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Viralytics Limited Company Profile

21:37 EST 27th February 2020 | BioPortfolio

Viralytics is an Australian biotechnology company, listed on the Australian Stock Exchange (ASX:VLA) and is quoted on the OTC market (VRACY). Focused on developing oncolytic virotherapy for the treatment of a wide range of cancers Viralytics' headquarters are in Sydney, Australia and research and operations are in Newcastle, Australia.

Oncolytic virotherapy makes use of the cancer destroying capabilities of a range of  benign viruses.  The potential of oncolytic virotherapy is the ability to treat cancers more effectively and with minimum side-effects.

Viralytics lead product CAVATAK™ has now entered the global phase II stage of clinical trial development with a Phase II trial, for Late Stage Melanoma - the CALM study - having been recently given the green light from the USA Food and Drug Administration (FDA) for proceeding in the USA. Viralytics has had it's successful Investigational New Drug (IND) application allowed, enabling this trial to be commenced in the USA during 2011.  The Phase II trial will investigate the effectiveness of intratumourally adminstered CAVATAK™ in the treatment of Late Stage Melanoma.

CAVATAK™, is part of the common cold family of viruses.  It is naturally occurring, genetically unaltered  Coxsackievirus A21.  As a cancer therapy CAVATAK™ has the potential to directly target, infect, multiply within and subsequently destroy a wide range of primary and metastasized cancer cells, while leaving healthy cells intact.   It works by seeking out and attaching itself to a protein that is highly expressed on cancer cells – (ICAM-1 protein). Once attached to this protein the virus is then able to insert itself into the cancer  cell, replicate and literally burst the cancer cell apart.  Thousands of progeny then spread and replicate this cycle of destruction. Once the cancer cells have been destroyed, tumour proteins are released into the blood which activates the body’s own immune system, identifying the tumour as foreign which enables the bodies own defences to come into play.

Viralytics' Phase I trials of CAVATAK™ have shown that the product is well tolerated in humans.

In addition to CAVATAK™, Viralytics is also investigating 4 other oncolytic viruses, Coxsackievirus A18,15,13 and  ECHOvirus1 (trademarked  EVATAK™) as cancer therapeutics.   These could be effective as oncolytic therapeutics in their own right or could potentially be used in combination with CAVATAK™.

The Company holds granted patents in all major markets including the USA and Europe.

Location

Suite 305, Level 3
66 Hunter Street
Sydney
NSW
2000
Australia

Contact

Phone: +61 (0)2 9988 4000
Fax: +61 (0)2 8068 6038
Email: Viralytics@Viralytics.com


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PubMed Articles [1 Associated PubMed Articles listed on BioPortfolio]

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Clinical Trials [0 Results]

None

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