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Checkpoint Systems Company Profile

23:34 EST 14th December 2018 | BioPortfolio


News Articles [718 Associated News Articles listed on BioPortfolio]

Review discusses complexity of immune-suppressive mechanisms in tumor milieu of cancers

Cancers control immune systems and evade immune detection using mediators consisting of immune checkpoint molecules and cellular systems associated with immune suppression.

Can CytomX’s Probody checkpoint beat the competition?

We have increasingly seen how oncologists like the efficacy associated with the immune checkpoint combination of ipilimumab plus nivolumab, but…

Checkpoint Inhibitors Driving the Immunotherapy Market

The multibillion-dollar immunotherapy market is expected to experience further growth on advancements in checkpoint inhibitor biotechnology. The post Checkpoint Inhibitors Driving the Immunotherapy Ma...

Boosting the Potential of Checkpoint Inhibitors

John SchieszerSep 27, 2017Researchers recently discovered that beta blockers, commonly used to treat hypertension, may be used to improve the efficacy of anti-PD-1 checkpoint blockade in cancer patien...

eFFECTOR Initiates Dosing of eFT508 (tomivosertib) in a Phase 2 Add-on (CPI-A) Trial in Combination with Checkpoint Inhibitors to Treat Patients with Insufficient Response to Checkpoint Inhibitors Alone

SAN DIEGO, July 27, 2018 (GLOBE NEWSWIRE) -- eFFECTOR Therapeutics, Inc., a leader in the development of selective translation regulators (STRs) for the treatment of cancer, today announced that it...

Melanoma Biomarkers Predict Checkpoint Blocker Response

The outlook for patients with advanced melanoma has dramatically improved in recent years because of drugs known as immune checkpoint...

Have You Checked Checkpoint Therapeutics Yet?

Shares of Checkpoint Therapeutics Inc. (CKPT), a majority controlled subsidiary of Fortress Biotech Inc. (FBIO), are well off their highs recorded last September, and trade around $3.

Enthusiasm for checkpoint inhibitor combination trials shows no sign of abating

Combinations involving checkpoint therapies are starting to be used as the standard of care in certain metastatic cancer types, such...Read More... The post Enthusiasm for checkpoint inhibitor combina...

PubMed Articles [1217 Associated PubMed Articles listed on BioPortfolio]

Toward innovative combinational immunotherapy: A systems biology perspective.

The treatment of non-small-cell lung cancer (NSCLC) has advanced significantly in the last decades. Especially immune checkpoint inhibitors have shown inconceivable effect on enhancing host anti-tumor...

Implications of alternative routes to APC/C inhibition by the mitotic checkpoint complex.

The mitotic checkpoint (also called spindle assembly checkpoint) is a signaling pathway that ensures faithful chromosome segregation. Mitotic checkpoint proteins inhibit the anaphase-promoting complex...

Checkpoint Inhibitors Hodgkin Lymphoma and Non-Hodgkin Lymphoma.

The ligation of PD-1 with PD-L1 activates a critical immune checkpoint leading to T cell dysfunction, exhaustion, and tolerance. Anti-PD-1 or anti-PD-L1 monoclonal antibodies can reverse the immune ch...

Use of immune checkpoint inhibitors prolonged overall survival in a Japanese population of advanced malignant melanoma patients: Retrospective single institutional study.

Although recent clinical trials have revealed that immune checkpoint inhibitors significantly improved the overall survival (OS) of patients with advanced melanoma, these previous studies comprised ma...

The challenges of checkpoint inhibition in the treatment of multiple myeloma.

Despite significant improvements in the overall survival of patients with multiple myeloma (MM) over the past 15 years, the disease remains incurable. Treatment options are limited for patients who ...

Clinical Trials [1319 Associated Clinical Trials listed on BioPortfolio]

Immune Checkpoint Inhibitors and Pre-existing Autoimmune Diseases

The tolerance of immune checkpoint inhibitors is unknown in patients with pre-existing autoimmune conditions. This retrospective nation-wide study will assess their tolerance in patients w...

Perioperative Chemo and Pembrolizumab in Gastric Cancer

The purpose of this study is to determine the effectiveness of combining immune checkpoint blockade therapy with standard chemotherapy. People who usually have this are treated with 3 cycl...

Resistance to Immunotherapy in Gastric Cancer

This project seeks to analyze and define the mechanism (s) involved in the resistance to checkpoint therapy in metastatic GC patients. The investigators propose the use of a Next-Generatio...

Vorolanib (X-82) Combined With Checkpoint Inhibitors in Patients With Solid Tumors

The investigators hypothesize that vorolanib in combination with checkpoint inhibitors (pembrolizumab for gastric/gastroesophageal (GE) junction cancers and nivolumab for hepatocellular ca...

Immune CHeckpoint Inhibitors Monitoring of Adverse Drug ReAction

Immune checkpoint inhibitors (ICIs) might have high grade immune-related adverse events (irAEs) from rhumatologic, endocrinologic, cardiac or other system origin. This study investigates r...

Companies [1387 Associated Companies listed on BioPortfolio]

Checkpoint Systems, Inc.

Checkpoint Systems is a global leader in merchandise availability solutions for the retail industry, encompassing loss prevention and merchandise visibility. Checkpoint provides e...

Checkpoint Surgical, Inc.

Checkpoint Surgical is a privately held, Cleveland, Ohio based medical device company committed to providing surgeons with user-friendly, cost-effective devices to protect and rep...

Checkpoint Systems

FLX Bio, Inc.

FLX475 is a best-in-class oral, small molecule antagonist of CCR4. CCR4 ligands are elevated in multiple tumor types when compared to normal tissue. In preclinical studies, FLX475...

Agenus, Inc.

Agenus is an immuno-oncology company developing a portfolio of checkpoint modulators (CPMs), heat shock protein vaccines and adjuvants. Agenus’ checkpoint modulator programs ...

More Information about "Checkpoint Systems" on BioPortfolio

We have published hundreds of Checkpoint Systems news stories on BioPortfolio along with dozens of Checkpoint Systems Clinical Trials and PubMed Articles about Checkpoint Systems for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Checkpoint Systems Companies in our database. You can also find out about relevant Checkpoint Systems Drugs and Medications on this site too.

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