Bionomics Limited Company Profile

08:59 EST 12th December 2018 | BioPortfolio

Bionomics (ASX: BNO) is an Australian based international biotechnology company which discovers and develops innovative therapeutics for cancer and diseases of the central nervous system. Bionomics has small molecule and antibody product development programs in the areas of cancer, anxiety, and memory loss. Its oncology approach includes cancer stem cell therapeutics as well as vascular disruption in solid tumours.
BNC105, which is undergoing Phase II clinical development in a range of solid tumour types, is based upon the identification of a novel compound that potently and selectively restricts blood flow within tumours. BNC105 offers blockbuster potential if successfully developed. A clinical program is also underway for the treatment of anxiety disorders and depression based on IW-2143(BNC210), a novel compound which stimulates neurite outgrowth. IW-2143 is partnered with Ironwood Pharmaceuticals.

Bionomics' discovery and development activities are driven by its four proprietary technology platforms: Angene®, a drug discovery platform which incorporates a variety of genomics tools to identify and validate novel angiogenesis targets (involved in the formation of new blood vessels); MultiCore®, a diversity orientated chemistry platform for the discovery of small molecule drugs; ionX® , a set of novel technologies for the identification of drugs targeting ion channels for diseases of the central nervous system; and CSC Rx Discovery™, which identifies antibody and small molecule therapeutics that inhibit the growth of cancer stem cells. These platforms drive Bionomics’ pipeline and underpin its established business strategy of securing partners for its key compounds.


Bionomics has a portfolio of drug candidates with potentially significant end-user markets with unmet clinical needs. Bionomics' pipeline includes BNC105, a "best in class" vascular disrupting agent for the treatment of solid tumours which is currently in Phase II clinical trials; BNC210, under development for the treatment of anxiety disorders by Bionomics' partner Ironwood Pharmaceuticals; and Kv1.3 blockers for the treatment of Multiple Sclerosis and other autoimmune conditions in partnership with Merck Serono. The latest addition to the pipeline is the Alpha 7 program which targets conditions where memory is impaired, including Alzheimer's Disease.


31 Dalgleish Street


Phone: +618 8354 6100
Fax: +618 8354 6199

News Articles [49 Associated News Articles listed on BioPortfolio]

Bionomics Announces that BNC210 Doesn’t Treat PTSD Symptoms

Yesterday, top-line data from Bionomics Limited revealed details of the biopharmaceutical company’s Phase II clinical trial of BNC210 in regards to patients with post traumatic stress disorder.

Deborah Rathjen explains why these are exciting times for Bionomics

In this episode of PharmaTelevision News Review, Fintan Walton talks to Dr Deborah Rathjen, CEO and MD of Bionomics Ltd.

Bionomics (BNO) - RESTORE trial completed, data this quarter

Edison Investment Research - Pharmaceutical & healthcare - Bionomics: Bionomics announced on 9 July 2018 that it had completed treatment in its 193-patient Phase II clinical study of BNC210 for post-t...

Bionomics (BNO) - PTSD programme on track for results in Q3

Edison Investment Research - Pharmaceutical & healthcare - Bionomics: The fiscal year 2018, which ended in June, was a major transition for Bionomics as it realigned itself to focus on disorders of th...

Bionomics Ltd: Deborah Rathjen shares their positive results from clinical trials in the areas of CNS and Oncology

In this episode of PharmaTelevision News Review, Fintan Walton talks to Deborah Rathjen, CEO and Managing Director of Bionomics Ltd.

Bionomics: Deborah Rathjen. Strategic partnering to ensure a well-balanced yet diverse pipeline in CNS and Oncology

In this episode of PharmaTelevision News Review, filmed at AusBio 2012 in Melbourne, Australia, Fintan Walton talks to Deborah Rathjen, CEO and MD at Bionomics

Bionomics, Deborah Rathjen: Developing a world-class portfolio of promising drug candidates

In this interview filmed at the 2013 AusBiotech Convention in Brisbane,Deborah Rathjen, CEO, Bionomics updates Fintan Walton on the company activities over the last 12 months, including their deal wit...

Deborah Rathjen, Bionomics

Deborah Rathjen, Bionomics

PubMed Articles [6 Associated PubMed Articles listed on BioPortfolio]

Bionomics and insecticide resistance of the arboviral vector Aedes albopictus in northern Lao PDR.

In the last four decades there has been a staggering increase in the geographical range of the arboviral vector Aedes albopictus (Skuse, 1894). This species is now found in every continent except Anta...

Vector bionomics and malaria transmission in an area of sympatry of An. arabiensis, An. coluzzii and An. gambiae.

Despite extensive genetic studies on their variability and differentiation, few is known about the specific and relative role of An. coluzzii, An. gambiae and An. arabiensis in areas of sympatry. Inde...

First Record of Aedes (Stegomyia) malayensis Colless (Diptera: Culicidae) in the Lao People's Democratic Republic, Based on Morphological Diagnosis and Molecular Analysis.

This is the first confirmed record of Aedes (Stegomyia) malayensis Colless from the Lao People's Democratic Republic. Its larvae were collected from rock pools and rock holes along the Nam Noy River i...

Bionomics of Anopheles subpictus (Diptera: Culicidae) in a Malaria Endemic Area, Southeastern Iran.

Anopheles subpictus Grassi is considered a secondary malaria vector in parts of Asia. The current study determined some ecological and bionomical characteristics of this species in southeastern Iran. ...

Diversity of Anopheles mosquitoes from four landscapes in the highest endemic region of malaria transmission in Brazil.

Malaria transmission in South America is overwhelmingly located in the Amazon region with limited cases outside that biome. A key factor in the mitigation of malaria transmission is the determination ...

Clinical Trials [0 Results]


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