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Checkpoint Systems Company Profile

11:25 EDT 18th September 2018 | BioPortfolio


News Articles [604 Associated News Articles listed on BioPortfolio]

From checkpoint to checkpoint: DNA damage ATR/Chk1 checkpoint signalling elicits PD-L1 immune checkpoint activation

Review discusses complexity of immune-suppressive mechanisms in tumor milieu of cancers

Cancers control immune systems and evade immune detection using mediators consisting of immune checkpoint molecules and cellular systems associated with immune suppression.

Are PD-1 and PD-L1 Checkpoint Inhibitors As Good As We Thought?

Checkpoint inhibitors, especially those targeting PD-1 and PD-L1, are exploding in popularity. But how much of it is hype? The pipelines of biotech and pharma are filling up with combination therapie...

Can we predict early treatment discontinuation on immune checkpoint therapy?

One of the many challenges we have seen with cancer immunotherapy and immune checkpoint blockade in particular is the thorny…

Boosting the Potential of Checkpoint Inhibitors

John SchieszerSep 27, 2017Researchers recently discovered that beta blockers, commonly used to treat hypertension, may be used to improve the efficacy of anti-PD-1 checkpoint blockade in cancer patien...

eFFECTOR Initiates Dosing of eFT508 (tomivosertib) in a Phase 2 Add-on (CPI-A) Trial in Combination with Checkpoint Inhibitors to Treat Patients with Insufficient Response to Checkpoint Inhibitors Alone

SAN DIEGO, July 27, 2018 (GLOBE NEWSWIRE) -- eFFECTOR Therapeutics, Inc., a leader in the development of selective translation regulators (STRs) for the treatment of cancer, today announced that it...

Have You Checked Checkpoint Therapeutics Yet?

Shares of Checkpoint Therapeutics Inc. (CKPT), a majority controlled subsidiary of Fortress Biotech Inc. (FBIO), are well off their highs recorded last September, and trade around $3.

Melanoma Biomarkers Predict Checkpoint Blocker Response

The outlook for patients with advanced melanoma has dramatically improved in recent years because of drugs known as immune checkpoint...

PubMed Articles [1232 Associated PubMed Articles listed on BioPortfolio]

Toward innovative combinational immunotherapy: A systems biology perspective.

The treatment of non-small-cell lung cancer (NSCLC) has advanced significantly in the last decades. Especially immune checkpoint inhibitors have shown inconceivable effect on enhancing host anti-tumor...

Implications of alternative routes to APC/C inhibition by the mitotic checkpoint complex.

The mitotic checkpoint (also called spindle assembly checkpoint) is a signaling pathway that ensures faithful chromosome segregation. Mitotic checkpoint proteins inhibit the anaphase-promoting complex...

Uveal Effusion After Immune Checkpoint Inhibitor Therapy.

Immune checkpoint inhibitors, including antiprogrammed cell death protein-1 (anti-PD-1) and antiprogrammed cell death ligand-1 (anti-PD-L1) monoclonal antibodies, have recently been introduced as a pr...

Defining the Most Appropriate Primary End Point in Phase 2 Trials of Immune Checkpoint Inhibitors for Advanced Solid Cancers: A Systematic Review and Meta-analysis.

Checkpoint inhibitors have a unique mechanism of action that differs from chemotherapy or targeted therapies. The validity of objective response rate (ORR) as a surrogate for progression-free survival...

Use of immune checkpoint inhibitors prolonged overall survival in a Japanese population of advanced malignant melanoma patients: Retrospective single institutional study.

Although recent clinical trials have revealed that immune checkpoint inhibitors significantly improved the overall survival (OS) of patients with advanced melanoma, these previous studies comprised ma...

Clinical Trials [1224 Associated Clinical Trials listed on BioPortfolio]

Immune Checkpoint Inhibitors and Pre-existing Autoimmune Diseases

The tolerance of immune checkpoint inhibitors is unknown in patients with pre-existing autoimmune conditions. This retrospective nation-wide study will assess their tolerance in patients w...

Perioperative Chemo and Pembrolizumab in Gastric Cancer

The purpose of this study is to determine the effectiveness of combining immune checkpoint blockade therapy with standard chemotherapy. People who usually have this are treated with 3 cycl...

Resistance to Immunotherapy in Gastric Cancer

This project seeks to analyze and define the mechanism (s) involved in the resistance to checkpoint therapy in metastatic GC patients. The investigators propose the use of a Next-Generatio...

Vorolanib (X-82) Combined With Checkpoint Inhibitors in Patients With Solid Tumors

The investigators hypothesize that vorolanib in combination with checkpoint inhibitors (pembrolizumab for gastric/gastroesophageal (GE) junction cancers and nivolumab for hepatocellular ca...

Immune CHeckpoint Inhibitors Monitoring of Adverse Drug ReAction

Immune checkpoint inhibitors (ICIs) might have high grade immune-related adverse events (irAEs) from rhumatologic, endocrinologic, cardiac or other system origin. This study investigates r...

Companies [1377 Associated Companies listed on BioPortfolio]

Checkpoint Systems, Inc.

Checkpoint Systems is a global leader in merchandise availability solutions for the retail industry, encompassing loss prevention and merchandise visibility. Checkpoint provides e...

Checkpoint Systems

FLX Bio, Inc.

FLX475 is a best-in-class oral, small molecule antagonist of CCR4. CCR4 ligands are elevated in multiple tumor types when compared to normal tissue. In preclinical studies, FLX475...

Agenus, Inc.

Agenus is an immuno-oncology company developing a portfolio of checkpoint modulators (CPMs), heat shock protein vaccines and adjuvants. Agenus’ checkpoint modulator programs ...

Palleon Pharmaceuticals

Palleon Pharmaceuticals is the leading biotechnology company focused on developing Glycoimmune Checkpoint inhibitors to treat cancer. The company’s proprietary Convergence Pl...

More Information about "Checkpoint Systems" on BioPortfolio

We have published hundreds of Checkpoint Systems news stories on BioPortfolio along with dozens of Checkpoint Systems Clinical Trials and PubMed Articles about Checkpoint Systems for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Checkpoint Systems Companies in our database. You can also find out about relevant Checkpoint Systems Drugs and Medications on this site too.

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