coming years. Allergens of Glycine max have been isolated, and thei...

Autophagic Regulation of p62 is Critical for Cancer Therapy.

Sequestosome1 (p62/SQSTM 1) is a multidomain protein that interacts with the autophagy machinery as a key adaptor of target cargo. It interacts with phagophores through the LC3-interacting (LIR) domai...

RNA Therapeutics (Almost) Comes of Age: Targeting, Delivery and Endosomal Escape.

Thiourea-Based Inhibitors of the B-Cell Lymphoma 6 (BCL6) BTB Domain via NMR-Based Fragment Screening and Computer-Aided Drug Design.

Protein-protein interactions (PPI) between the transcriptional repressor B-cell lymphoma 6 (BCL6) BTB domain (BCL6BTB) and its co-repressors have emerged as a promising target for anti-cancer therapeu...

Clinical Trials [369 Associated Clinical Trials listed on BioPortfolio]

Ocular Imaging With Spectral Domain Optical Coherence Tomography

The purpose of this study is to analyze macular retinal thickness and macular volume using the spectral domain - optical coherence tomography (SD-OCT) in normal eyes and in eyes with vario...

Pilot Study To Evaluate Optical Frequency Domain Imaging For Diagnosis Of Central Airway Disease

To evaluate the potential of a new imaging device, termed Optical Frequency Domain Imaging (OFDI), in the early diagnosing of pulmonary malignancies in the central airways.

Impact of Ibis on Patients With Advanced COPD

The purpose of this research is to determine if Ibis™, a digital therapeutics solution developed by Senscio Systems, reduces the emergency room visits and hospitalizations of patients wi...

HDL Acute Lipid Optimization in Homozygous Familial Hypercholesterolemia

Assess the effect on coronary atheroma of serial infusions of autologous selectively delipidated HDL/preβ enriched plasma following use of HDL Therapeutics PDS-2™ System

Protocol of Multi-domain Attention Training

This study sought to investigate the changes in attention in older adults with mild cognitive impairment after Multi-domain Attention Training .

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More Information about "Domain Therapeutics" on BioPortfolio

We have published hundreds of Domain Therapeutics news stories on BioPortfolio along with dozens of Domain Therapeutics Clinical Trials and PubMed Articles about Domain Therapeutics for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Domain Therapeutics Companies in our database. You can also find out about relevant Domain Therapeutics Drugs and Medications on this site too.

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