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Checkpoint Systems Company Profile

16:30 EDT 24th June 2018 | BioPortfolio


News Articles [729 Associated News Articles listed on BioPortfolio]

From checkpoint to checkpoint: DNA damage ATR/Chk1 checkpoint signalling elicits PD-L1 immune checkpoint activation

Infographic: What Are Checkpoint Inhibitors and How Do They Fight Cancer?

Everything you need to know about what checkpoint inhibitors are and why they have caused a wave of hype for cancer immunotherapies.  Since the approval of the first PD-1 checkpoint inhibitor, Keytru...

Are PD-1 and PD-L1 Checkpoint Inhibitors As Good As We Thought?

Checkpoint inhibitors, especially those targeting PD-1 and PD-L1, are exploding in popularity. But how much of it is hype? The pipelines of biotech and pharma are filling up with combination therapie...

Yet Another Checkpoint Inhibitor Goes to Trial with Bavarian Nordic’s Cancer Vaccine

Bavarian Nordic and AstraZeneca collaborate on a treatment that uses a cancer vaccine along with a checkpoint inhibitor to treat colorectal and pancreatic cancer. Notably, this is the third checkpoint...

Can we predict early treatment discontinuation on immune checkpoint therapy?

One of the many challenges we have seen with cancer immunotherapy and immune checkpoint blockade in particular is the thorny…

Boosting the Potential of Checkpoint Inhibitors

John SchieszerSep 27, 2017Researchers recently discovered that beta blockers, commonly used to treat hypertension, may be used to improve the efficacy of anti-PD-1 checkpoint blockade in cancer patien...

BI snaps up OSE’s novel checkpoint inhibitor

Boehringer Ingelheim and OSE Immunotherapeutics have joined forced to develop OSE-172, a novel checkpoint inhibitor antibody targeting myeloid lineage cells for the treatment of advanced solid tumours...

Potential Role for Vaccines, Checkpoint Inhibitors in Chemoprevention of Lynch Syndrome

Researchers from MD Anderson say their study results "open the field of immunoprevention in LS to checkpoint inhibitors as an immune interception strategy."

PubMed Articles [1187 Associated PubMed Articles listed on BioPortfolio]

Toward innovative combinational immunotherapy: A systems biology perspective.

The treatment of non-small-cell lung cancer (NSCLC) has advanced significantly in the last decades. Especially immune checkpoint inhibitors have shown inconceivable effect on enhancing host anti-tumor...

Orchestration of DNA Damage Checkpoint Dynamics across the Human Cell Cycle.

Although molecular mechanisms that prompt cell-cycle arrest in response to DNA damage have been elucidated, the systems-level properties of DNA damage checkpoints are not understood. Here, using time-...

Uveal Effusion After Immune Checkpoint Inhibitor Therapy.

Immune checkpoint inhibitors, including antiprogrammed cell death protein-1 (anti-PD-1) and antiprogrammed cell death ligand-1 (anti-PD-L1) monoclonal antibodies, have recently been introduced as a pr...

Rheumatology. Checkpoint-induced autoimmunity - birth of a new disease.

Tumor cells express checkpoint proteins in order to prevent an immune reaction by T-cells. Checkpoint inhibitors are successfully used in oncology to unleash a cytotoxic immune response. Unfortunately...

Defining the Most Appropriate Primary End Point in Phase 2 Trials of Immune Checkpoint Inhibitors for Advanced Solid Cancers: A Systematic Review and Meta-analysis.

Checkpoint inhibitors have a unique mechanism of action that differs from chemotherapy or targeted therapies. The validity of objective response rate (ORR) as a surrogate for progression-free survival...

Clinical Trials [1140 Associated Clinical Trials listed on BioPortfolio]

Immune Checkpoint Inhibitors and Pre-existing Autoimmune Diseases

The tolerance of immune checkpoint inhibitors is unknown in patients with pre-existing autoimmune conditions. This retrospective nation-wide study will assess their tolerance in patients w...

Perioperative Chemo and Pembrolizumab in Gastric Cancer

The purpose of this study is to determine the effectiveness of combining immune checkpoint blockade therapy with standard chemotherapy. People who usually have this are treated with 3 cycl...

Vorolanib (X-82) Combined With Checkpoint Inhibitors in Patients With Solid Tumors

The investigators hypothesize that vorolanib in combination with checkpoint inhibitors (pembrolizumab for gastric/gastroesophageal (GE) junction cancers and nivolumab for hepatocellular ca...

Immune CHeckpoint Inhibitors Monitoring of Adverse Drug ReAction

Immune checkpoint inhibitors (ICIs) might have high grade immune-related adverse events (irAEs) from rhumatologic, endocrinologic, cardiac or other system origin. This study investigates r...

Long-Term Quality of Life in Patients With Metastatic Melanoma Treated With Checkpoint Inhibitors

To identify and describe long-term quality of life (QOL) issues in patients with metastatic melanoma treated with checkpoint inhibitors who achieved cancer control for a minimum of 12 mont...

Companies [1369 Associated Companies listed on BioPortfolio]

Checkpoint Systems, Inc.

Checkpoint Systems is a global leader in merchandise availability solutions for the retail industry, encompassing loss prevention and merchandise visibility. Checkpoint provides e...

Checkpoint Systems

FLX Bio, Inc.

FLX475 is a best-in-class oral, small molecule antagonist of CCR4. CCR4 ligands are elevated in multiple tumor types when compared to normal tissue. In preclinical studies, FLX475...

Agenus, Inc.

Agenus is an immuno-oncology company developing a portfolio of checkpoint modulators (CPMs), heat shock protein vaccines and adjuvants. Agenus’ checkpoint modulator programs ...

Palleon Pharmaceuticals

Palleon Pharmaceuticals is the leading biotechnology company focused on developing Glycoimmune Checkpoint inhibitors to treat cancer. The company’s proprietary Convergence Pl...

More Information about "Checkpoint Systems" on BioPortfolio

We have published hundreds of Checkpoint Systems news stories on BioPortfolio along with dozens of Checkpoint Systems Clinical Trials and PubMed Articles about Checkpoint Systems for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Checkpoint Systems Companies in our database. You can also find out about relevant Checkpoint Systems Drugs and Medications on this site too.

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